P2ry1 purinergic receptor P2Y, G-protein coupled 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry1provided by MGI
Official Full Name: purinergic receptor P2Y, G-protein coupled 1provided by MGI
Primary source: MGI:MGI:105049
See related: Ensembl:ENSMUSG00000027765 AllianceGenome:MGI:105049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2Y1; P2y1r
Summary: Predicted to enable several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Acts upstream of or within cellular response to organic cyclic compound and positive regulation of ion transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and liver and biliary system. Orthologous to human P2RY1 (purinergic receptor P2Y1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 5.3), large intestine adult (RPKM 4.9) and 27 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3 E1; 3 29.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (60910206..60916403)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (61002785..61008982)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of P2Y1 receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro.
Title: Loss of P2Y(1) receptor desensitization does not impact hemostasis or thrombosis despite increased platelet reactivity in vitro.
P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner.
Title: P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner.
Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release.
Title: Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release.
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors.
Title: BAC transgenic mice to study the expression of P2X2 and P2Y(1) receptors.
ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation.
Title: ADP/P2Y(1) aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation.
Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
Title: Preserved Calretinin Interneurons in an App Model of Alzheimer's Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors.
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Title: Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Study demonstrates that the metabotropic P2Y1 receptor mediates either proconvulsive or anticonvulsive responses, dependent on the time point of activation in relation to the induction of status epilepticus.
Title: Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y(1) Receptor in Experimental Epilepsy.
microglial P2Y1R mediate neuroprotective effects against ischemic stress and oxygen-glucose deprivation insult.
Title: Neuroprotective effects of microglial P2Y(1) receptors against ischemic neuronal injury.
Energy depletion and ADP elevation in sensory afferents, due to mitochondrial respiratory chain complex IV deficiency, appear sufficient to induce pain hypersensitivity, by ADP activation of P2Y1 receptors.
Title: A Targeted Mutation Disrupting Mitochondrial Complex IV Function in Primary Afferent Neurons Leads to Pain Hypersensitivity Through P2Y(1) Receptor Activation.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

Go to the top of the page Help

Markers

U22829 (e-PCR)
- UniSTS:125701

PMC34459P1 (e-PCR)
- UniSTS:273207

P2ry1 (e-PCR), detects polymorphism
- UniSTS:144109

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables A1 adenosine receptor binding	ISO Inferred from Sequence Orthology more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled ADP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled ATP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ATP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of monoatomic ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of monoatomic ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in relaxation of muscle	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: P2Y purinoceptor 1

Names: ADP receptor; ATP receptor; P2Y1 receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282016.1 → NP_001268945.1 P2Y purinoceptor 1

See identical proteins and their annotated locations for NP_001268945.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK030759, AK033660, BY780693

Consensus CDS

CCDS17377.1

UniProtKB/Swiss-Prot

P49650

UniProtKB/TrEMBL

Q544J5, Q8BMJ5

Related

ENSMUSP00000142006.2, ENSMUST00000193201.2

Conserved Domains (1) summary

pfam00001
Location:68 → 324

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_008772.5 → NP_032798.1 P2Y purinoceptor 1

See identical proteins and their annotated locations for NP_032798.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK030759, AK033660, AK036611, BY780693

Consensus CDS

CCDS17377.1

UniProtKB/Swiss-Prot

P49650

UniProtKB/TrEMBL

Q544J5, Q8BMJ5

Related

ENSMUSP00000029331.2, ENSMUST00000029331.7

Conserved Domains (1) summary

pfam00001
Location:68 → 324

7tm_1; 7 transmembrane receptor (rhodopsin family)