Myog myogenin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myogprovided by MGI
Official Full Name: myogeninprovided by MGI
Primary source: MGI:MGI:97276
See related: Ensembl:ENSMUSG00000026459 AllianceGenome:MGI:97276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: myo; MYF4; bHLHc3
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of cell differentiation; and regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to lithium ion; cellular response to tumor necrosis factor; and skeletal muscle fiber development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human MYOG (myogenin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 55.9), CNS E11.5 (RPKM 6.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.18 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134217742..134220286)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134290004..134292548)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice.
Title: Protective effects of hachimijiogan (HJG), a Japanese Kampo medicine, on cancer cachectic muscle wasting in mice.
Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes.
Title: Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes.
IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
Title: IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
Title: PUFA Treatment Affects C2C12 Myocyte Differentiation, Myogenesis Related Genes and Energy Metabolism.
Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation.
Title: Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation.
Myogenin is required for assembly of the transcription machinery on muscle genes during skeletal muscle differentiation.
Title: Myogenin is required for assembly of the transcription machinery on muscle genes during skeletal muscle differentiation.
USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors.
Title: USP7-dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors.
The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network.
Title: The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network.
Autophagy proteins were measured to understand the molecule mechanisms. We also inhibited hypoxic autophagy and examined the changes in myogenin expression, myotubes formation, and apoptosis.
Title: Effects of Cobalt Chloride, a Hypoxia-Mimetic Agent, on Autophagy and Atrophy in Skeletal C2C12 Myotubes.
The ELF-EMFs did not affect C2C12 myoblast viability or proliferation rate. Conversely, at ELF-EMF intensity in the mT range, the myogenic process was accelerated, through increased expression of MyoD, myogenin, and connexin 43
Title: Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts: Role of Gap-Junction-Mediated Intercellular Communication.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548385

PMC151607P2 (e-PCR)
- UniSTS:271152

UniSTS:463953 (e-PCR)
- UniSTS:463953

Myog (e-PCR), detects polymorphism
- UniSTS:463953

PMC133893P1 (e-PCR)
- UniSTS:270678

PMC207566P7 (e-PCR)
- UniSTS:271960

Myog (e-PCR), detects polymorphism
- UniSTS:143979

Myog (e-PCR), detects polymorphism
- UniSTS:143980

Myog (e-PCR), detects polymorphism
- UniSTS:143981

Myog (e-PCR), detects polymorphism
- UniSTS:463214

Myog (e-PCR), detects polymorphism
- UniSTS:143982

Myog (e-PCR), detects polymorphism
- UniSTS:143983

PMC133998P4 (e-PCR)
- UniSTS:270709

D0Nds1 (e-PCR), detects polymorphism
- UniSTS:141456

UniSTS:205458 (e-PCR)
- UniSTS:205458

Myog (e-PCR), detects polymorphism
- UniSTS:205458

Myog (e-PCR), detects polymorphism
- UniSTS:545965

Myog (e-PCR), detects polymorphism
- UniSTS:265671

D1Mit140 (e-PCR), detects polymorphism
- UniSTS:128477

UniSTS:234220 (e-PCR)
- UniSTS:234220

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IC Inferred by Curator more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	TAS Traceable Author Statement more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myotube differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to denervation involved in regulation of muscle adaptation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to electrical stimulus involved in regulation of muscle adaptation	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity involved in regulation of muscle adaptation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	TAS Traceable Author Statement more info	PubMed
involved_in striated muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myogenin

Names: MYOD1-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.