Oprm1 opioid receptor, mu 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oprm1provided by MGI
Official Full Name: opioid receptor, mu 1provided by MGI
Primary source: MGI:MGI:97441
See related: Ensembl:ENSMUSG00000000766 AllianceGenome:MGI:97441
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O
Summary: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 1.85 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (6708593..6988209)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (6758593..7038209)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells.
Title: Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells.
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to mu-opioidergic cell types.
Title: Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1alpha/KCNQ1OT1 axis.
Title: Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1α/KCNQ1OT1 axis.
Characterization and mu opioid receptor sensitivity of neuropeptide Y interneurons in the mouse nucleus accumbens.
Title: Characterization and mu opioid receptor sensitivity of neuropeptide Y interneurons in the mouse nucleus accumbens.
Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Title: Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Novel role of the Mu-opioid receptor in pancreatic cancer: potential link between opioid use and cancer progression.
Title: Novel role of the Mu-opioid receptor in pancreatic cancer: potential link between opioid use and cancer progression.
Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1.
Title: Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1.
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
Title: Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
Title: A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.
Title: Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.

Submit: New GeneRIF Correction See all GeneRIFs (208)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (34) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC61171P1 (e-PCR)
- UniSTS:273412

NoName (e-PCR)
- UniSTS:236303

NoName (e-PCR)
- UniSTS:487446

RH94842 (e-PCR)
- UniSTS:120088

ha3034 (e-PCR)
- UniSTS:515627

D10Mit75 (e-PCR), detects polymorphism
- UniSTS:126257

U19380 (e-PCR)
- UniSTS:159948

U19380 (e-PCR)
- UniSTS:125690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled opioid receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables beta-endorphin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-endorphin receptor activity	ISO Inferred from Sequence Orthology more info
enables morphine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables morphine receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in sperm ejaculation	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with T-tubule	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with sarcolemma	ISO Inferred from Sequence Orthology more info
colocalizes_with sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in spine apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mu-type opioid receptor

Names: MOP receptor; mu opioid receptor MOR-1BI; mu opioid receptor MOR-1P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039652.2 → NP_001034741.1 mu-type opioid receptor isoform MOR-1C

See identical proteins and their annotated locations for NP_001034741.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1C) lacks an exon in the 3' coding region, compared to variant MOR-1U. The resulting isoform (MOR-1C), is shorter than isoform MOR-1U.

Source sequence(s)

AC153981, AF062753, AK038389

Consensus CDS

CCDS56687.1

UniProtKB/TrEMBL

E9Q7D4

Related

ENSMUSP00000101236.2, ENSMUST00000105611.8

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001302793.1 → NP_001289722.1 mu-type opioid receptor isoform MOR-1

See identical proteins and their annotated locations for NP_001289722.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1) lacks several 3' coding exons and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1) has a shorter and distinct C-terminus compared to isoform MOR-1U. This variant likely represents the major transcript of this gene.

Source sequence(s)

AC153981, AC164171, AF062753

Consensus CDS

CCDS78787.1

UniProtKB/Swiss-Prot

A1XGX3, A1XGX4, A1YAC3, A1YAC4, A5H7G2, P42866, Q4U2P4, Q4U2Q6, Q548C6, Q60768, Q6YC50, Q8CAN5, Q8CGW2, Q8CH73, Q8CH74, Q8CH75, Q8VBU3, Q8VBU6, Q8VBX8, Q8VI69, Q8VI70, Q8VI71, Q8VIN3, Q8VIN4, Q8VIN5, Q8VIN6, Q8VIP0, Q8VIP1, Q9JIY1, Q9R0D1, Q9R1L9, Q9R1M0

UniProtKB/TrEMBL

B6ZJY0

Related

ENSMUSP00000101232.2, ENSMUST00000105607.8

Conserved Domains (1) summary

cd15090
Location:69 → 347

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001302794.1 → NP_001289723.1 mu-type opioid receptor isoform MOR-1G

See identical proteins and their annotated locations for NP_001289723.1

Status: REVIEWED

Description

Transcript Variant: has an alternate exon in place of the 5'-most exon, lacks several 3' coding exons, and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1G) has shorter and distinct N- and C-termini compared to isoform MOR-1U.

Source sequence(s)

AC164171, AF062755

Consensus CDS

CCDS78783.1

UniProtKB/TrEMBL

Q91ZZ4

Related

ENSMUSP00000117950.2, ENSMUST00000147171.8

Conserved Domains (2) summary

pfam00001
Location:26 → 268

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:24 → 213

7tm_4; Olfactory receptor
NM_001302795.1 → NP_001289724.1 mu-type opioid receptor isoform MOR-1M

See identical proteins and their annotated locations for NP_001289724.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1M) has an alternate exon in place of the 5'-most exon compared to MOR-1U. The resulting isoform (MOR-1M) has a shorter and distinct N-terminus compared to isoform MOR-1U.

