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Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [ Mus musculus (house mouse) ]

Gene ID: 18036, updated on 5-Mar-2024

Summary

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Official Symbol
Nfkbibprovided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, betaprovided by MGI
Primary source
MGI:MGI:104752
See related
Ensembl:ENSMUSG00000030595 AllianceGenome:MGI:104752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IkB; IkBb; ikB-B; IKB-beta; IKappaBbeta; NF-kappa-BIB; I-kappa-B-beta; I(Kappa)B(beta)
Summary
This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in testis adult (RPKM 35.6), duodenum adult (RPKM 28.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B1; 7 16.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28457676..28466069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28758251..28766644, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene seryl-aminoacyl-tRNA synthetase 2 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene Ras and Rab interactor-like Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress. Wright CJ, et al. J Biol Chem, 2012 Feb 24. PMID 22223647, Free PMC Article
  2. A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. Biswas G, et al. J Biol Chem, 2008 May 2. PMID 18272519, Free PMC Article
  3. Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis. Clohisy JC, et al. J Immunol, 2003 Nov 15. PMID 14607962
  4. Cloning and characterization of the gene encoding mouse IkappaBbeta. Budde LM, et al. Gene, 2000 Apr 18. PMID 10773467
  5. Assignment of Nfkbib to murine chromosome bands 7A3-B3 by in situ hybridization. Klein BS, et al. Cytogenet Cell Genet, 1999. PMID 10449924

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFkappaB inhibitory protein IkappaBbeta to drive IL1alpha and IL1beta expression.
    Title: CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NFκB inhibitory protein IκBβ to drive IL1α and IL1β expression.
  2. IkappaBbeta has essential functions within the Rel-NFkappaB generation module, specifically for the RelA:RelA homodimer, which controls a subset of NFkappaB target genes.
    Title: IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.
  3. these results mechanistically link the innate immune response mediated by IkappaBbeta/NF-kappaB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
    Title: Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.
  4. Dengue virus protease interacts with both IkappaBalpha and IkappaBbeta cleaving them in a mouse hemorrhage model.
    Title: Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development.
  5. sustained NF-kappaB activity mediated by IkappaBbeta protects against hyperoxic lung injury through increased expression of antiapoptotic genes
    Title: IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury.
  6. Findings represent a necessary but not sufficient role of IkappaBbeta in preventing oxidant stress-induced cell death.
    Title: Nuclear factor-κB (NF-κB) inhibitory protein IκBβ determines apoptotic cell death following exposure to oxidative stress.
  7. IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
    Title: IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
  8. IkappaBbeta acts through p65:c-Rel dimers to maintain prolonged expression of TNF-alpha
    Title: IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.
  9. These results show that mitochondrial stress signaling uses an IkappaBbeta-initiated NFkappaB pathway that is distinct from the other known NFkappaB pathways.
    Title: A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.
  10. In vivo degradation rate constants were measured for NF-kappaB-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
    Title: A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor beta
Names
nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306222.1 → NP_001293151.1  NF-kappa-B inhibitor beta

    See identical proteins and their annotated locations for NP_001293151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC171210, AK010218, AK038631, BM899229
    Consensus CDS
    CCDS21054.1
    UniProtKB/Swiss-Prot
    Q564F1, Q60778, Q9D6L5
    UniProtKB/TrEMBL
    Q8VC27
    Related
    ENSMUSP00000083012.6, ENSMUST00000085851.12
    Conserved Domains (4) summary
    cd00204
    Location:202 → 298
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:211 → 298
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:58 → 113
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:206 → 237
    ANK; ANK repeat [structural motif]

  2. NM_010908.5 → NP_035038.2  NF-kappa-B inhibitor beta

    See identical proteins and their annotated locations for NP_035038.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC171210, AK038631
    Consensus CDS
    CCDS21054.1
    UniProtKB/Swiss-Prot
    Q564F1, Q60778, Q9D6L5
    UniProtKB/TrEMBL
    Q8VC27
    Related
    ENSMUSP00000032815.5, ENSMUST00000032815.11
    Conserved Domains (4) summary
    cd00204
    Location:202 → 298
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:211 → 298
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:58 → 113
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:206 → 237
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28457676..28466069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60778.2 GenPept UniProtKB/Swiss-Prot:Q60778

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