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Nfic nuclear factor I/C [ Mus musculus (house mouse) ]

Gene ID: 18029, updated on 11-Apr-2024

Summary

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Official Symbol
Nficprovided by MGI
Official Full Name
nuclear factor I/Cprovided by MGI
Primary source
MGI:MGI:109591
See related
Ensembl:ENSMUSG00000055053 AllianceGenome:MGI:109591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NF1-C; 1110019L22Rik; 1500041O16Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within odontogenesis of dentin-containing tooth. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and skeletal musculature. Orthologous to human NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 27.2), lung adult (RPKM 13.1) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81232025..81267753, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81396191..81431919, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 48551 Neighboring gene predicted gene, 48552 Neighboring gene small integral membrane protein 24 Neighboring gene predicted gene 16104 Neighboring gene microRNA 1191b Neighboring gene predicted gene, 53593 Neighboring gene predicted gene, 51811 Neighboring gene STARR-positive B cell enhancer ABC_E577 Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene nicalin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription. Jia P, et al. Tissue Cell, 2023 Apr. PMID 36669387
  2. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Huang W, et al. Cell Death Dis, 2021 Dec 20. PMID 34930914, Free PMC Article
  3. Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration. Edelmann S, et al. Liver Int, 2015 Apr. PMID 25293436
  4. Zinc balance is critical for NFI-C mediated regulation of odontoblast differentiation. Oh HJ, et al. J Cell Biochem, 2012 Mar. PMID 22228435
  5. Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development. Lee DS, et al. J Biol Chem, 2009 Jun 19. PMID 19386589, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
    Title: NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
  2. NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
    Title: NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
  3. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
    Title: Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
  4. Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
    Title: Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
  5. NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
    Title: NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
  6. the Runx2-Nfic-Osx pathway is one of the key factors that regulate ameloblast differentiation.
    Title: The Nfic-osterix pathway regulates ameloblast differentiation and enamel formation.
  7. An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation.
    Title: An Nfic-hedgehog signaling cascade regulates tooth root development.
  8. NFI-C acts as a regulator of the phased hepatocyte proliferation during liver regeneration.
    Title: Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.
  9. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs.
    Title: NFI-C regulates osteoblast differentiation via control of osterix expression.
  10. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-beta1 signaling in mouse odontoblasts.
    Title: Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear factor 1 C-type
Names
CCAAT-box-binding transcription factor
CTF
NF-I/C
NFI-C
TGGCA-binding protein
nuclear factor 1-C2
nuclear factor 1/C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008688.3 → NP_032714.1  nuclear factor 1 C-type isoform a

    See identical proteins and their annotated locations for NP_032714.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes a longer isoform (a).
    Source sequence(s)
    AC155937, AK087539, BY226699
    Consensus CDS
    CCDS24058.1
    UniProtKB/Swiss-Prot
    O09072, P70255, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3
    UniProtKB/TrEMBL
    A0A1Y7VK55
    Related
    ENSMUSP00000020461.9, ENSMUST00000020461.15
    Conserved Domains (3) summary
    pfam00859
    Location:217 → 424
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. NM_026756.2 → NP_081032.2  nuclear factor 1 C-type isoform b

    See identical proteins and their annotated locations for NP_081032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate penultimate exon, resulting in a novel 3' coding region and shorter 3' UTR, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC155937, AK147496, BY226699
    Consensus CDS
    CCDS35999.1
    UniProtKB/TrEMBL
    A0A1Y7VK55, Q3UHA6
    Related
    ENSMUSP00000100958.4, ENSMUST00000105321.10
    Conserved Domains (3) summary
    pfam00859
    Location:217 → 423
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:10 → 47
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 169
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81232025..81267753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244940.1 → XP_030100800.1  nuclear factor 1 C-type isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VK55
    Conserved Domains (3) summary
    pfam00859
    Location:208 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. XM_006513335.4 → XP_006513398.1  nuclear factor 1 C-type isoform X1

    See identical proteins and their annotated locations for XP_006513398.1

    UniProtKB/TrEMBL
    A0A1Y7VK55
    Related
    ENSMUSP00000113046.2, ENSMUST00000117966.2
    Conserved Domains (3) summary
    pfam00859
    Location:208 → 415
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 164
    MH1; N-terminal Mad Homology 1 (MH1) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70255.1 GenPept UniProtKB/Swiss-Prot:P70255

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