U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pcm1 pericentriolar material 1 [ Mus musculus (house mouse) ]

Gene ID: 18536, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pcm1provided by MGI
Official Full Name
pericentriolar material 1provided by MGI
Primary source
MGI:MGI:1277958
See related
Ensembl:ENSMUSG00000031592 AllianceGenome:MGI:1277958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600002H09Rik; 9430077F19Rik; C030044G17Rik
Summary
Involved in microtubule anchoring and negative regulation of neurogenesis. Acts upstream of or within several processes, including microtubule anchoring at centrosome; nervous system development; and neuronal stem cell population maintenance. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 13.4), CNS E14 (RPKM 11.0) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pcm1 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41692521..41787125)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (41239484..41334088)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21287 Neighboring gene fibrinogen-like protein 1 Neighboring gene predicted gene 16348 Neighboring gene STARR-seq mESC enhancer starr_21288 Neighboring gene STARR-seq mESC enhancer starr_21289 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene STARR-seq mESC enhancer starr_21290 Neighboring gene STARR-positive B cell enhancer ABC_E1364 Neighboring gene FSHD region gene 1 Neighboring gene predicted gene, 50494

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Zoubovsky S, et al. Neurosci Res, 2015 Sep. PMID 25697395, Free PMC Article
  2. Molecular characterization of centriole assembly in ciliated epithelial cells. Vladar EK, et al. J Cell Biol, 2007 Jul 2. PMID 17606865, Free PMC Article
  3. Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies. Balczon R, et al. Cell Motil Cytoskeleton, 2002 Jul. PMID 12112146
  4. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Monroe TO, et al. Nat Commun, 2020 Nov 19. PMID 33214552, Free PMC Article
  5. MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. Zhang W, et al. Elife, 2016 Feb 17. PMID 26883496, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
    Title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
  2. MicroRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
    Title: MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.
  3. haploinsufficiency at the Pcm1 locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
    Title: Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1).
  4. deletion of Htt in ependymal cells led to PCM1 mislocalization, alteration of the cilia layer, and hydrocephalus
    Title: Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
  5. Pcm1 colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
    Title: Molecular characterization of centriole assembly in ciliated epithelial cells.
  6. results identify a novel role for PCM- 1 in cell cycle regulation, and indicate that PCM-1 must fulfill an essential function for cells to complete interphase
    Title: Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC170660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interkinetic nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule anchoring at centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex localization to centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
pericentriolar material 1 protein
Names
PCM-1
mPCM-1
pericentriolar material gene 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403817.1 → NP_001390746.1  pericentriolar material 1 protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    Related
    ENSMUSP00000147887.2, ENSMUST00000211247.2

  2. NM_001403819.1 → NP_001390748.1  pericentriolar material 1 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554

  3. NM_001403820.1 → NP_001390749.1  pericentriolar material 1 protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554

  4. NM_001403823.1 → NP_001390752.1  pericentriolar material 1 protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554

  5. NM_001403824.1 → NP_001390753.1  pericentriolar material 1 protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554

  6. NM_001403825.1 → NP_001390754.1  pericentriolar material 1 protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554

  7. NM_023662.4 → NP_076151.2  pericentriolar material 1 protein isoform 4

    See identical proteins and their annotated locations for NP_076151.2

    Status: VALIDATED

    Source sequence(s)
    AC144926, AC156554
    Consensus CDS
    CCDS22261.1
    UniProtKB/Swiss-Prot
    E9QLK2, O70287, Q3URH6, Q7TMS7, Q8C9V2, Q91Y27, Q91Y28, Q91Y51, Q923L0, Q9CRK8, Q9CT57, Q9R0L6
    UniProtKB/TrEMBL
    B2RSW8
    Related
    ENSMUSP00000039709.8, ENSMUST00000045218.9
    Conserved Domains (1) summary
    pfam15717
    Location:1369 → 1999
    PCM1_C; Pericentriolar material 1 C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41692521..41787125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153815.1 → XP_036009708.1  pericentriolar material 1 protein isoform X1

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1415 → 2045
    PCM1_C; Pericentriolar material 1 C-terminus

  2. XM_036153818.1 → XP_036009711.1  pericentriolar material 1 protein isoform X6

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1415 → 2000
    PCM1_C; Pericentriolar material 1 C-terminus

  3. XM_006509300.3 → XP_006509363.1  pericentriolar material 1 protein isoform X7

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1408 → 1993
    PCM1_C; Pericentriolar material 1 C-terminus

  4. XM_006509301.3 → XP_006509364.1  pericentriolar material 1 protein isoform X9

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (2) summary
    COG1196
    Location:229 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1353 → 1983
    PCM1_C; Pericentriolar material 1 C-terminus

  5. XM_036153819.1 → XP_036009712.1  pericentriolar material 1 protein isoform X8

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (2) summary
    COG1196
    Location:229 → 463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15717
    Location:1357 → 1987
    PCM1_C; Pericentriolar material 1 C-terminus

  6. XM_036153817.1 → XP_036009710.1  pericentriolar material 1 protein isoform X4

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1376 → 2006
    PCM1_C; Pericentriolar material 1 C-terminus

  7. XM_036153822.1 → XP_036009715.1  pericentriolar material 1 protein isoform X13

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1369 → 1954
    PCM1_C; Pericentriolar material 1 C-terminus

  8. XM_036153823.1 → XP_036009716.1  pericentriolar material 1 protein isoform X14

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1318 → 1948
    PCM1_C; Pericentriolar material 1 C-terminus

  9. XM_036153824.1 → XP_036009717.1  pericentriolar material 1 protein isoform X16

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1311 → 1941
    PCM1_C; Pericentriolar material 1 C-terminus

  10. XM_036153816.1 → XP_036009709.1  pericentriolar material 1 protein isoform X3

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1382 → 2012
    PCM1_C; Pericentriolar material 1 C-terminus

  11. XM_036153821.1 → XP_036009714.1  pericentriolar material 1 protein isoform X12

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1375 → 1960
    PCM1_C; Pericentriolar material 1 C-terminus

  12. XM_036153820.1 → XP_036009713.1  pericentriolar material 1 protein isoform X11

    UniProtKB/TrEMBL
    B2RSW8
    Conserved Domains (1) summary
    pfam15717
    Location:1343 → 1973
    PCM1_C; Pericentriolar material 1 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0L6.2 GenPept UniProtKB/Swiss-Prot:Q9R0L6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous