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Nqo1 NAD(P)H dehydrogenase, quinone 1 [ Mus musculus (house mouse) ]

Gene ID: 18104, updated on 5-Mar-2024

Summary

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Official Symbol
Nqo1provided by MGI
Official Full Name
NAD(P)H dehydrogenase, quinone 1provided by MGI
Primary source
MGI:MGI:103187
See related
Ensembl:ENSMUSG00000003849 AllianceGenome:MGI:103187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dtd; Ox1; Qr1; Dia4; Nmo1; Ox-1; Nmo-1; Nmor1
Summary
Enables NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within negative regulation of catalytic activity and response to oxidative stress. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Predicted to be active in cytosol. Is expressed in heart; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 86.2), bladder adult (RPKM 36.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 54.08 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108114856..108139012, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107388225..107403205, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22599 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_22600 Neighboring gene nuclear factor of activated T cells 5 Neighboring gene STARR-positive B cell enhancer ABC_E9742 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene NIN1/RPN12 binding protein 1 homolog Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. Wang TX, et al. Life Sci Alliance, 2023 Jan. PMID 36319062, Free PMC Article
  2. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels. Nishida-Tamehiro K, et al. PLoS One, 2022. PMID 35905076, Free PMC Article
  3. NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy. Qiu D, et al. J Transl Med, 2022 Jan 28. PMID 35090502, Free PMC Article
  4. β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease. Flores-Soto ME, et al. Neurosci Lett, 2021 Jan 18. PMID 33271195
  5. The potential roles of NAD(P)H:quinone oxidoreductase 1 in the development of diabetic nephropathy and actin polymerization. Moon SJ, et al. Sci Rep, 2020 Oct 20. PMID 33082368, Free PMC Article

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
    Title: Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
  2. Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
    Title: Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
  3. Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway.
    Title: Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway.
  4. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels.
    Title: Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels.
  5. NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
    Title: NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
  6. Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance.
    Title: Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance.
  7. Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth.
    Title: Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth.
  8. A redox-mediated conformational change in NQO1 controls binding to microtubules and alpha-tubulin acetylation.
    Title: A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation.
  9. NQO1 regulates pharmaco-behavioral effects of d-amphetamine in striatal dopaminergic system in mice.
    Title: NQO1 regulates pharmaco-behavioral effects of d-amphetamine in striatal dopaminergic system in mice.
  10. beta-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease.
    Title: β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD(P)H dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NADH oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
  
involved_in response to L-glutamine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to amine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin E metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vitamin K metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vitamin K metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)H dehydrogenase [quinone] 1
Names
DT-diaphorase
NAD(P)H dehydrogenase (quinone)
NAD(P)H menadione oxidoreductase 1, dioxin inducible
NAD(P)H:quinone oxidoreductase 1
azoreductase
diaphorase 4 (NADH/NADPH)
menadione reductase
phylloquinone reductase
quinone reductase 1
NP_032732.3
XP_036009703.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008706.5 → NP_032732.3  NAD(P)H dehydrogenase [quinone] 1

    See identical proteins and their annotated locations for NP_032732.3

    Status: VALIDATED

    Source sequence(s)
    AA982077, AK075568
    Consensus CDS
    CCDS40465.1
    UniProtKB/Swiss-Prot
    Q64669
    UniProtKB/TrEMBL
    Q542Y0, Q99KL8
    Related
    ENSMUSP00000003947.9, ENSMUST00000003947.9
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    108114856..108139012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153810.1 → XP_036009703.1  NAD(P)H dehydrogenase [quinone] 1 isoform X1

    UniProtKB/Swiss-Prot
    Q64669
    UniProtKB/TrEMBL
    Q542Y0, Q99KL8
    Conserved Domains (1) summary
    pfam02525
    Location:5 → 212
    Flavodoxin_2; Flavodoxin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64669.3 GenPept UniProtKB/Swiss-Prot:Q64669

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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