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Npdc1 neural proliferation, differentiation and control 1 [ Mus musculus (house mouse) ]

Gene ID: 18146, updated on 3-Apr-2024

Summary

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Official Symbol
Npdc1provided by MGI
Official Full Name
neural proliferation, differentiation and control 1provided by MGI
Primary source
MGI:MGI:1099802
See related
Ensembl:ENSMUSG00000015094 AllianceGenome:MGI:1099802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NPDC-1
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in axial skeleton; nervous system; neural retina; and thymus. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 116.4), whole brain E14.5 (RPKM 82.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Npdc1 in Genome Data Viewer
Location:
2 A3; 2 17.23 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25293067..25299504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25403050..25409494)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9505 Neighboring gene suppressor APC domain containing 2 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11704 Neighboring gene fucosyltransferase 7 Neighboring gene ATP-binding cassette, sub-family A member 2 Neighboring gene microRNA 3087

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proliferation and differentiation properties of bipotent glial progenitor cell lines immortalized with the adenovirus E1A gene. Galiana E, et al. J Neurosci Res, 1993 Oct 1. PMID 7903403
  2. miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. Gao H, et al. Cell Cycle, 2020 Jul. PMID 32544377, Free PMC Article
  3. Functional analysis of the NPDC-1 gene. Evrard C, et al. Gene, 2004 Dec 8. PMID 15563841
  4. Characterization and tissue expression of a novel human gene npdc1. Qu X, et al. Gene, 2001 Feb 7. PMID 11245976
  5. Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Galiana E, et al. Proc Natl Acad Sci U S A, 1995 Feb 28. PMID 7878019, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural proliferation differentiation and control protein 1
Names
neural proliferation differentiation control-1 protein
neural proliferation, differentiation and control gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420469.1 → NP_001407398.1  neural proliferation differentiation and control protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732557

  2. NM_008721.5 → NP_032747.2  neural proliferation differentiation and control protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032747.2

    Status: VALIDATED

    Source sequence(s)
    AL732557
    Consensus CDS
    CCDS15771.1
    UniProtKB/Swiss-Prot
    Q64322, Q99J69
    UniProtKB/TrEMBL
    Q925Q2
    Related
    ENSMUSP00000071387.6, ENSMUST00000071442.12
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 332
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25293067..25299504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497777.5 → XP_006497840.1  neural proliferation differentiation and control protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006497840.1

    UniProtKB/TrEMBL
    A2AJ23, Q8CFL4
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 249
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64322.2 GenPept UniProtKB/Swiss-Prot:Q64322

Gene LinkOut

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