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Pdcd4 programmed cell death 4 [ Mus musculus (house mouse) ]

Gene ID: 18569, updated on 23-Mar-2024

Summary

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Official Symbol
Pdcd4provided by MGI
Official Full Name
programmed cell death 4provided by MGI
Primary source
MGI:MGI:107490
See related
Ensembl:ENSMUSG00000024975 AllianceGenome:MGI:107490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ma3; Tis; D19Ucla1
Summary
Predicted to enable RNA binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; and positive regulation of inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; epithelium; oocyte; and thymus primordium. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 26.5), placenta adult (RPKM 14.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pdcd4 in Genome Data Viewer
Location:
19 D2; 19 48.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53880662..53926024)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53892231..53937592)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene, 30890 Neighboring gene STARR-seq mESC enhancer starr_46468 Neighboring gene predicted gene 16299 Neighboring gene STARR-seq mESC enhancer starr_46470 Neighboring gene STARR-positive B cell enhancer ABC_E8757 Neighboring gene STARR-positive B cell enhancer ABC_E11040 Neighboring gene predicted gene, 30990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53965483-53965684 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968181-53968334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968382-53968491 Neighboring gene STARR-positive B cell enhancer ABC_E622 Neighboring gene STARR-seq mESC enhancer starr_46471 Neighboring gene STARR-seq mESC enhancer starr_46472 Neighboring gene STARR-seq mESC enhancer starr_46473 Neighboring gene BBSome interacting protein 1 Neighboring gene Shoc2, leucine rich repeat scaffold protein Neighboring gene STARR-seq mESC enhancer starr_46474 Neighboring gene adrenergic receptor, alpha 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression. Li Y, et al. Mol Psychiatry, 2021 Jun. PMID 32203159, Free PMC Article
  2. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. Bai Y, et al. PLoS One, 2016. PMID 27454120, Free PMC Article
  3. Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells. Bai Y, et al. Cell Death Dis, 2016 Mar 31. PMID 27031966, Free PMC Article
  4. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. Wang L, et al. Inflamm Bowel Dis, 2016 May. PMID 26891257
  5. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair. Wang T, et al. Int J Mol Sci, 2015 Dec 23. PMID 26703592, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4.
    Title: MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4.
  2. [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
    Title: [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
  3. CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
    Title: CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
  4. Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders.
    Title: Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders.
  5. miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.
    Title: miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.
  6. PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-kappaB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
    Title: PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
  7. Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
    Title: Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
  8. LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.
    Title: LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.
  9. MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck.
    Title: MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck.
  10. MicroRNA421 attenuates macrophagemediated inflammation by inhibiting PDCD4 in vitro.
    Title: MicroRNA‑421 attenuates macrophage‑mediated inflammation by inhibiting PDCD4 in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of myofibroblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
programmed cell death protein 4
Names
protein MA-3
topoisomerase-inhibitor suppressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168491.1 → NP_001161963.1  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_001161963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Related
    ENSMUSP00000025931.7, ENSMUST00000025931.14
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  2. NM_001168492.1 → NP_001161964.1  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_001161964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612, BC055739
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Related
    ENSMUSP00000133135.2, ENSMUST00000165617.3
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  3. NM_011050.4 → NP_035180.2  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_035180.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612, AK134366
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Related
    ENSMUSP00000073975.6, ENSMUST00000074371.13
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    53880662..53926024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250768.2 → XP_030106628.1  programmed cell death protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  2. XM_036161459.1 → XP_036017352.1  programmed cell death protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  3. XM_006526762.5 → XP_006526825.1  programmed cell death protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006526825.1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  4. XM_036161461.1 → XP_036017354.1  programmed cell death protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  5. XM_030250769.1 → XP_030106629.1  programmed cell death protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  6. XM_036161460.1 → XP_036017353.1  programmed cell death protein 4 isoform X1

    UniProtKB/Swiss-Prot
    P97296, Q3T9A9, Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327 → 440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61823.1 GenPept UniProtKB/Swiss-Prot:Q61823

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