Omp olfactory marker protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ompprovided by MGI
Official Full Name: olfactory marker proteinprovided by MGI
Primary source: MGI:MGI:97436
See related: Ensembl:ENSMUSG00000074006 AllianceGenome:MGI:97436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable peptide binding activity. Acts upstream of or within neurogenesis and sensory perception of smell. Located in several cellular components, including axon; cytosol; and neuronal cell body. Is expressed in several structures, including brain; eye; genitourinary system; intestine; and olfactory system. Orthologous to human OMP (olfactory marker protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.59 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (97792566..97794654, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (98143359..98145447, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olfactory marker protein regulates adipogenesis via the cAMP-IkappaBalpha pathway.
Title: Olfactory marker protein regulates adipogenesis via the cAMP-IκBα pathway.
Olfactory marker protein contributes to the evaluation of odour values by olfactory glomerular processing.
Title: Olfactory marker protein contributes to the evaluation of odour values by olfactory glomerular processing.
Olfactory marker protein elevates basal cAMP concentration.
Title: Olfactory marker protein elevates basal cAMP concentration.
Oolfactory receptor neurons express OMP but not CAPN5 from CAPN5 gene expression even though they are localized in the same genomic locus.
Title: Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.
Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map
Title: Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map.
This study demonstrated that the OMP plays a key regulatory role in Olfactory Receptor Neurons physiology by controlling multiple facets of the odorant response.
Title: The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.
Three olfactory receptors (olfr544, olfr558, and olfr1386) were expressed in the olfactory marker protein (+) cells of the bladder and thyroid.
Title: Olfactory marker protein expression is an indicator of olfactory receptor-associated events in non-olfactory tissues.
the actions of OMP in olfactory transduction carry through to the primary sensory representations of olfactory stimuli in adult mice in vivo.
Title: Spatiotemporal alterations in primary odorant representations in olfactory marker protein knockout mice.
results indicate that the primary sensory inputs to the olfactory system of the brain exhibit robust experience-dependent plasticity in adult mice specific to the environmental stimuli experienced.
Title: Odor-specific, olfactory marker protein-mediated sparsening of primary olfactory input to the brain after odor exposure.
Olfactory sensory neurons undergo an olfactory marker protein-dependent functional maturation process that coincides with early development of the smell function, which is essential for pups to form preference for their mother.
Title: Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (14) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Omp (e-PCR), detects polymorphism
- UniSTS:144083

D1Mgh19 (e-PCR)
- UniSTS:118493

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: olfactory marker protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.