Nfatc2ip nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfatc2ipprovided by MGI
Official Full Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting proteinprovided by MGI
Primary source: MGI:MGI:1329015
See related: Ensembl:ENSMUSG00000030722 AllianceGenome:MGI:1329015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NIP45; D7Ertd304e
Summary: Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early embryo; eye; genitourinary system; and limb. Orthologous to human NFATC2IP (nuclear factor of activated T cells 2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 15.5), thymus adult (RPKM 7.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (125982025..125995909, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126382853..126396796, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
Title: Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).
Under standard, non-stressful conditions, FLAG-mNip45 diffusely distributed in the nucleus.
Title: Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization.
results indicate that RANKL signaling down regulates NIP45 expression and that NIP45 is a negative regulator of osteoclast differentiation
Title: NIP45 negatively regulates RANK ligand induced osteoclast differentiation.
This finding highlights a possible role of the RENi proteins in the modulation of Ubc9-mediated poly-SUMO formation.
Title: Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.
NIP45 promotes robust cytokine expression in vivo, which is required for the efficient handling of parasites, acting as a molecular rheostat serving to amplify the type-2 immune response.
Title: NIP45 controls the magnitude of the type 2 T helper cell response.
Data report a role for arginine methylation of NIP45 in regulating cytokine gene transcription in the T helper lymphocyte.
Title: Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.
TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription.
Title: TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: NFATC2-interacting protein

Names: 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412712.1 → NP_001399641.1 NFATC2-interacting protein isoform 2

Status: VALIDATED

Source sequence(s)

AC125322
NM_001412713.1 → NP_001399642.1 NFATC2-interacting protein isoform 3

Status: VALIDATED

Source sequence(s)

AC125322
NM_010900.4 → NP_035030.2 NFATC2-interacting protein isoform 1

See identical proteins and their annotated locations for NP_035030.2

Status: VALIDATED

Source sequence(s)

AC125322

Consensus CDS

CCDS21827.1

UniProtKB/Swiss-Prot

O09130, Q8CDG2, Q9CVY5

Related

ENSMUSP00000075094.5, ENSMUST00000075671.5

Conserved Domains (2) summary

smart00213
Location:258 → 327

UBQ; Ubiquitin homologues

cl00155
Location:341 → 410

UBQ; Ubiquitin-like proteins