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Pcdh8 protocadherin 8 [ Mus musculus (house mouse) ]

Gene ID: 18530, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdh8provided by MGI
Official Full Name
protocadherin 8provided by MGI
Primary source
MGI:MGI:1306800
See related
Ensembl:ENSMUSG00000036422 AllianceGenome:MGI:1306800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Papc; 1700080P15Rik
Summary
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]
Expression
Biased expression in whole brain E14.5 (RPKM 19.8), CNS E18 (RPKM 18.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D3; 14 42.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (80004224..80008752, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79766772..79771312, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37268 Neighboring gene STARR-seq mESC enhancer starr_37269 Neighboring gene microRNA 759 Neighboring gene predicted gene, 51404 Neighboring gene predicted gene 9748 Neighboring gene predicted gene 10845 Neighboring gene predicted gene 6999 Neighboring gene ubiquitin specific peptidase 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice. Inoue Y, et al. J Comp Neurol, 2022 Aug. PMID 35368102
  2. delta-Protocadherins: unique structures and functions. Redies C, et al. Cell Mol Life Sci, 2005 Dec. PMID 16261259
  3. Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development. Yamamoto A, et al. Genesis, 2000 Jun. PMID 10890978
  4. MicroRNA-429 functions as a regulator of epithelial-mesenchymal transition by targeting Pcdh8 during murine embryo implantation. Li Z, et al. Hum Reprod, 2015 Mar. PMID 25609238
  5. Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development. Makarenkova H, et al. Biochim Biophys Acta, 2005 Jan 11. PMID 15627506

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice.
    Title: Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice.
  2. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin
    Title: PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion.
  3. miR-429 suppresses the expression of Pcdh8 mRNA and protein.
    Title: MicroRNA-429 functions as a regulator of epithelial-mesenchymal transition by targeting Pcdh8 during murine embryo implantation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protocadherin-8
Names
arcadlin
paraxial protocadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042726.4 → NP_001036191.1  protocadherin-8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151973
    Consensus CDS
    CCDS79349.1
    UniProtKB/Swiss-Prot
    Q7TSK3
    Related
    ENSMUSP00000141417.2, ENSMUST00000195355.2
    Conserved Domains (2) summary
    cd11304
    Location:501 → 605
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:31 → 109
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  2. NM_021543.5 → NP_067518.2  protocadherin-8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067518.2

    Status: VALIDATED

    Source sequence(s)
    AC151973
    Consensus CDS
    CCDS27303.1
    UniProtKB/Swiss-Prot
    Q05BD0, Q7TSK3, Q8C824, Q9JKP3
    Related
    ENSMUSP00000045333.6, ENSMUST00000039568.11
    Conserved Domains (2) summary
    cd11304
    Location:501 → 605
    Cadherin_repeat; Cadherin tandem repeat domain
    cl09101
    Location:31 → 109
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    80004224..80008752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSK3.1 GenPept UniProtKB/Swiss-Prot:Q7TSK3

Gene LinkOut

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