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Nap1l4 nucleosome assembly protein 1-like 4 [ Mus musculus (house mouse) ]

Gene ID: 17955, updated on 5-Mar-2024

Summary

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Official Symbol
Nap1l4provided by MGI
Official Full Name
nucleosome assembly protein 1-like 4provided by MGI
Primary source
MGI:MGI:1316687
See related
Ensembl:ENSMUSG00000059119 AllianceGenome:MGI:1316687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nap2; D7Wsu30e; 2810410H14Rik
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Involved in nucleosome assembly. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including extraembryonic component; liver; lung; placenta; and tongue. Orthologous to human NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 74.3), CNS E14 (RPKM 61.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.24 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143067316..143103698, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143513579..143549882, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 18 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene predicted gene, 23297 Neighboring gene STARR-positive B cell enhancer ABC_E1362 Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene microRNA 7064 Neighboring gene STARR-seq mESC enhancer starr_20532 Neighboring gene STARR-seq mESC enhancer starr_20533 Neighboring gene predicted gene 15580

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Familial hypertrophic cardiomyopathy: man, mouse and cat. Baty C, et al. QJM, 1998 Dec. PMID 10024943
  2. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation. Dominguez F, et al. J Virol, 2021 Jul 26. PMID 34076483, Free PMC Article
  3. Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7. Purbowasito W, et al. DNA Res, 2004 Dec 31. PMID 15871462
  4. Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7. Nicholson RH, et al. Genomics, 2000 Aug 15. PMID 10950922
  5. The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Ghasemzadeh M, et al. Blood, 2013 May 30. PMID 23550035, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
    Title: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.
  2. Leukocyte migration is initiated by homotypic adhesive interactions between platelets, leading to the development of an NAP-2 chemotactic gradient within the thrombus body that guides leukocytes to sites of vascular injury.
    Title: The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.
  3. Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4.
    Title: Interaction between nucleosome assembly protein 1-like family members.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleosome assembly protein 1-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285489.1 → NP_001272418.1  nucleosome assembly protein 1-like 4 isoform a

    See identical proteins and their annotated locations for NP_001272418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AJ002198, BC089018, BY073069
    Consensus CDS
    CCDS85479.1
    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Related
    ENSMUSP00000147130.2, ENSMUST00000208190.2
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  2. NM_001285490.1 → NP_001272419.1  nucleosome assembly protein 1-like 4 isoform a

    See identical proteins and their annotated locations for NP_001272419.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC068006, AJ002198, BC089018
    Consensus CDS
    CCDS85479.1
    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Related
    ENSMUSP00000146474.2, ENSMUST00000209098.2
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  3. NM_008672.3 → NP_032698.1  nucleosome assembly protein 1-like 4 isoform b

    See identical proteins and their annotated locations for NP_032698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AJ002198, BC089018, BQ746389, BY073069
    Consensus CDS
    CCDS40197.1
    UniProtKB/Swiss-Prot
    O88701, Q78ZA7
    UniProtKB/TrEMBL
    A2RSB1, Q8C1W9
    Related
    ENSMUSP00000072510.6, ENSMUST00000072727.7
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143067316..143103698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508507.4 → XP_006508570.1  nucleosome assembly protein 1-like 4 isoform X6

    Conserved Domains (1) summary
    pfam00956
    Location:67 → 293
    NAP; Nucleosome assembly protein (NAP)

  2. XM_030242206.2 → XP_030098066.1  nucleosome assembly protein 1-like 4 isoform X8

    Conserved Domains (1) summary
    pfam00956
    Location:67 → 293
    NAP; Nucleosome assembly protein (NAP)

  3. XM_006508506.4 → XP_006508569.1  nucleosome assembly protein 1-like 4 isoform X5

    UniProtKB/TrEMBL
    Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:67 → 303
    NAP; Nucleosome assembly protein (NAP)

  4. XM_030242205.2 → XP_030098065.1  nucleosome assembly protein 1-like 4 isoform X7

    Conserved Domains (1) summary
    pfam00956
    Location:67 → 303
    NAP; Nucleosome assembly protein (NAP)

  5. XM_036152762.1 → XP_036008655.1  nucleosome assembly protein 1-like 4 isoform X2

    UniProtKB/TrEMBL
    Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  6. XM_036152764.1 → XP_036008657.1  nucleosome assembly protein 1-like 4 isoform X4

    UniProtKB/TrEMBL
    Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  7. XM_030242203.2 → XP_030098063.1  nucleosome assembly protein 1-like 4 isoform X6

    Conserved Domains (1) summary
    pfam00956
    Location:67 → 293
    NAP; Nucleosome assembly protein (NAP)

  8. XM_036152759.1 → XP_036008652.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  9. XM_036152763.1 → XP_036008656.1  nucleosome assembly protein 1-like 4 isoform X3

    UniProtKB/Swiss-Prot
    O88701, Q78ZA7
    UniProtKB/TrEMBL
    A2RSB1, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  10. XM_030242200.2 → XP_030098060.1  nucleosome assembly protein 1-like 4 isoform X3

    UniProtKB/Swiss-Prot
    O88701, Q78ZA7
    UniProtKB/TrEMBL
    A2RSB1, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  11. XM_030242202.1 → XP_030098062.1  nucleosome assembly protein 1-like 4 isoform X3

    UniProtKB/Swiss-Prot
    O88701, Q78ZA7
    UniProtKB/TrEMBL
    A2RSB1, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  12. XM_030242204.1 → XP_030098064.1  nucleosome assembly protein 1-like 4 isoform X6

    Conserved Domains (1) summary
    pfam00956
    Location:67 → 293
    NAP; Nucleosome assembly protein (NAP)

  13. XM_006508504.4 → XP_006508567.1  nucleosome assembly protein 1-like 4 isoform X1

    See identical proteins and their annotated locations for XP_006508567.1

    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  14. XM_006508505.5 → XP_006508568.1  nucleosome assembly protein 1-like 4 isoform X1

    See identical proteins and their annotated locations for XP_006508568.1

    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  15. XM_036152761.1 → XP_036008654.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)

  16. XM_036152760.1 → XP_036008653.1  nucleosome assembly protein 1-like 4 isoform X1

    UniProtKB/TrEMBL
    B7ZNL2, Q8C1W9
    Conserved Domains (1) summary
    pfam00956
    Location:65 → 338
    NAP; Nucleosome assembly protein (NAP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78ZA7.1 GenPept UniProtKB/Swiss-Prot:Q78ZA7

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