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Nrf1 nuclear respiratory factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18181, updated on 11-Apr-2024

Summary

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Official Symbol
Nrf1provided by MGI
Official Full Name
nuclear respiratory factor 1provided by MGI
Primary source
MGI:MGI:1332235
See related
Ensembl:ENSMUSG00000058440 AllianceGenome:MGI:1332235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D6Ertd415e
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within mitochondrion organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; connective tissue; genitourinary system; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.3), CNS E11.5 (RPKM 6.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.47 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30047984..30153462)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30047985..30153458)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52897 Neighboring gene predicted gene, 31103 Neighboring gene smal lysine rich protein 1, pseudogene Neighboring gene STARR-seq mESC enhancer starr_15453 Neighboring gene microRNA cluster 35, host gene Neighboring gene microRNA 182 Neighboring gene microRNA 96

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Nuclear respiratory factor 1 mediates LPS-induced acute lung injury through NF-κB]. Cheng K, et al. Sheng Li Xue Bao, 2022 Jun 25. PMID 35770638
  2. NRF1-mediated microglial activation triggers high-altitude cerebral edema. Wang X, et al. J Mol Cell Biol, 2022 Sep 19. PMID 35704676, Free PMC Article
  3. Nrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues. Yuan J, et al. Int J Mol Sci, 2018 Sep 27. PMID 30261697, Free PMC Article
  4. NRF1 coordinates with DNA methylation to regulate spermatogenesis. Wang J, et al. FASEB J, 2017 Nov. PMID 28754714, Free PMC Article
  5. Effect of cellular ubiquitin levels on the regulation of oxidative stress response and proteasome function via Nrf1. Lee D, et al. Biochem Biophys Res Commun, 2017 Apr 1. PMID 28237703

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m[6] A methylation through upregulation of METTL3 transcription.
    Title: NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m(6) A methylation through upregulation of METTL3 transcription.
  2. Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
    Title: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.
  3. Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload.
    Title: Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload.
  4. miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
    Title: miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb the Proliferation and Functions of Chondrocytes.
  5. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.
    Title: Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.
  6. NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
    Title: NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
  7. Euglycemia is affected by stress defense factor hepatocyte NRF1, but not NRF2.
    Title: Euglycemia is affected by stress defense factor hepatocyte NRF1, but not NRF2.
  8. NRF1-mediated microglial activation triggers high-altitude cerebral edema.
    Title: NRF1-mediated microglial activation triggers high-altitude cerebral edema.
  9. [Nuclear respiratory factor 1 mediates LPS-induced acute lung injury through NF-kappaB].
    Title: [Nuclear respiratory factor 1 mediates LPS-induced acute lung injury through NF-κB].
  10. Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks.
    Title: Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
nuclear respiratory factor 1
Names
NRF-1
alpha palindromic-binding protein
alpha-pal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164226.2 → NP_001157698.1  nuclear respiratory factor 1 isoform a

    See identical proteins and their annotated locations for NP_001157698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 6, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS19968.1
    UniProtKB/Swiss-Prot
    Q9CXE4, Q9WU00
    UniProtKB/TrEMBL
    Q8C4C0
    Related
    ENSMUSP00000110866.2, ENSMUST00000115211.8
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  2. NM_001164227.2 → NP_001157699.1  nuclear respiratory factor 1 isoform b

    See identical proteins and their annotated locations for NP_001157699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and longer C-terminus in isoform b, compared to isoform a. Variants 2, 7, 13, and 14 all encode the same isoform (b).
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS51741.1
    UniProtKB/TrEMBL
    Q8CAV3, Q99K73
    Related
    ENSMUSP00000110860.2, ENSMUST00000115206.8
    Conserved Domains (2) summary
    cd04867
    Location:450 → 525
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  3. NM_001164228.2 → NP_001157700.1  nuclear respiratory factor 1 isoform c

    See identical proteins and their annotated locations for NP_001157700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, lacks a 3' coding exon, and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and shorter C-terminus in isoform c, compared to isoform a.
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS51742.1
    UniProtKB/TrEMBL
    D3Z3B4, G3XA39
    Related
    ENSMUSP00000110858.2, ENSMUST00000115204.8
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  4. NM_001164229.2 → NP_001157701.1  nuclear respiratory factor 1 isoform d

