Nfe2l3 nuclear factor, erythroid derived 2, like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfe2l3provided by MGI
Official Full Name: nuclear factor, erythroid derived 2, like 3provided by MGI
Primary source: MGI:MGI:1339958
See related: Ensembl:ENSMUSG00000029832 AllianceGenome:MGI:1339958
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrf3
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; forelimb bud; gonad; and ureter. Orthologous to human NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 16.5), CNS E18 (RPKM 5.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 24.84 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (51409649..51435752)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (51432669..51458772)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice.
Title: Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic Transcription Factor in Obese Mice.
Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.
Title: Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment.
Nrf3-deficient keratinocytes exhibit stronger cell-cell and cell-matrix adhesion, which correlates with higher cell surface integrin levels and enhanced activation of focal adhesion kinase.
Title: Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion.
Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 and Pla2g7 are essential.
Title: Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells.
Contrary to wild-type mice, Nrf3-null animals are highly susceptible to B[a]P, exhibiting significantly increased mortality. Pathology analysis revealed a high incidence of T-cell lymphoblastic lymphoma in B[a]P-treated Nrf3(-/-) mice.
Title: Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma.
Demonstrate that Nrf3 has a crucial role in smooth muscle cell differentiation from embryonic stem cells.
Title: Crucial role of nrf3 in smooth muscle cell differentiation from stem cells.
data are presented suggesting that the NHB2 sequence in mouse Nrf3 may regulate the topology of the transcription factor within the ER membrane
Title: The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.
Data show that Nrf3 null mice develop normally with no obvious phenotypic differences compared to wild-type animals, that they are fertile, and that gross anatomy as well as behavior appear normal.
Title: Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear factor erythroid 2-related factor 3

Names: NF-E2-related factor 3; NFE2-related factor 3; nuclear factor erythroid 2-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010903.2 → NP_035033.1 nuclear factor erythroid 2-related factor 3

See identical proteins and their annotated locations for NP_035033.1

Status: VALIDATED

Source sequence(s)

AC154011, AK133935, AV237858, CJ045939

Consensus CDS

CCDS20134.1

UniProtKB/Swiss-Prot

Q9WTM4

UniProtKB/TrEMBL

Q3UUW2, Q3UZC1

Related

ENSMUSP00000005103.6, ENSMUST00000005103.12

Conserved Domains (1) summary

cd14720
Location:538 → 605

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain