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Ncam2 neural cell adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 17968, updated on 11-Apr-2024

Summary

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Official Symbol
Ncam2provided by MGI
Official Full Name
neural cell adhesion molecule 2provided by MGI
Primary source
MGI:MGI:97282
See related
Ensembl:ENSMUSG00000022762 AllianceGenome:MGI:97282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ocam; RNCAM; Ncam-2
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cell adhesion. Located in axon. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 3.2), frontal lobe adult (RPKM 3.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ncam2 in Genome Data Viewer
Location:
16 C3.3; 16 45.89 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (80997501..81425549)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (81200697..81624290)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41327 Neighboring gene FK506 binding protein 1a, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_41328 Neighboring gene STARR-seq mESC enhancer starr_41329 Neighboring gene STARR-seq mESC enhancer starr_41331 Neighboring gene STARR-seq mESC enhancer starr_41333 Neighboring gene STARR-seq mESC enhancer starr_41334 Neighboring gene predicted gene, 49558 Neighboring gene cell division cycle 5-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization. Parcerisas A, et al. Int J Mol Sci, 2021 Jul 9. PMID 34299022, Free PMC Article
  2. Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation. Sheng L, et al. Cereb Cortex, 2019 Apr 1. PMID 29522129
  3. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. Sheng L, et al. J Neurosci, 2015 Jan 28. PMID 25632147, Free PMC Article
  4. Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli. Borisovska M, et al. J Physiol, 2011 Apr 15. PMID 21486802, Free PMC Article
  5. Identification of a novel neural cell adhesion molecule-related gene with a potential role in selective axonal projection. Alenius M, et al. J Biol Chem, 1997 Oct 17. PMID 9334170

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
    Title: Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
  2. Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
    Title: Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
  3. The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.
    Title: The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.
  4. NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
    Title: NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
  5. New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.
    Title: New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.
  6. Study demonstrates that an increase in NCAM2 levels results in increased instability of dendritic protrusions and reduced conversion of protrusions to dendritic spines in mouse cortical neurons.
    Title: Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.
  7. Abeta-dependent disruption of NCAM2 functions in Alzheimer's disease hippocampus contributes to synapse loss.
    Title: Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.
  8. These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling
    Title: OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor.
  9. This study identified the cell adhesion molecule NCAM2 as a new regulator of filopodial formation and neurite branching.
    Title: Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels.
  10. Two novel Mmatrix metallopeptidase 9 targets were identified: synaptic cell adhesion molecule-2 and collapsin response mediator protein-2
    Title: Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neural cell adhesion molecule 2
Names
N-CAM-2
R4B12 antigen
neural cell adhesion molecule RB-8
olfactory axon cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113208.1 → NP_001106679.1  neural cell adhesion molecule 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001106679.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AF016620, AW121550, BB663005, BC119027, BM933307
    Consensus CDS
    CCDS49888.1
    UniProtKB/Swiss-Prot
    O35136, O35962, Q0VF23
    Related
    ENSMUSP00000063468.4, ENSMUST00000067602.5
    Conserved Domains (7) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    smart00408
    Location:414 → 482
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:308 → 395
    IG_like; Immunoglobulin like
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:22 → 111
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    cl11960
    Location:300 → 397
    Ig; Immunoglobulin domain

  2. NM_010954.4 → NP_035084.1  neural cell adhesion molecule 2 isoform b precursor

    See identical proteins and their annotated locations for NP_035084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC123849, AW121550, BC119027
    Consensus CDS
    CCDS28281.1
    UniProtKB/Swiss-Prot
    O35136
    Related
    ENSMUSP00000049390.8, ENSMUST00000037785.14
    Conserved Domains (7) summary
    cd05866
    Location:21 → 112
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    smart00408
    Location:414 → 482
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:308 → 395
    IG_like; Immunoglobulin like
    cd00063
    Location:496 → 588
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:22 → 111
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:594 → 678
    fn3; Fibronectin type III domain
    cl11960
    Location:300 → 397
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    80997501..81425549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159816.1 → XP_036015709.1  neural cell adhesion molecule 2 isoform X2

    UniProtKB/TrEMBL
    Q3V1M4
    Conserved Domains (5) summary
    smart00408
    Location:128 → 189
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:300 → 305
    Ig; Ig strand A [structural motif]
    cd05866
    Location:21 → 113
    IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
    cd20970
    Location:209 → 298
    IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
    cl11960
    Location:300 → 348
    Ig; Immunoglobulin domain

  2. XM_036159815.1 → XP_036015708.1  neural cell adhesion molecule 2 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:285 → 377
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:383 → 467
    fn3; Fibronectin type III domain
    pfam13927
    Location:190 → 268
    Ig_3; Immunoglobulin domain
    cd00096
    Location:89 → 94
    Ig; Ig strand A [structural motif]
    cl11960
    Location:89 → 186
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35136.1 GenPept UniProtKB/Swiss-Prot:O35136

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