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snap-1 Alpha-soluble NSF attachment protein;C2H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179193, updated on 5-May-2024

Summary

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Gene symbol
snap-1
Gene description
Alpha-soluble NSF attachment protein;C2H2-type domain-containing protein
Primary source
WormBase:WBGene00017016
Locus tag
CELE_D1014.3
See related
AllianceGenome:WB:WBGene00017016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable soluble NSF attachment protein activity and syntaxin binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be part of SNARE complex. Is expressed in nervous system and reproductive system. Orthologous to human NAPA (NSF attachment protein alpha) and NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (8130611..8133329)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene REST corepressor spr-1 Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Rathore SS, et al. Proc Natl Acad Sci U S A, 2010 Dec 28. PMID 21139055, Free PMC Article
  2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  3. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the syntaxin N-peptide is an initiation factor for the assembly of the SNARE-SM membrane fusion complex.
    Title: Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in SNARE complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Alpha-soluble NSF attachment protein;C2H2-type domain-containing protein
NP_001380251.1
  • Confirmed by transcript evidence
NP_505099.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8130611..8133329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392555.1 → NP_001380251.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WXT8
    Conserved Domains (1) summary
    cl24038
    Location:7 → 45
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  2. NM_072698.7 → NP_505099.2  Alpha-soluble NSF attachment protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505099.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18921
    Conserved Domains (2) summary
    cd15832
    Location:7 → 286
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    pfam14938
    Location:7 → 287
    SNAP; Soluble NSF attachment protein, SNAP
Nucleotide Protein
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