Myo7a myosin VIIA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo7aprovided by MGI
Official Full Name: myosin VIIAprovided by MGI
Primary source: MGI:MGI:104510
See related: Ensembl:ENSMUSG00000030761 AllianceGenome:MGI:104510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hdb; sh1; Myo7; sh-1; USH1B; polka; nmf371
Summary: Enables protein domain specific binding activity. Involved in cellular protein localization. Acts upstream of or within several processes, including animal organ morphogenesis; phagolysosome assembly; and pigment granule transport. Located in several cellular components, including melanosome; photoreceptor connecting cilium; and stereocilium base. Is active in stereocilium. Is expressed in central nervous system; liver; sensory organ; and small intestine epithelium. Used to study Usher syndrome type 1 and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 25.0), testis adult (RPKM 17.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.57 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (97700261..97768730, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (98051054..98119522, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.
Title: TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.
Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B.
Title: Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B.
Expression of MYOSIN VIIA in developing mouse cochleovestibular ganglion neurons.
Title: Expression of MYOSIN VIIA in developing mouse cochleovestibular ganglion neurons.
This study reveals an unexpected isoform diversity of MYO7A expression in the cochlea
Title: Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex.
ion pair behavior stabilizes single alpha-helices in proteins
Title: Dynamic ion pair behavior stabilizes single α-helices in proteins.
Many of the genes found in the genetic network, pathways, and gene ontology categories of Myo7a are related to either deafness or blindness in Usher syndrome mouse model.
Title: The genetic dissection of Myo7a gene expression in the retinas of BXD mice.
Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2.
Title: Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.
MYO7A and PDZD7 interact in tissue-culture cells, and co-localize to the ankle-link region of stereocilia in wild-type but not Myo7a mutant mice.
Title: PDZD7-MYO7A complex identified in enriched stereocilia membranes.
MYO7A binds to and impinges on CASPASE-8, revealing a new regulatory axis affecting RIPK1>CASPASE-8 signaling. Results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases.
Title: The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.
Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration
Title: FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (5)
Targeted (3) 1 citation
Chemically induced (ENU) (15) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Smh12 (e-PCR), detects polymorphism
- UniSTS:142696

Myo7a (e-PCR), detects polymorphism
- UniSTS:532116

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in equilibrioception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mechanoreceptor differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagolysosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigment granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigment granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of light stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info	PubMed
part_of myosin VII complex	ISO Inferred from Sequence Orthology more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
NOT located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
NOT located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in stereocilium	EXP Inferred from Experiment more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium base	IDA Inferred from Direct Assay more info	PubMed
NOT located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in upper tip-link density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-VIIa

Names: motor protein; myosin-VIIa; shaker 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256081.1 → NP_001243010.1 unconventional myosin-VIIa isoform 1

See identical proteins and their annotated locations for NP_001243010.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC115022, AC157792

Consensus CDS

CCDS57565.1

UniProtKB/Swiss-Prot

E9QLP7, P97479, Q5MJ57

UniProtKB/TrEMBL

A0A0U1RPX7

Related

ENSMUSP00000102745.2, ENSMUST00000107128.8

Conserved Domains (13) summary

smart00015
Location:766 → 787

IQ; Calmodulin-binding motif

cd11881
Location:1605 → 1669

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1747 → 1896

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:60 → 741

MYSc; Myosin. Large ATPases

smart00295
Location:1903 → 2115

B41; Band 4.1 homologues

cd13198
Location:1468 → 1604

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2111 → 2206

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1363 → 1463

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:79 → 729

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:2013 → 2115

FERM_M; FERM central domain

pfam05672
Location:857 → 935

MAP7; MAP7 (E-MAP-115) family

pfam09379
Location:1262 → 1301

FERM_N; FERM N-terminal domain

pfam10153
Location:851 → 933

DUF2361; uncharacterized conserved protein (DUF2361)
NM_001256082.1 → NP_001243011.1 unconventional myosin-VIIa isoform 3

See identical proteins and their annotated locations for NP_001243011.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.

