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Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 18537, updated on 11-Apr-2024

Summary

Official Symbol
Pcmt1provided by MGI
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1provided by MGI
Primary source
MGI:MGI:97502
See related
Ensembl:ENSMUSG00000019795 AllianceGenome:MGI:97502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIMT
Summary
Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within protein methylation. Predicted to be located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Predicted to be active in cytoplasm. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 29.8), cerebellum adult (RPKM 17.1) and 27 other tissues See more
Orthologs
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Genomic context

Location:
10 A1; 10 2.26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7503608..7556922, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7627845..7681337, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene UL16 binding protein 1 Neighboring gene predicted gene, 46209 Neighboring gene STARR-positive B cell enhancer ABC_E3874 Neighboring gene STARR-seq mESC enhancer starr_25682 Neighboring gene predicted gene 16254 Neighboring gene low density lipoprotein receptor-related protein 11 Neighboring gene RIKEN cDNA A630066F11 gene Neighboring gene STARR-positive B cell enhancer ABC_E3875 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor Neighboring gene STARR-seq mESC enhancer starr_25689 Neighboring gene STARR-positive B cell enhancer ABC_E6817 Neighboring gene katanin p60 (ATPase-containing) subunit A1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in S-adenosylhomocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein-L-isoaspartate(D-aspartate) O-methyltransferase
Names
L-isoaspartyl protein carboxyl methyltransferase
protein L-isoaspartyl/D-aspartyl methyltransferase
protein carboxyl methyltransferase
protein-beta-aspartate methyltransferase
NP_001334157.2
NP_001345576.2
NP_001345578.1
NP_001345580.1
NP_001345581.1
NP_001345582.1
NP_001345583.1
NP_001345586.1
NP_001394120.1
NP_001394121.1
NP_001394122.1
NP_001394123.1
NP_001394124.1
NP_001394125.1
NP_001394126.1
NP_001394127.1
NP_001394128.1
NP_001394129.1
NP_001394130.1
NP_001394131.1
NP_001394132.1
NP_001394133.1
NP_001394134.1
NP_001394135.1
NP_001394138.1
NP_001394139.1
NP_001394140.1
NP_001394141.1
NP_001394142.1
NP_001394144.1
NP_001394145.1
NP_001394146.1
NP_001394147.1
NP_001394148.1
NP_001394149.1
NP_001394150.1
NP_001394156.1
NP_001394157.1
NP_001394158.1
NP_001394159.1
NP_001394160.1
NP_001394161.1
NP_001394162.1
NP_001394163.1
NP_001394164.1
NP_001394165.1
NP_001394166.1
NP_001394177.1
NP_001394178.1
NP_001394179.1
NP_001394180.1
NP_001394181.1
NP_001394182.1
NP_001394183.1
NP_001399029.1
NP_032812.3
XP_036011569.1
XP_036011570.1
XP_036011571.1
XP_036011572.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347228.5NP_001334157.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Consensus CDS
    CCDS83677.1
    Related
    ENSMUSP00000123866.3, ENSMUST00000162606.8
  2. NM_001358647.3NP_001345576.2  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156391
  3. NM_001358649.2NP_001345578.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156391
    UniProtKB/TrEMBL
    Q8BPI6
    Conserved Domains (1) summary
    pfam01135
    Location:10206
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  4. NM_001358651.2NP_001345580.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
    UniProtKB/TrEMBL
    Q8BPI6
    Conserved Domains (1) summary
    pfam01135
    Location:1190
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  5. NM_001358652.2NP_001345581.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
    UniProtKB/TrEMBL
    Q8BPI6
    Conserved Domains (1) summary
    pfam01135
    Location:1190
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  6. NM_001358653.2NP_001345582.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
    UniProtKB/TrEMBL
    Q8BPI6
    Conserved Domains (1) summary
    pfam01135
    Location:1190
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  7. NM_001358654.2NP_001345583.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  8. NM_001358657.2NP_001345586.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  9. NM_001407191.1NP_001394120.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
  10. NM_001407192.1NP_001394121.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC156391
  11. NM_001407193.1NP_001394122.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC156391
  12. NM_001407194.1NP_001394123.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC156391
  13. NM_001407195.1NP_001394124.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  14. NM_001407196.1NP_001394125.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  15. NM_001407197.1NP_001394126.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156391
  16. NM_001407198.1NP_001394127.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156391
  17. NM_001407199.1NP_001394128.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
  18. NM_001407200.1NP_001394129.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  19. NM_001407201.1NP_001394130.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  20. NM_001407202.1NP_001394131.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC156391
  21. NM_001407203.1NP_001394132.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC156391
  22. NM_001407204.1NP_001394133.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC156391
  23. NM_001407205.1NP_001394134.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC156391
  24. NM_001407206.1NP_001394135.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC156391
  25. NM_001407209.1NP_001394138.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC156391
  26. NM_001407210.1NP_001394139.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC156391
  27. NM_001407211.1NP_001394140.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC156391
  28. NM_001407212.1NP_001394141.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC156391
  29. NM_001407213.1NP_001394142.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC156391
  30. NM_001407215.1NP_001394144.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC156391
  31. NM_001407216.1NP_001394145.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  32. NM_001407217.1NP_001394146.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  33. NM_001407218.1NP_001394147.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156391
  34. NM_001407219.1NP_001394148.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156391
  35. NM_001407220.1NP_001394149.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC156391
  36. NM_001407221.1NP_001394150.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC156391
  37. NM_001407227.1NP_001394156.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC156391
  38. NM_001407228.1NP_001394157.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC156391
  39. NM_001407229.1NP_001394158.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  40. NM_001407230.1NP_001394159.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  41. NM_001407231.1NP_001394160.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  42. NM_001407232.1NP_001394161.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  43. NM_001407233.1NP_001394162.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156391
  44. NM_001407234.1NP_001394163.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
  45. NM_001407235.1NP_001394164.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156391
  46. NM_001407236.1NP_001394165.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC156391
  47. NM_001407237.1NP_001394166.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC156391
  48. NM_001407248.1NP_001394177.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC156391
  49. NM_001407249.1NP_001394178.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC156391
  50. NM_001407250.1NP_001394179.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC156391
  51. NM_001407251.1NP_001394180.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC156391
  52. NM_001407252.1NP_001394181.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC156391
  53. NM_001407253.1NP_001394182.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC156391
  54. NM_001407254.1NP_001394183.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC156391
  55. NM_001412100.1NP_001399029.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Related
    ENSMUSP00000123758.2, ENSMUST00000161428.8
  56. NM_008786.6NP_032812.3  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156391
    Consensus CDS
    CCDS23687.2
    UniProtKB/Swiss-Prot
    P23506, Q810R4
    UniProtKB/TrEMBL
    Q545L9
    Related
    ENSMUSP00000124932.3, ENSMUST00000159917.8

RNA

  1. NR_176302.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  2. NR_176303.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  3. NR_176304.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  4. NR_176305.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  5. NR_176306.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  6. NR_176307.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  7. NR_176308.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  8. NR_176309.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  9. NR_176310.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  10. NR_176311.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  11. NR_176312.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  12. NR_176313.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  13. NR_176314.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  14. NR_176315.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391
  15. NR_176316.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156391

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7503608..7556922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155676.1XP_036011569.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  2. XM_036155679.1XP_036011572.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  3. XM_036155677.1XP_036011570.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
  4. XM_036155678.1XP_036011571.1  protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform X5

    Conserved Domains (1) summary
    pfam01135
    Location:1153
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033219.1: Suppressed sequence

    Description
    NR_033219.1: This RefSeq was removed because the gene was discontinued.