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Nmt2 N-myristoyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 18108, updated on 5-Mar-2024

Summary

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Official Symbol
Nmt2provided by MGI
Official Full Name
N-myristoyltransferase 2provided by MGI
Primary source
MGI:MGI:1202298
See related
Ensembl:ENSMUSG00000026643 AllianceGenome:MGI:1202298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hNMT-2; A930001K02Rik
Summary
Predicted to enable glycylpeptide N-tetradecanoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation. Predicted to act upstream of or within N-terminal protein myristoylation. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm. Is expressed in early conceptus; embryo; liver; lung; and spinal cord. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 16.8), CNS E18 (RPKM 14.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 1.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3285249..3329914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3284212..3328877)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03510 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. Rampoldi F, et al. J Immunol, 2015 Nov 1. PMID 26423150
  2. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells. Rampoldi F, et al. J Leukoc Biol, 2017 Apr. PMID 28062573
  3. N-myristoyltransferase 1 is essential in early mouse development. Yang SH, et al. J Biol Chem, 2005 May 13. PMID 15753093
  4. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Ducker CE, et al. Mol Cancer Res, 2005 Aug. PMID 16123142, Free PMC Article
  5. The biology and enzymology of protein N-myristoylation. Farazi TA, et al. J Biol Chem, 2001 Oct 26. PMID 11527981

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation
    Title: Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptidyl-lysine N6-myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within N-terminal protein myristoylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycylpeptide N-tetradecanoyltransferase 2
Names
myristoyl-CoA:protein N-myristoyltransferase 2
peptide N-myristoyltransferase 2
type II N-myristoyltransferase
NP_001277297.1
NP_001277298.1
NP_001277299.1
NP_032734.1
XP_036015249.1
XP_036015250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290368.1 → NP_001277297.1  glycylpeptide N-tetradecanoyltransferase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK161490, AL732620, AL928883
    Conserved Domains (2) summary
    pfam01233
    Location:133 → 287
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:303 → 478
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  2. NM_001290369.1 → NP_001277298.1  glycylpeptide N-tetradecanoyltransferase 2 isoform c

    See identical proteins and their annotated locations for NP_001277298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS70972.1
    UniProtKB/TrEMBL
    F7APP3
    Related
    ENSMUSP00000089085.5, ENSMUST00000091504.5
    Conserved Domains (2) summary
    pfam01233
    Location:127 → 281
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:297 → 472
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  3. NM_001290370.1 → NP_001277299.1  glycylpeptide N-tetradecanoyltransferase 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS70971.1
    UniProtKB/TrEMBL
    A2AJH3
    Related
    ENSMUSP00000100054.4, ENSMUST00000102989.10
    Conserved Domains (2) summary
    pfam01233
    Location:140 → 294
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:310 → 485
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  4. NM_008708.2 → NP_032734.1  glycylpeptide N-tetradecanoyltransferase 2 isoform a

    See identical proteins and their annotated locations for NP_032734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK134521, AL732620, AL928883
    Consensus CDS
    CCDS15644.1
    UniProtKB/Swiss-Prot
    O70311
    UniProtKB/TrEMBL
    Q3THR4
    Related
    ENSMUSP00000080600.7, ENSMUST00000081932.13
    Conserved Domains (2) summary
    pfam01233
    Location:171 → 325
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:341 → 516
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3285249..3329914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159357.1 → XP_036015250.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    Conserved Domains (1) summary
    COG5092
    Location:22 → 389
    NMT1; N-myristoyl transferase [Lipid metabolism]

  2. XM_036159356.1 → XP_036015249.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    Conserved Domains (1) summary
    COG5092
    Location:55 → 422
    NMT1; N-myristoyl transferase [Lipid metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70311.1 GenPept UniProtKB/Swiss-Prot:O70311

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