Source sequence(s)

AC115022, AC157792, AY821854

Consensus CDS

CCDS57564.1

UniProtKB/TrEMBL

A0A0U1RPX7, Q5MJ56

Related

ENSMUSP00000102739.2, ENSMUST00000107122.8

Conserved Domains (11) summary

PTZ00121
Location:798 → 970

PTZ00121; MAEBL; Provisional

smart00015
Location:761 → 782

IQ; Calmodulin-binding motif

cd11881
Location:1562 → 1626

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1704 → 1853

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1860 → 2072

B41; Band 4.1 homologues

cd13198
Location:1463 → 1561

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2068 → 2163

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 724

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1252 → 1350

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1858 → 1955

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:852 → 930

MAP7; MAP7 (E-MAP-115) family
NM_001256083.1 → NP_001243012.1 unconventional myosin-VIIa isoform 4

See identical proteins and their annotated locations for NP_001243012.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.

Source sequence(s)

AC115022, AC157792, AY821853

Consensus CDS

CCDS57563.1

UniProtKB/TrEMBL

A0A0R4J113, A0A0U1RPX7

Related

ENSMUSP00000082046.5, ENSMUST00000084979.11

Conserved Domains (11) summary

PTZ00121
Location:792 → 964

PTZ00121; MAEBL; Provisional

smart00015
Location:755 → 776

IQ; Calmodulin-binding motif

cd11881
Location:1556 → 1620

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1698 → 1847

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1854 → 2066

B41; Band 4.1 homologues

cd13198
Location:1457 → 1555

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2062 → 2157

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 718

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1246 → 1344

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1852 → 1949

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:846 → 924

MAP7; MAP7 (E-MAP-115) family
NM_008663.2 → NP_032689.2 unconventional myosin-VIIa isoform 2

See identical proteins and their annotated locations for NP_032689.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AC115022, AC157792, AY821853

Consensus CDS

CCDS40026.1

UniProtKB/TrEMBL

A0A0U1RPX7

Related

ENSMUSP00000102744.2, ENSMUST00000107127.8

Conserved Domains (13) summary

smart00015
Location:766 → 787

IQ; Calmodulin-binding motif

cd11881
Location:1567 → 1631

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1709 → 1858

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:60 → 741

MYSc; Myosin. Large ATPases

smart00295
Location:1865 → 2077

B41; Band 4.1 homologues

cd13198
Location:1468 → 1566

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2073 → 2168

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd14473
Location:1363 → 1463

FERM_B-lobe; FERM domain B-lobe

cd01381
Location:79 → 729

MYSc_Myo7; class VII myosin, motor domain

pfam00373
Location:1975 → 2077

FERM_M; FERM central domain

pfam05672
Location:857 → 935

MAP7; MAP7 (E-MAP-115) family

pfam09379
Location:1262 → 1301

FERM_N; FERM N-terminal domain

pfam10153
Location:851 → 933

DUF2361; uncharacterized conserved protein (DUF2361)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

97700261..97768730 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507427.5 → XP_006507490.1 unconventional myosin-VIIa isoform X5

UniProtKB/TrEMBL

A0A0U1RPX7

Conserved Domains (11) summary

PTZ00121
Location:809 → 981

PTZ00121; MAEBL; Provisional

smart00015
Location:772 → 793

IQ; Calmodulin-binding motif

cd11881
Location:1611 → 1675

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1753 → 1902

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1909 → 2121

B41; Band 4.1 homologues

cd13198
Location:1474 → 1610

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2117 → 2212

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:79 → 735

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1263 → 1361

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1907 → 2004

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:863 → 941

MAP7; MAP7 (E-MAP-115) family
XM_011241688.4 → XP_011239990.1 unconventional myosin-VIIa isoform X1

UniProtKB/TrEMBL

A0A0U1RPX7

Conserved Domains (11) summary

PTZ00121
Location:838 → 1010

PTZ00121; MAEBL; Provisional

smart00015
Location:801 → 822

IQ; Calmodulin-binding motif

cd11881
Location:1640 → 1704

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1782 → 1931

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1938 → 2150

B41; Band 4.1 homologues

cd13198
Location:1503 → 1639

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2146 → 2241

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:108 → 764

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1292 → 1390

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1936 → 2033

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:892 → 970

MAP7; MAP7 (E-MAP-115) family
XM_011241691.3 → XP_011239993.1 unconventional myosin-VIIa isoform X4