    See identical proteins and their annotated locations for NP_001157701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR, contains an alternate 5' coding exon, and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and longer C-terminus in isoform d, compared to isoform a. Variants 4 and 15 both encode the same isoform (d).
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS51739.1
    UniProtKB/TrEMBL
    Q3UXF4, Q3UYQ3
    Related
    ENSMUSP00000110853.2, ENSMUST00000115199.8
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  5. NM_001164230.2 → NP_001157702.1  nuclear respiratory factor 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR and contains an alternate exon in the 3' coding region which results in a frameshift and early stop codon, compared to variant 1. This results in a distinct and shorter C-terminus in isoform e, compared to isoform a. Variants 5 and 16 both encode the same isoform (e).
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS51740.1
    UniProtKB/TrEMBL
    E9Q7X0, Q3UYQ3
    Related
    ENSMUSP00000110854.2, ENSMUST00000115200.8
    Conserved Domains (1) summary
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  6. NM_001361692.2 → NP_001348621.1  nuclear respiratory factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153632
    Consensus CDS
    CCDS51741.1
    UniProtKB/TrEMBL
    Q8CAV3, Q99K73
    Conserved Domains (2) summary
    cd04867
    Location:450 → 525
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  7. NM_001361693.2 → NP_001348622.1  nuclear respiratory factor 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC153632
    UniProtKB/TrEMBL
    Q8C4C0
    Conserved Domains (2) summary
    pfam10492
    Location:462 → 505
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  8. NM_001361694.2 → NP_001348623.1  nuclear respiratory factor 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153632
    Consensus CDS
    CCDS19968.1
    UniProtKB/Swiss-Prot
    Q9CXE4, Q9WU00
    UniProtKB/TrEMBL
    Q8C4C0
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  9. NM_001361695.2 → NP_001348624.1  nuclear respiratory factor 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC153632
    Consensus CDS
    CCDS19968.1
    UniProtKB/Swiss-Prot
    Q9CXE4, Q9WU00
    UniProtKB/TrEMBL
    Q8C4C0
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  10. NM_001410221.1 → NP_001397150.1  nuclear respiratory factor 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  11. NM_001410222.1 → NP_001397151.1  nuclear respiratory factor 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  12. NM_001410223.1 → NP_001397152.1  nuclear respiratory factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632
    UniProtKB/TrEMBL
    Q99K73

  13. NM_001410224.1 → NP_001397153.1  nuclear respiratory factor 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC153632
    UniProtKB/TrEMBL
    Q99K73

  14. NM_001410225.1 → NP_001397154.1  nuclear respiratory factor 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632
    UniProtKB/TrEMBL
    Q3UXF4
    Related
    ENSMUSP00000067447.9, ENSMUST00000069831.15

  15. NM_001410226.1 → NP_001397155.1  nuclear respiratory factor 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632
    UniProtKB/TrEMBL
    E9Q7X0
    Related
    ENSMUSP00000004761.7, ENSMUST00000004761.13

  16. NM_001410227.1 → NP_001397156.1  nuclear respiratory factor 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  17. NM_001410228.1 → NP_001397157.1  nuclear respiratory factor 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  18. NM_001410229.1 → NP_001397158.1  nuclear respiratory factor 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  19. NM_001410230.1 → NP_001397159.1  nuclear respiratory factor 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  20. NM_001410231.1 → NP_001397160.1  nuclear respiratory factor 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632
    Related
    ENSMUSP00000110863.2, ENSMUST00000115208.8

  21. NM_001410232.1 → NP_001397161.1  nuclear respiratory factor 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  22. NM_001410233.1 → NP_001397162.1  nuclear respiratory factor 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  23. NM_001410234.1 → NP_001397163.1  nuclear respiratory factor 1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  24. NM_001410235.1 → NP_001397164.1  nuclear respiratory factor 1 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC134897, AC153632

  25. NM_010938.5 → NP_035068.3  nuclear respiratory factor 1 isoform a

    See identical proteins and their annotated locations for NP_035068.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 6, 9, and 10 all encode the same isoform (a).
    Source sequence(s)
    AC134897, AC153632
    Consensus CDS
    CCDS19968.1
    UniProtKB/Swiss-Prot
    Q9CXE4, Q9WU00
    UniProtKB/TrEMBL
    Q8C4C0
    Related
    ENSMUSP00000110867.2, ENSMUST00000115212.8
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30047984..30153462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255218.2 → XP_030111078.1  nuclear respiratory factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q9CXE4, Q9WU00
    UniProtKB/TrEMBL
    Q8C4C0
    Conserved Domains (2) summary
    pfam10492
    Location:450 → 493
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  2. XM_017321441.3 → XP_017176930.1  nuclear respiratory factor 1 isoform X2

    UniProtKB/TrEMBL
    Q8CAV3, Q99K73
    Conserved Domains (2) summary
    cd04867
    Location:450 → 525
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  3. XM_030255217.2 → XP_030111077.1  nuclear respiratory factor 1 isoform X2

    UniProtKB/TrEMBL
    Q8CAV3, Q99K73
    Related
    ENSMUSP00000065568.7, ENSMUST00000069808.13
    Conserved Domains (2) summary
    cd04867
    Location:450 → 525
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 283
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  4. XM_017321440.3 → XP_017176929.1  nuclear respiratory factor 1 isoform X1

    UniProtKB/TrEMBL
    Q8CAV3
    Conserved Domains (2) summary
    cd04867
    Location:462 → 537
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  5. XM_011241046.4 → XP_011239348.1  nuclear respiratory factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011239348.1

    UniProtKB/TrEMBL
    Q8CAV3
    Conserved Domains (2) summary
    cd04867
    Location:462 → 537
    TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
    pfam10491
    Location:87 → 295
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU00.2 GenPept UniProtKB/Swiss-Prot:Q9WU00

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