U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DUSP7 dual specificity phosphatase 7 [ Homo sapiens (human) ]

Gene ID: 1849, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DUSP7provided by HGNC
Official Full Name
dual specificity phosphatase 7provided by HGNC
Primary source
HGNC:HGNC:3073
See related
Ensembl:ENSG00000164086 MIM:602749; AllianceGenome:HGNC:3073
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MKPX; PYST2
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Ubiquitous expression in esophagus (RPKM 18.5), skin (RPKM 16.3) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3p21.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52048919..52056571, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52081823..52089474, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52082935..52090587, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52027370-52028102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52038485-52039365 Neighboring gene ribosomal protein L29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52049045-52049924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52052748-52053510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52053511-52054273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19925 Neighboring gene Sharpr-MPRA regulatory region 12856 Neighboring gene uncharacterized LOC105377088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52065550-52066066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52066067-52066581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52073992-52074561 Neighboring gene uncharacterized LOC124906238 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:52080336-52081535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52101953-52102546 Neighboring gene long intergenic non-protein coding RNA 696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52104737-52105238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52112399-52113318 Neighboring gene POC1 centriolar protein A Neighboring gene Sharpr-MPRA regulatory region 14635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19927 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52187832-52188809

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway. Bai H, et al. J Cell Mol Med, 2021 Oct. PMID 34435746, Free PMC Article
  2. Does the dual-specificity MAPK phosphatase Pyst2-L lead a monogamous relationship with the Erk2 protein? Orlev LN, et al. Immunol Lett, 2004 Mar 29. PMID 15081539
  3. cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. Levy-Nissenbaum O, et al. Methods Enzymol, 2003. PMID 14674243
  4. Characterization of the dual-specificity phosphatase PYST2 and its transcripts. Levy-Nissenbaum O, et al. Genes Chromosomes Cancer, 2004 Jan. PMID 14603440
  5. Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells. Levy-Nissenbaum O, et al. Oncogene, 2003 Oct 23. PMID 14576828

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
    Title: Transcription Factor FOSL1 Enhances Drug Resistance of Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
  2. DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway.
    Title: DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway.
  3. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
    Title: DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.
  4. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis.
    Title: mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.
  5. overexpressed in acute myelogenous leukemia
    Title: cDNA microarray analysis reveals an overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia.
  6. high levels of Pyst2-L detected in the active state of AML and ALL diseases and in other types of cancer reflect an altered MAPK signaling pathway in such malignant processes
    Title: Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp586F2224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
  
enables protein tyrosine/serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade TAS
Traceable Author Statement
more info
  
involved_in MAPK cascade TAS
Traceable Author Statement
more info
  
involved_in negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 7
Names
dual specificity protein phosphatase PYST2
NP_001938.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001947.4 → NP_001938.2  dual specificity protein phosphatase 7

    See identical proteins and their annotated locations for NP_001938.2

    Status: VALIDATED

    Source sequence(s)
    AC115284, AL110157, BC019107, CN429806, DN999200, X93921
    Consensus CDS
    CCDS33766.2
    UniProtKB/Swiss-Prot
    Q16829, Q2M3J7, Q8NFJ0
    Related
    ENSP00000417183.1, ENST00000495880.2
    Conserved Domains (2) summary
    cd01446
    Location:55 → 186
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14643
    Location:240 → 388
    DSP_DUSP7; dual specificity phosphatase domain of dual specificity protein phosphatase 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    52048919..52056571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    52081823..52089474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16829.4 GenPept UniProtKB/Swiss-Prot:Q16829

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous