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Cdk16 cyclin dependent kinase 16 [ Mus musculus (house mouse) ]

Gene ID: 18555, updated on 11-Apr-2024

Summary

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Official Symbol
Cdk16provided by MGI
Official Full Name
cyclin dependent kinase 16provided by MGI
Primary source
MGI:MGI:97516
See related
Ensembl:ENSMUSG00000031065 AllianceGenome:MGI:97516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crk5; Pctk1; Pctaire1
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; secretion by cell; and spermatogenesis. Colocalizes with synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 104.3), adrenal adult (RPKM 90.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.3; X 16.18 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20554210..20566119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20687917..20699880)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5720 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:20264845-20265145 Neighboring gene predicted gene, 39499 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene predicted gene, 39500

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion. Shimizu K, et al. FEBS Lett, 2014 Aug 25. PMID 24931367
  2. The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation. Besset V, et al. Cell Growth Differ, 1999 Mar. PMID 10099831
  3. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Carrel L, et al. Hum Mol Genet, 1996 Mar. PMID 8852665
  4. CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. Zi Z, et al. PLoS Genet, 2015 Aug. PMID 26305884, Free PMC Article
  5. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. Okuda T, et al. Genomics, 1994 May 1. PMID 8088790

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.
    Title: CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.
  2. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis
    Title: Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion.
  3. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
    Title: Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
  4. Mice lacking CDK16 developed normally, but male mice were infertile. Spermatozoa isolated from their epididymis displayed thinning and elongation of the annulus region, adopted a bent shape, and showed impaired motility.
    Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.
  5. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development
    Title: Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development.
  6. findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity
    Title: Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 16
Names
PCTAIRE-motif protein kinase 1
cell division protein kinase 16
serine/threonine-protein kinase PCTAIRE-1
NP_001297385.1
NP_001398634.1
NP_001398636.1
NP_035179.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310456.2 → NP_001297385.1  cyclin-dependent kinase 16 isoform 2

    See identical proteins and their annotated locations for NP_001297385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 4 encode the same protein (isoform 2), which has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL807240
    Consensus CDS
    CCDS81103.1
    UniProtKB/TrEMBL
    Q3TM24, Q3UPI3, Q91WP4
    Related
    ENSMUSP00000111021.2, ENSMUST00000115364.8
    Conserved Domains (1) summary
    cd07873
    Location:127 → 423
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

  2. NM_001411705.1 → NP_001398634.1  cyclin-dependent kinase 16 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL807240
    UniProtKB/Swiss-Prot
    Q04735
    UniProtKB/TrEMBL
    Q543G3

  3. NM_001411707.1 → NP_001398636.1  cyclin-dependent kinase 16 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL807240
    UniProtKB/TrEMBL
    Q3TM24

  4. NM_011049.6 → NP_035179.1  cyclin-dependent kinase 16 isoform 1

    See identical proteins and their annotated locations for NP_035179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL807240
    Consensus CDS
    CCDS30045.1
    UniProtKB/Swiss-Prot
    Q04735
    UniProtKB/TrEMBL
    Q3UPI3, Q543G3, Q91WP4
    Related
    ENSMUSP00000033380.7, ENSMUST00000033380.7
    Conserved Domains (1) summary
    cd07873
    Location:162 → 458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20554210..20566119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04735.1 GenPept UniProtKB/Swiss-Prot:Q04735

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