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Npr3 natriuretic peptide receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 18162, updated on 5-Mar-2024

Summary

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Official Symbol
Npr3provided by MGI
Official Full Name
natriuretic peptide receptor 3provided by MGI
Primary source
MGI:MGI:97373
See related
Ensembl:ENSMUSG00000022206 AllianceGenome:MGI:97373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lgj; EF-2; stri; ANP-C; NPR-C; ANPR-C
Summary
Predicted to enable several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart and pericardium; and lung. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 24.7), subcutaneous fat pad adult (RPKM 23.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Npr3 in Genome Data Viewer
Location:
15 A1; 15 5.83 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11839982..11907287, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11839896..11907837, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37999 Neighboring gene predicted gene, 41272 Neighboring gene predicted gene, 34501 Neighboring gene STARR-seq mESC enhancer starr_38001 Neighboring gene STARR-seq mESC enhancer starr_38002 Neighboring gene predicted gene 5144 Neighboring gene RIKEN cDNA 1700047G03 gene Neighboring gene predicted gene, 34618 Neighboring gene SEC13 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury. Harrington EO, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Oct 1. PMID 35943160, Free PMC Article
  2. Natriuretic peptide signaling is involved in the expression of oxidative metabolism-related and muscle fiber constitutive genes in the gastrocnemius muscle. Ishikawa K, et al. Mol Cell Endocrinol, 2019 Aug 20. PMID 31255729
  3. NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice. Jansen HJ, et al. Circ Arrhythm Electrophysiol, 2019 Jan. PMID 30636477
  4. Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation. Rahmutula D, et al. Cardiovasc Res, 2019 Feb 1. PMID 30239604
  5. Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart. Tang J, et al. Circ Res, 2018 Mar 30. PMID 29374073

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
    Title: Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
  2. NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
    Title: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice.
  3. NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-beta1/Smad pathways.
    Title: NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways.
  4. Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
    Title: Natriuretic peptide receptor-C mediates the inhibitory effect of atrial natriuretic peptide on neutrophil recruitment to the lung during acute lung injury.
  5. Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
    Title: Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice.
  6. Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
    Title: Oxygen and steroids affect the regulatory role of natriuretic peptide receptor-C on surfactant secretion by type II cells.
  7. Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
    Title: Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.
  8. Gene expression of proliferator-activated receptor delta and estrogen-related receptor alpha, which upregulate oxidative metabolism, was increased in the gastrocnemius muscle of NPR-C- mice, irrespective of diet.
    Title: Natriuretic peptide signaling is involved in the expression of oxidative metabolism-related and muscle fiber constitutive genes in the gastrocnemius muscle.
  9. Absence of natriuretic peptide clearance receptor attenuates TGF-beta1-induced selective atrial fibrosis and atrial fibrillation.
    Title: Absence of natriuretic peptide clearance receptor attenuates TGF-β1-induced selective atrial fibrosis and atrial fibrillation.
  10. NPRC plays a critical role in the progression of angiotensin II-mediated atrial fibrillation and atrial dysfunction.
    Title: NPR-C (Natriuretic Peptide Receptor-C) Modulates the Progression of Angiotensin II-Mediated Atrial Fibrillation and Atrial Remodeling in Mice.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables natriuretic peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoclast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pancreatic juice secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atrial natriuretic peptide receptor 3
Names
Nppc receptor
atrial natriuretic peptide clearance receptor
atrial natriuretic peptide receptor type C
longjohn
strigosus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039181.2 → NP_001034270.1  atrial natriuretic peptide receptor 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001034270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to variant a.
    Source sequence(s)
    AC134793
    Consensus CDS
    CCDS88736.1
    UniProtKB/TrEMBL
    Q7TMG7
    Related
    ENSMUSP00000154180.2, ENSMUST00000228603.2
    Conserved Domains (3) summary
    cd06386
    Location:49 → 440
    PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
    cd12841
    Location:466 → 501
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    pfam01094
    Location:66 → 419
    ANF_receptor; Receptor family ligand binding region

  2. NM_001286395.2 → NP_001273324.1  atrial natriuretic peptide receptor 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, uses an alternate in-frame splice site in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AC134793
    Consensus CDS
    CCDS88735.1
    UniProtKB/TrEMBL
    A0A2I3BPR9
    Related
    ENSMUSP00000153895.2, ENSMUST00000228489.2
    Conserved Domains (2) summary
    cl10011
    Location:1 → 187
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    cl25995
    Location:212 → 247
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  3. NM_001411434.1 → NP_001398363.1  atrial natriuretic peptide receptor 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC134793
    UniProtKB/TrEMBL
    A0A2I3BPR9

  4. NM_001411435.1 → NP_001398364.1  atrial natriuretic peptide receptor 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC134793

  5. NM_001411436.1 → NP_001398365.1  atrial natriuretic peptide receptor 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC134793

  6. NM_008728.3 → NP_032754.2  atrial natriuretic peptide receptor 3 isoform a precursor

    See identical proteins and their annotated locations for NP_032754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC134793
    Consensus CDS
    CCDS27386.1
    UniProtKB/Swiss-Prot
    G3X9E5, P70180, P97804, Q9R025, Q9R027, Q9R028
    Related
    ENSMUSP00000066737.4, ENSMUST00000066529.5
    Conserved Domains (3) summary
    cd06386
    Location:49 → 440
    PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
    cd12841
    Location:471 → 502
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
    pfam01094
    Location:66 → 419
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    11839982..11907287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248376.1 → XP_030104236.1  atrial natriuretic peptide receptor 3 isoform X1

    Conserved Domains (2) summary
    cl10011
    Location:1 → 187
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    cl25995
    Location:217 → 248
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

  2. XM_006520031.4 → XP_006520094.1  atrial natriuretic peptide receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006520094.1

    Conserved Domains (2) summary
    cl10011
    Location:1 → 187
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    cl25995
    Location:217 → 248
    TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70180.3 GenPept UniProtKB/Swiss-Prot:P70180

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