See identical proteins and their annotated locations for XP_011239993.1

UniProtKB/TrEMBL

A0A0R4J113, A0A0U1RPX7

Related

ENSMUSP00000146165.2, ENSMUST00000205746.2

Conserved Domains (11) summary

PTZ00121
Location:792 → 964

PTZ00121; MAEBL; Provisional

smart00015
Location:755 → 776

IQ; Calmodulin-binding motif

cd11881
Location:1556 → 1620

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1698 → 1847

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1854 → 2066

B41; Band 4.1 homologues

cd13198
Location:1457 → 1555

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2062 → 2157

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 718

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1246 → 1344

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1852 → 1949

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:846 → 924

MAP7; MAP7 (E-MAP-115) family
XM_011241689.3 → XP_011239991.1 unconventional myosin-VIIa isoform X2

UniProtKB/TrEMBL

A0A0U1RPX7

Conserved Domains (11) summary

PTZ00121
Location:792 → 964

PTZ00121; MAEBL; Provisional

smart00015
Location:755 → 776

IQ; Calmodulin-binding motif

cd11881
Location:1594 → 1658

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1736 → 1885

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1892 → 2104

B41; Band 4.1 homologues

cd13198
Location:1457 → 1593

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2100 → 2195

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 718

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1246 → 1344

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1890 → 1987

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:846 → 924

MAP7; MAP7 (E-MAP-115) family
XM_011241690.3 → XP_011239992.1 unconventional myosin-VIIa isoform X3

See identical proteins and their annotated locations for XP_011239992.1

UniProtKB/TrEMBL

A0A0U1RPX7, Q5MJ56

Conserved Domains (11) summary

PTZ00121
Location:798 → 970

PTZ00121; MAEBL; Provisional

smart00015
Location:761 → 782

IQ; Calmodulin-binding motif

cd11881
Location:1562 → 1626

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1704 → 1853

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1860 → 2072

B41; Band 4.1 homologues

cd13198
Location:1463 → 1561

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2068 → 2163

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:68 → 724

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1252 → 1350

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1858 → 1955

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:852 → 930

MAP7; MAP7 (E-MAP-115) family
XM_006507429.4 → XP_006507492.1 unconventional myosin-VIIa isoform X7

UniProtKB/TrEMBL

A0A0U1RPX7

Conserved Domains (11) summary

PTZ00121
Location:745 → 917

PTZ00121; MAEBL; Provisional

smart00015
Location:708 → 729

IQ; Calmodulin-binding motif

cd11881
Location:1547 → 1611

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1689 → 1838

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1845 → 2057

B41; Band 4.1 homologues

cd13198
Location:1410 → 1546

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2053 → 2148

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:21 → 671

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1199 → 1297

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1843 → 1940

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:799 → 877

MAP7; MAP7 (E-MAP-115) family
XM_006507428.4 → XP_006507491.1 unconventional myosin-VIIa isoform X6

UniProtKB/TrEMBL

A0A0U1RPX7

Conserved Domains (11) summary

PTZ00121
Location:751 → 923

PTZ00121; MAEBL; Provisional

smart00015
Location:714 → 735

IQ; Calmodulin-binding motif

cd11881
Location:1553 → 1617

SH3_MYO7A; Src Homology 3 domain of Myosin VIIa and similar proteins

smart00139
Location:1695 → 1844

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1851 → 2063

B41; Band 4.1 homologues

cd13198
Location:1416 → 1552

FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)

cd13199
Location:2059 → 2154

FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)

cd01381
Location:21 → 677

MYSc_Myo7; class VII myosin, motor domain

cd17092
Location:1205 → 1303

FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

cd17093
Location:1849 → 1946

FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins

pfam05672
Location:805 → 883

MAP7; MAP7 (E-MAP-115) family