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Pcna proliferating cell nuclear antigen [ Mus musculus (house mouse) ]

Gene ID: 18538, updated on 10-Dec-2024

Summary

Official Symbol
Pcnaprovided by MGI
Official Full Name
proliferating cell nuclear antigenprovided by MGI
Primary source
MGI:MGI:97503
See related
Ensembl:ENSMUSG00000027342 AllianceGenome:MGI:97503
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables enzyme binding activity. Involved in mitotic telomere maintenance via semi-conservative replication and replication fork processing. Acts upstream of or within base-excision repair, gap-filling; cellular response to xenobiotic stimulus; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus; nuclear lamina; and replication fork. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; genitourinary system; jaw; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in liver E14.5 (RPKM 270.8), liver E14 (RPKM 268.7) and 26 other tissues See more
Orthologs
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Genomic context

See Pcna in Genome Data Viewer
Location:
2 F2; 2 64.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132091206..132095100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132249286..132253180, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14051 Neighboring gene STARR-seq mESC enhancer starr_05736 Neighboring gene predicted gene, 29720 Neighboring gene STARR-positive B cell enhancer ABC_E10149 Neighboring gene transmembrane protein 230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132079079-132079188 Neighboring gene STARR-positive B cell enhancer ABC_E331 Neighboring gene expressed sequence AV099323 Neighboring gene predicted gene, 46766 Neighboring gene CDP-diacylglycerol synthase 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Function Evidence Code Pubs
enables DNA polymerase binding  
enables DNA polymerase binding  
enables DNA polymerase processivity factor activity  
enables DNA polymerase processivity factor activity  
enables MutLalpha complex binding  
enables MutLalpha complex binding  
enables chromatin binding  
enables chromatin binding  
enables damaged DNA binding  
enables damaged DNA binding  
enables dinucleotide insertion or deletion binding  
enables dinucleotide insertion or deletion binding  
enables enzyme binding PubMed 
enables enzyme binding  
enables histone acetyltransferase binding  
enables histone acetyltransferase binding  
enables identical protein binding  
enables identical protein binding  
enables nuclear estrogen receptor binding  
enables nuclear estrogen receptor binding  
enables protein binding PubMed 
enables protein-containing complex binding  
enables purine-specific mismatch base pair DNA N-glycosylase activity  
enables purine-specific mismatch base pair DNA N-glycosylase activity  
enables receptor tyrosine kinase binding  
enables receptor tyrosine kinase binding  
enables transcription factor binding PubMed 
Items 1 - 25 of 27
Items 1 - 25 of 31
Process Evidence Code Pubs
acts_upstream_of_or_within base-excision repair, gap-filling PubMed 
involved_in cellular response to UV  
involved_in cellular response to UV  
involved_in cellular response to hydrogen peroxide  
acts_upstream_of_or_within cellular response to xenobiotic stimulus PubMed 
involved_in epithelial cell differentiation  
involved_in estrous cycle  
involved_in heart development  
involved_in leading strand elongation  
involved_in liver regeneration  
involved_in mismatch repair  
involved_in mismatch repair  
involved_in mismatch repair  
involved_in mitotic telomere maintenance via semi-conservative replication PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of DNA repair  
involved_in positive regulation of DNA repair  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA-directed DNA polymerase activity  
involved_in positive regulation of deoxyribonuclease activity  
involved_in positive regulation of deoxyribonuclease activity  
involved_in replication fork processing PubMed 
involved_in response to L-glutamate  
involved_in response to cadmium ion  
involved_in response to dexamethasone  
involved_in response to estradiol  
involved_in response to lipid  
involved_in translesion synthesis  
involved_in translesion synthesis  
involved_in translesion synthesis  
Items 1 - 25 of 31
Items 1 - 20 of 22
Component Evidence Code Pubs
part_of PCNA complex  
part_of PCNA complex  
part_of PCNA complex  
part_of PCNA-p21 complex  
part_of PCNA-p21 complex  
located_in centrosome PubMed 
located_in chromatin  
located_in chromatin  
part_of cyclin-dependent protein kinase holoenzyme complex PubMed 
located_in intracellular anatomical structure PubMed 
located_in male germ cell nucleus PubMed 
located_in nuclear body  
located_in nuclear body  
located_in nuclear lamina PubMed 
located_in nuclear replication fork  
located_in nuclear replication fork  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus PubMed 
located_in replication fork PubMed 
located_in replication fork PubMed 
Items 1 - 20 of 22

General protein information

Preferred Names
proliferating cell nuclear antigen
Names
cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011045.2NP_035175.1  proliferating cell nuclear antigen

    See identical proteins and their annotated locations for NP_035175.1

    Status: PROVISIONAL

    Source sequence(s)
    AL807793
    Consensus CDS
    CCDS16771.1
    UniProtKB/Swiss-Prot
    P17918
    UniProtKB/TrEMBL
    Q542J9, Q91ZH2
    Related
    ENSMUSP00000028817.7, ENSMUST00000028817.7
    Conserved Domains (2) summary
    cd00577
    Location:4256
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    TIGR00590
    Location:1259
    pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132091206..132095100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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