Source sequence(s)

AF062755, AK038389

Consensus CDS

CCDS78784.1

UniProtKB/Swiss-Prot

P42866

Related

ENSMUSP00000101240.3, ENSMUST00000105615.9

Conserved Domains (2) summary

pfam00001
Location:26 → 268

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:24 → 213

7tm_4; Olfactory receptor
NM_001302796.1 → NP_001289725.1 mu-type opioid receptor isoform MOR-1N

See identical proteins and their annotated locations for NP_001289725.1

Status: REVIEWED

Description

Transcript Variant: has an alternate exon in place of the 5'-most exon and lacks an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1N) has shorter and distinct N- and C-termini compared to isoform MOR-1U.

Source sequence(s)

AF062755, AK038389

Consensus CDS

CCDS78785.1

UniProtKB/TrEMBL

Q91ZZ4

Related

ENSMUSP00000053498.8, ENSMUST00000063036.14

Conserved Domains (2) summary

pfam00001
Location:26 → 268

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:24 → 213

7tm_4; Olfactory receptor
NM_001304937.1 → NP_001291866.1 mu-type opioid receptor isoform MOR-1A

See identical proteins and their annotated locations for NP_001291866.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1A) lacks 3' exons and its 3' terminal exon extends past a splice site that is used in variant MOR-1U. It encodes isoform MOR-1A which is shorter and has a distinct C-terminus, compared to isoform MOR-1U.

Source sequence(s)

AC153981

Consensus CDS

CCDS83674.1

UniProtKB/TrEMBL

E9Q7D4

Related

ENSMUSP00000101227.2, ENSMUST00000105602.8

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304938.1 → NP_001291867.1 mu-type opioid receptor isoform MOR-1B1

See identical proteins and their annotated locations for NP_001291867.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B1) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.

Source sequence(s)

AC153981, AC164171

Consensus CDS

CCDS83673.1

UniProtKB/TrEMBL

E9Q7D4

Related

ENSMUSP00000101230.2, ENSMUST00000105605.8

Conserved Domains (1) summary

cd15090
Location:69 → 347

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001304948.1 → NP_001291877.1 mu-type opioid receptor isoform MOR-1B2

See identical proteins and their annotated locations for NP_001291877.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B2) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.

Source sequence(s)

AC153981, AC164171

Consensus CDS

CCDS83672.1

UniProtKB/TrEMBL

E9Q7D4

Related

ENSMUSP00000114342.2, ENSMUST00000154906.8

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304950.1 → NP_001291879.1 mu-type opioid receptor isoform MOR-1D

See identical proteins and their annotated locations for NP_001291879.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1D) differs in the 3' UTR and has multiple coding region differences, compared to variant MOR-1U, one of which results in a frameshift. The resulting protein (isoform MOR-1D) has a distinct C-terminus and is shorter than isoform MOR-1U.

Source sequence(s)

AC153981, AC155718

Consensus CDS

CCDS78788.1

UniProtKB/TrEMBL

E9Q7D4

Related

ENSMUSP00000060329.8, ENSMUST00000052751.14

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor
NM_001304955.1 → NP_001291884.1 mu-type opioid receptor isoform MOR-1U

See identical proteins and their annotated locations for NP_001291884.1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1U) encodes the longest isoform (MOR-1U).

Source sequence(s)

AC153981, AC155718

UniProtKB/TrEMBL

E9Q7D4

Conserved Domains (2) summary

pfam00001
Location:85 → 336

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 281

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

6708593..6988209

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512437.5 → XP_006512500.1 mu-type opioid receptor isoform X1

UniProtKB/TrEMBL

E9Q7D4

Conserved Domains (1) summary

cd15090
Location:69 → 347

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017313827.3 → XP_017169316.1 mu-type opioid receptor isoform X3

UniProtKB/TrEMBL

E9Q7D3

Related

ENSMUSP00000000783.7, ENSMUST00000000783.13

Conserved Domains (1) summary

cd15090
Location:69 → 347

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017313826.3 → XP_017169315.1 mu-type opioid receptor isoform X2

UniProtKB/TrEMBL

A0A0R4J0Z2, E9Q7D4

Related

ENSMUSP00000077704.6, ENSMUST00000078634.12

Conserved Domains (1) summary

cd15090
Location:69 → 347

7tmA_Mu_opioid_R; opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017313828.1 → XP_017169317.1 mu-type opioid receptor isoform X4

UniProtKB/TrEMBL

A1KZZ4

Related

ENSMUSP00000120187.2, ENSMUST00000123861.8

Conserved Domains (2) summary

cd14964
Location:71 → 95

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:69 → 100

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017313829.2 → XP_017169318.1 mu-type opioid receptor isoform X5

Conserved Domains (2) summary

cd14964
Location:70 → 96

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:69 → 96

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_011013.1: Suppressed sequence

Description

NM_011013.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.