Myo6 myosin VI [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo6provided by MGI
Official Full Name: myosin VIprovided by MGI
Primary source: MGI:MGI:104785
See related: Ensembl:ENSMUSG00000033577 AllianceGenome:MGI:104785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sv; Tlc; rsv; Myo6<rsv>
Summary: Predicted to enable actin filament binding activity; identical protein binding activity; and microfilament motor activity. Involved in postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including cellular response to electrical stimulus; inner ear development; and nervous system development. Located in several cellular components, including brush border; cochlear hair cell ribbon synapse; and glutamatergic synapse. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic actin cytoskeleton; and postsynaptic density. Is expressed in ear. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 13.1), placenta adult (RPKM 10.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E1; 9 43.98 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (80072262..80219011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (80164976..80311729)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo6 mediates osteoclast function and is essential for joint damage in collagen-induced arthritis.
Title: Myo6 mediates osteoclast function and is essential for joint damage in collagen-induced arthritis.
Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.
Title: Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region.
Title: GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region.
Myosin VI Haploinsufficiency Reduced Hearing Ability in Mice.
Title: Myosin VI Haploinsufficiency Reduced Hearing Ability in Mice.
Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesisdagger.
Title: Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†.
Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesisdaggerdouble dagger.
Title: Myosin VI maintains the actin-dependent organization of the tubulobulbar complexes required for endocytosis during mouse spermiogenesis†‡.
Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion.
Title: Formation of Aberrant Myotubes by Myoblasts Lacking Myosin VI Is Associated with Alterations in the Cytoskeleton Organization, Myoblast Adhesion and Fusion.
Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Title: Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Loss of MYO6 results in an accumulation of mitophagosomes and an increase in mitochondrial mass.
Title: Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
Title: MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (5) 1 citation
Chemically induced (ENU) (8) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048109 (e-PCR)
- UniSTS:109863

U49739 (e-PCR)
- UniSTS:125761

Myo6 (e-PCR), detects polymorphism
- UniSTS:143970

Myo6 (e-PCR), detects polymorphism
- UniSTS:143971

Myo6 (e-PCR), detects polymorphism
- UniSTS:143972

Myo6 (e-PCR), detects polymorphism
- UniSTS:143973

Myo6 (e-PCR), detects polymorphism
- UniSTS:143974

PMC124268P1 (e-PCR)
- UniSTS:270458

RH118329 (e-PCR)
- UniSTS:124105

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to electrical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear auditory receptor cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
colocalizes_with clathrin-coated endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
is_active_in cochlear hair cell ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info	PubMed
located_in vesicle membrane	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: unconventional myosin-VI

Names: Snell's waltzer; protein twist; tailchaser; unconventional myosin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039546.3 → NP_001034635.2 unconventional myosin-VI isoform 3

Status: VALIDATED

Source sequence(s)

AC120388, AC159738

Consensus CDS

CCDS23368.1

UniProtKB/Swiss-Prot

E9Q3L1, Q64331

UniProtKB/TrEMBL

B2RWR8

Related

ENSMUSP00000036181.9, ENSMUST00000035889.15

Conserved Domains (3) summary

smart00242
Location:52 → 771

MYSc; Myosin. Large ATPases

cd01382
Location:71 → 759

MYSc_Myo6; class VI myosin, motor domain

pfam16521
Location:1145 → 1235

Myosin-VI_CBD; Myosin VI cargo binding domain
NM_001408252.1 → NP_001395181.1 unconventional myosin-VI isoform 1

Status: VALIDATED

Source sequence(s)

AC120388, AC159738

UniProtKB/TrEMBL

V9GX76

Related

ENSMUSP00000139019.2, ENSMUST00000184480.8
NM_001408253.1 → NP_001395182.1 unconventional myosin-VI isoform 2

Status: VALIDATED

Source sequence(s)

AC120388, AC159738

Related

ENSMUSP00000075501.4, ENSMUST00000076140.4
NM_001408255.1 → NP_001395184.1 unconventional myosin-VI isoform 4

Status: VALIDATED

Source sequence(s)

AC120388, AC159738

UniProtKB/TrEMBL

E9Q175

Related

ENSMUSP00000108891.2, ENSMUST00000113266.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

80072262..80219011

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510836.3 → XP_006510899.1 unconventional myosin-VI isoform X2

UniProtKB/TrEMBL

E9Q174, V9GXM4

Conserved Domains (3) summary

TIGR04211
Location:845 → 928

SH3_and_anchor; SH3 domain protein

cd01382
Location:71 → 759

MYSc_Myo6; class VI myosin, motor domain

pfam16521
Location:1168 → 1258

Myosin-VI_CBD; Myosin VI cargo binding domain
XM_036154672.1 → XP_036010565.1 unconventional myosin-VI isoform X3

UniProtKB/TrEMBL

E9Q174
XM_030244104.2 → XP_030099964.1 unconventional myosin-VI isoform X4

UniProtKB/TrEMBL

E9PVU0

Conserved Domains (3) summary

TIGR04211
Location:845 → 928

SH3_and_anchor; SH3 domain protein

cd01382
Location:71 → 759

MYSc_Myo6; class VI myosin, motor domain

pfam16521
Location:1155 → 1245

Myosin-VI_CBD; Myosin VI cargo binding domain

RNA

XR_004935336.1 RNA Sequence
XR_004935335.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_008662.1: Suppressed sequence

Description

NM_008662.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.