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Ocm oncomodulin [ Mus musculus (house mouse) ]

Gene ID: 18261, updated on 5-Mar-2024

Summary

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Official Symbol
Ocmprovided by MGI
Official Full Name
oncomodulinprovided by MGI
Primary source
MGI:MGI:97401
See related
Ensembl:ENSMUSG00000029618 AllianceGenome:MGI:97401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium ion binding activity and protein homodimerization activity. Predicted to be involved in positive regulation of axon regeneration; positive regulation of retinal ganglion cell axon guidance; and response to wounding. Predicted to be located in several cellular components, including cuticular plate; extracellular space; and stereocilium. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in utricle. Orthologous to several human genes including OCM2 (oncomodulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 9.7) and small intestine adult (RPKM 3.3) See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 82.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143956615..143987691, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144019807..144050640, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene STARR-positive B cell enhancer ABC_E6396 Neighboring gene predicted gene, 24311 Neighboring gene predicted gene, 54312 Neighboring gene predicted gene, 33427 Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene STARR-seq mESC enhancer starr_14800 Neighboring gene STARR-positive B cell enhancer ABC_E1061 Neighboring gene lemur tyrosine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:144923715-144923898

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and chromosomal localization of the mouse oncomodulin gene. Staubli F, et al. Mamm Genome, 1995 Nov. PMID 8597631
  2. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice. Niemi JP, et al. eNeuro, 2022 Jan-Feb. PMID 35131866, Free PMC Article
  3. Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice. Climer LK, et al. Front Aging Neurosci, 2021. PMID 34867279, Free PMC Article
  4. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. de Lima S, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22615390, Free PMC Article
  5. Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice. Csillik B, et al. Neuroscience, 2010 Feb 3. PMID 19874871

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.
    Title: Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.
  2. Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.
    Title: Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.
  3. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice.
    Title: The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice.
  4. These data suggest that Ocm may have distinct functional roles in cochlear and vestibular hair cells.
    Title: Oncomodulin identifies different hair cell types in the mammalian inner ear.
  5. absence of parvalbumin has no major effect on the GABA-synthesizing system in diencephalon presynaptic terminals; however, a likely homeostatic mechanism is induced resulting in the upregulation of oncomodulin in selected axons and neuronal perikarya
    Title: Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cuticular plate ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
  
located_in supramolecular fiber ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oncomodulin
Names
OM
parvalbumin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033039.3 → NP_149028.2  oncomodulin

    See identical proteins and their annotated locations for NP_149028.2

    Status: VALIDATED

    Source sequence(s)
    AC121917
    Consensus CDS
    CCDS51693.1
    UniProtKB/Swiss-Prot
    P51879, Q62004
    Related
    ENSMUSP00000031622.7, ENSMUST00000031622.13
    Conserved Domains (1) summary
    cd16255
    Location:9 → 109
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143956615..143987691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241003.2 → XP_011239305.1  oncomodulin isoform X1

    See identical proteins and their annotated locations for XP_011239305.1

    Conserved Domains (1) summary
    cd16255
    Location:9 → 103
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

  2. XM_011241004.2 → XP_011239306.1  oncomodulin isoform X1

    See identical proteins and their annotated locations for XP_011239306.1

    Conserved Domains (1) summary
    cd16255
    Location:9 → 103
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

  3. XM_011241005.4 → XP_011239307.1  oncomodulin isoform X1

    See identical proteins and their annotated locations for XP_011239307.1

    Conserved Domains (1) summary
    cd16255
    Location:9 → 103
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin

  4. XM_036164868.1 → XP_036020761.1  oncomodulin isoform X1

    Conserved Domains (1) summary
    cd16255
    Location:9 → 103
    EFh_parvalbumin_beta; EF-hand, calcium binding motif, found in beta-parvalbumin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51879.2 GenPept UniProtKB/Swiss-Prot:P51879

Gene LinkOut

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