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Ogg1 8-oxoguanine DNA-glycosylase 1 [ Mus musculus (house mouse) ]

Gene ID: 18294, updated on 11-Apr-2024

Summary

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Official Symbol
Ogg1provided by MGI
Official Full Name
8-oxoguanine DNA-glycosylase 1provided by MGI
Primary source
MGI:MGI:1097693
See related
Ensembl:ENSMUSG00000030271 AllianceGenome:MGI:1097693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mmh
Summary
Enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity and microtubule binding activity. Acts upstream of or within base-excision repair. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 11.9), ovary adult (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 52.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113303959..113311149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113326972..113334877)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene copine family member IX Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene STARR-positive B cell enhancer ABC_E237 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene STARR-positive B cell enhancer ABC_E1326 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury. Pan L, et al. Nucleic Acids Res, 2023 Feb 22. PMID 36651270, Free PMC Article
  2. DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development. Bhatia S, et al. Toxicol Sci, 2022 Apr 26. PMID 35038743
  3. Oxidative Stress, Mutations and Chromosomal Aberrations Induced by In Vitro and In Vivo Exposure to Furan. Russo MT, et al. Int J Mol Sci, 2021 Sep 7. PMID 34575853, Free PMC Article
  4. A Novel Role for the DNA Repair Enzyme 8-Oxoguanine DNA Glycosylase in Adipogenesis. Komakula SSB, et al. Int J Mol Sci, 2021 Jan 25. PMID 33503804, Free PMC Article
  5. OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†. Mori Y, et al. Biol Reprod, 2021 Mar 11. PMID 33252132

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Catalytic activity of OGG1 is impaired by Zinc deficiency.
    Title: Catalytic activity of OGG1 is impaired by Zinc deficiency.
  2. OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
    Title: OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
  3. 8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-kappaB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276.
    Title: 8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276.
  4. Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1.
    Title: Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1.
  5. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
    Title: Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1.
  6. 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury.
    Title: 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury.
  7. Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
    Title: Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases.
  8. DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development.
    Title: DNA Damage and Repair and Epigenetic Modification in the Role of Oxoguanine Glycosylase 1 in Brain Development.
  9. OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culturedagger.
    Title: OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.
  10. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
    Title: MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA N-glycosylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidized base lesion DNA N-glycosylase activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidized purine nucleobase lesion DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within DNA repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair, AP site formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of double-strand break repair via single-strand annealing ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
N-glycosylase/DNA lyase
NP_001397059.1
NP_001397060.1
NP_001397061.1
NP_035087.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410130.1 → NP_001397059.1  N-glycosylase/DNA lyase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155287

  2. NM_001410131.1 → NP_001397060.1  N-glycosylase/DNA lyase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC155287

  3. NM_001410132.1 → NP_001397061.1  N-glycosylase/DNA lyase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC155287

  4. NM_010957.5 → NP_035087.3  N-glycosylase/DNA lyase isoform 1

    See identical proteins and their annotated locations for NP_035087.3

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Consensus CDS
    CCDS20414.1
    UniProtKB/Swiss-Prot
    O08733, O08760, O08910, O08991, O35617, O35915, Q9QXE8
    UniProtKB/TrEMBL
    Q3UIL3
    Related
    ENSMUSP00000032406.9, ENSMUST00000032406.15
    Conserved Domains (3) summary
    TIGR00588
    Location:11 → 328
    ogg; 8-oxoguanine DNA-glycosylase (ogg)
    cd00056
    Location:139 → 319
    ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
    pfam07934
    Location:25 → 141
    OGG_N; 8-oxoguanine DNA glycosylase, N-terminal domain

RNA

  1. NR_149720.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Related
    ENSMUST00000136263.4

  2. NR_176953.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Related
    ENSMUST00000204834.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113303959..113311149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08760.2 GenPept UniProtKB/Swiss-Prot:O08760

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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