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Myom1 myomesin 1 [ Mus musculus (house mouse) ]

Gene ID: 17929, updated on 5-Mar-2024

Summary

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Official Symbol
Myom1provided by MGI
Official Full Name
myomesin 1provided by MGI
Primary source
MGI:MGI:1341430
See related
Ensembl:ENSMUSG00000024049 AllianceGenome:MGI:1341430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D430047A17Rik
Summary
Enables protein homodimerization activity. Acts upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; respiratory system; and skeleton. Orthologous to human MYOM1 (myomesin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 44.7), bladder adult (RPKM 18.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Myom1 in Genome Data Viewer
Location:
17 E1.3; 17 41.87 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71326455..71433851)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71003332..71126856)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3214 Neighboring gene myosin, light chain 12A, regulatory, non-sarcomeric Neighboring gene predicted gene, 53974 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:71533967-71534150 Neighboring gene STARR-positive B cell enhancer ABC_E4223 Neighboring gene lipin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71564522-71564823 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71573946-71574247 Neighboring gene elastin microfibril interfacer 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skelemin association with αIIbβ3 integrin: a structural model. Gorbatyuk V, et al. Biochemistry, 2014 Nov 4. PMID 25224262, Free PMC Article
  2. Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells. Reddy KB, et al. J Biol Chem, 1998 Dec 25. PMID 9857037
  3. Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins. Price MG, et al. J Biol Chem, 1993 Oct 15. PMID 8408035
  4. Nuclear localization of Myomesin-1: possible functions. Reddy KB, et al. J Muscle Res Cell Motil, 2008. PMID 18521710
  5. M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression. Steiner F, et al. Genomics, 1999 Feb 15. PMID 10036188

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in M band ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myomesin-1
Names
myomesin family member 1
skelemin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083934.1 → NP_001077403.1  myomesin-1 isoform 2

    See identical proteins and their annotated locations for NP_001077403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC154187, AC154218, AC154717
    Consensus CDS
    CCDS50176.1
    UniProtKB/TrEMBL
    Z4YJF5
    Related
    ENSMUSP00000136266.2, ENSMUST00000179759.3
    Conserved Domains (3) summary
    smart00409
    Location:264 → 350
    IG; Immunoglobulin
    cd00063
    Location:618 → 711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:1456 → 1547
    Ig; Immunoglobulin domain

  2. NM_010867.2 → NP_034997.2  myomesin-1 isoform 1

    See identical proteins and their annotated locations for NP_034997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC154187, AC154218, AC154717, AJ012072, BY790868, CA460156
    Consensus CDS
    CCDS37685.1
    UniProtKB/Swiss-Prot
    Q546T8, Q62234, Q6PAC0
    UniProtKB/TrEMBL
    Z4YJF5
    Related
    ENSMUSP00000072945.6, ENSMUST00000073211.13
    Conserved Domains (3) summary
    smart00410
    Location:264 → 350
    IG_like; Immunoglobulin like
    cd00063
    Location:618 → 711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:1554 → 1645
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    71326455..71433851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523788.5 → XP_006523851.1  myomesin-1 isoform X3

    Conserved Domains (3) summary
    smart00409
    Location:264 → 350
    IG; Immunoglobulin
    cd00063
    Location:618 → 711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:397 → 464
    Ig; Immunoglobulin domain

  2. XM_006523787.5 → XP_006523850.1  myomesin-1 isoform X2

    Conserved Domains (3) summary
    smart00409
    Location:264 → 350
    IG; Immunoglobulin
    cd00063
    Location:618 → 711
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl11960
    Location:397 → 464
    Ig; Immunoglobulin domain

  3. XM_036160365.1 → XP_036016258.1  myomesin-1 isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:237 → 326
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:770 → 773
    Ig; Ig strand A [structural motif]
    cl11960
    Location:770 → 861
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62234.2 GenPept UniProtKB/Swiss-Prot:Q62234

Gene LinkOut

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