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P2ry2 purinergic receptor P2Y, G-protein coupled 2 [ Mus musculus (house mouse) ]

Gene ID: 18442, updated on 11-Apr-2024

Summary

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Official Symbol
P2ry2provided by MGI
Official Full Name
purinergic receptor P2Y, G-protein coupled 2provided by MGI
Primary source
MGI:MGI:105107
See related
Ensembl:ENSMUSG00000032860 AllianceGenome:MGI:105107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2U1; P2Y2
Summary
Predicted to enable A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Acts upstream of or within positive regulation of mucus secretion. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to colocalize with early endosome; lysosome; and mitochondrion. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 12.3), small intestine adult (RPKM 10.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See P2ry2 in Genome Data Viewer
Location:
7 E2; 7 54.47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100645775..100661260, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100996568..101012053, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8191 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102 Neighboring gene STARR-seq mESC enhancer starr_19682 Neighboring gene STARR-seq mESC enhancer starr_19683 Neighboring gene STARR-seq mESC enhancer starr_19684 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 6 Neighboring gene STARR-seq mESC enhancer starr_19685 Neighboring gene STARR-positive B cell enhancer ABC_E1348 Neighboring gene STARR-positive B cell enhancer ABC_E11362 Neighboring gene STARR-positive B cell enhancer ABC_E4956 Neighboring gene STARR-positive B cell enhancer ABC_E8192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108241274-108241427 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11363 Neighboring gene STARR-positive B cell enhancer mm9_chr7:108256776-108257077 Neighboring gene FCH and double SH3 domains 2 Neighboring gene ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A purinergic mechanism underlying metformin regulation of hyperglycemia. Senfeld J, et al. iScience, 2023 Jun 16. PMID 37378329, Free PMC Article
  2. P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC. Chen M, et al. BMC Musculoskelet Disord, 2021 Aug 11. PMID 34380439, Free PMC Article
  3. P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. Dusabimana T, et al. Int J Mol Sci, 2021 May 24. PMID 34073834, Free PMC Article
  4. P2Y(2) deficiency impacts adult neurogenesis and related forebrain functions. Ali AAH, et al. FASEB J, 2021 May. PMID 33817825
  5. P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response. Dusabimana T, et al. Mol Metab, 2020 Dec. PMID 32987187, Free PMC Article

See all (150) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
    Title: P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality.
  2. The P2Y2 receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
    Title: The P2Y(2) receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode.
  3. P2Y2-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-kappaB signaling favoring mononuclear cell adhesion in schistosomiasis.
    Title: P2Y(2)-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis.
  4. P2Y2 receptor decreases blood pressure by inhibiting ENaC.
    Title: P2Y2 receptor decreases blood pressure by inhibiting ENaC.
  5. Deletion of the P2Y2 receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
    Title: Deletion of the P2Y(2) receptor aggravates internal elastic lamina calcification in chronic kidney disease mice through upregulation of alkaline phosphatase and lipocalin-2.
  6. Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
    Title: Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
  7. Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
    Title: Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice.
  8. P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
    Title: P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response.
  9. P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
    Title: P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC.
  10. P2Y2 deficiency impacts adult neurogenesis and related forebrain functions.
    Title: P2Y(2) deficiency impacts adult neurogenesis and related forebrain functions.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables A1 adenosine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables A1 adenosine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled UTP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled UTP receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 2
Names
ATP receptor
P2U purinoceptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302346.1 → NP_001289275.1  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_001289275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC151414, AK005013
    Consensus CDS
    CCDS21508.1
    UniProtKB/Swiss-Prot
    O09031, P35383, Q9CPZ4
    UniProtKB/TrEMBL
    A0A0R4J289
    Related
    ENSMUSP00000146352.2, ENSMUST00000207916.2
    Conserved Domains (1) summary
    pfam00001
    Location:51 → 306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001302347.1 → NP_001289276.1  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_001289276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC151414, AK005013, AK017378
    Consensus CDS
    CCDS21508.1
    UniProtKB/Swiss-Prot
    O09031, P35383, Q9CPZ4
    UniProtKB/TrEMBL
    A0A0R4J289
    Related
    ENSMUSP00000137152.2, ENSMUST00000178340.3
    Conserved Domains (1) summary
    pfam00001
    Location:51 → 306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_008773.4 → NP_032799.2  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_032799.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC151414, AK005013, AK017378
    Consensus CDS
    CCDS21508.1
    UniProtKB/Swiss-Prot
    O09031, P35383, Q9CPZ4
    UniProtKB/TrEMBL
    A0A0R4J289
    Related
    ENSMUSP00000036765.4, ENSMUST00000037540.5
    Conserved Domains (1) summary
    pfam00001
    Location:51 → 306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    100645775..100661260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35383.1 GenPept UniProtKB/Swiss-Prot:P35383

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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