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Nsg1 neuron specific gene family member 1 [ Mus musculus (house mouse) ]

Gene ID: 18196, updated on 11-Apr-2024

Summary

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Official Symbol
Nsg1provided by MGI
Official Full Name
neuron specific gene family member 1provided by MGI
Primary source
MGI:MGI:109149
See related
Ensembl:ENSMUSG00000029126 AllianceGenome:MGI:109149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p21; m234; Neep21
Summary
Predicted to enable clathrin light chain binding activity and signaling receptor binding activity. Involved in several processes, including amyloid precursor protein metabolic process; neurotransmitter receptor transport; and receptor recycling. Located in several cellular components, including glutamatergic synapse; late endosome; and lateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human NSG1 (neuronal vesicle trafficking associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 286.0), cerebellum adult (RPKM 209.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Nsg1 in Genome Data Viewer
Location:
5 B3; 5 20.21 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38294537..38317087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38137193..38159743, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12911 Neighboring gene STARR-seq mESC enhancer starr_12912 Neighboring gene predicted gene, 54328 Neighboring gene VISTA enhancer mm429 Neighboring gene predicted gene, 40289 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38414144-38414444 Neighboring gene syntaxin 18 Neighboring gene VISTA enhancer mm1165 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38602912-38603212 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene Ly1 antibody reactive clone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Global loss of Neuron-specific gene 1 causes alterations in motor coordination, increased anxiety, and diurnal hyperactivity in male mice. Austin R, et al. Genes Brain Behav, 2022 Jul. PMID 35577358, Free PMC Article
  2. A 21-kDa polypeptide belonging to a new family of proteins is expressed in the Golgi apparatus of neural and germ cells. Sabéran-Djoneidi D, et al. J Biol Chem, 1998 Feb 13. PMID 9461575
  3. Crucial role of neuron-enriched endosomal protein of 21 kDa in sorting between degradation and recycling of internalized G-protein-coupled receptors. Debaigt C, et al. J Biol Chem, 2004 Aug 20. PMID 15187090
  4. Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons. Carlock L, et al. Brain Res Mol Brain Res, 1996 Dec. PMID 9013775
  5. The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes. Yap CC, et al. Sci Rep, 2017 Sep 5. PMID 28874679, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development.
    Title: The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.
  2. Expression of Nsg1 in the mouse nucleus accumbens is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
    Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amyloid precursor protein metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter receptor cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuronal vesicle trafficking-associated protein 1
Names
brain neuron cytoplasmic protein 1
neuron-enriched endosomal protein of 21 kDa
neuron-specific protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359090.1 → NP_001346019.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    O54717, Q3UF63, Q62092, Q922E5
    UniProtKB/TrEMBL
    Q8C5M2
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  2. NM_001359091.1 → NP_001346020.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    O54717, Q3UF63, Q62092, Q922E5
    UniProtKB/TrEMBL
    Q8C5M2
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  3. NM_001359092.1 → NP_001346021.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    O54717, Q3UF63, Q62092, Q922E5
    UniProtKB/TrEMBL
    Q8C5M2
    Related
    ENSMUSP00000144396.2, ENSMUST00000201363.4
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

  4. NM_010942.4 → NP_035072.2  neuronal vesicle trafficking-associated protein 1

    See identical proteins and their annotated locations for NP_035072.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931, AK076451, AK148941
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    O54717, Q3UF63, Q62092, Q922E5
    UniProtKB/TrEMBL
    Q8C5M2
    Related
    ENSMUSP00000031009.5, ENSMUST00000031009.8
    Conserved Domains (1) summary
    pfam06387
    Location:1 → 180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38294537..38317087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62092.3 GenPept UniProtKB/Swiss-Prot:Q62092

Gene LinkOut

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