Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nedd8provided by MGI
Official Full Name: neural precursor cell expressed, developmentally down-regulated gene 8provided by MGI
Primary source: MGI:MGI:97301
See related: Ensembl:ENSMUSG00000010376 AllianceGenome:MGI:97301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rub1; NEDD-8
Summary: Predicted to enable protein tag and ubiquitin protein ligase binding activity. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 174.5), CNS E14 (RPKM 168.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55899720..55909337, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55662263..55671880, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We present here the first evidence that the neuroinflammatory mediator IL-1beta facilitates ubiquitin ligase parkin/NEDD8 interactions
Title: Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.
Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.
Title: Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Title: NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.
neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 is required for its interaction with TRAF6.
Title: Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury.
Our findings provide mechanistic evidence of the effects of IAP antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
Title: An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
a role of Nedd8 in regulating caspase-1 activation following inflammasome activation
Title: Nedd8 regulates inflammasome-dependent caspase-1 activation.
Nedd8 and its associated E2 carrier protein (Ubc12) and E3-SCF ligase play a key role in regulating the expression and activity of ENaC in alveolar pneumocytes.
Title: H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8.
a new regulatory mechanism of RCAN1 function
Title: Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin.
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
Title: c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.
The NEDD8 pathway appears to play an important role in CD4+ T-cell-mediated inflammatory responses
Title: Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein neddylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein neddylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein neddylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: NEDD8

Names: neddylin; neural precursor cell expressed developmentally down-regulated protein 8; ubiquitin-like protein Nedd8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008683.4 → NP_032709.1 NEDD8

See identical proteins and their annotated locations for NP_032709.1

Status: VALIDATED

Source sequence(s)

AI847056, AK146732

Consensus CDS

CCDS49498.1

UniProtKB/Swiss-Prot

P29595

UniProtKB/TrEMBL

Q3TY05, Q3UI46

Related

ENSMUSP00000010520.9, ENSMUST00000010520.10

Conserved Domains (1) summary

cd01806
Location:3 → 76

Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins