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Mylpf myosin light chain, phosphorylatable, fast skeletal muscle [ Mus musculus (house mouse) ]

Gene ID: 17907, updated on 11-Apr-2024

Summary

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Official Symbol
Mylpfprovided by MGI
Official Full Name
myosin light chain, phosphorylatable, fast skeletal muscleprovided by MGI
Primary source
MGI:MGI:97273
See related
Ensembl:ENSMUSG00000030672 AllianceGenome:MGI:97273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlc2; MLC-2; Myl11; 2410014J02Rik
Summary
A structural constituent of muscle. Involved in skeletal muscle tissue development. Predicted to be part of myosin complex. Is expressed in several structures, including diaphragm; embryo mesenchyme; eye; limb; and musculature. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C. Orthologous to human MYLPF (myosin light chain, phosphorylatable, fast skeletal muscle). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 230.4), limb E14.5 (RPKM 172.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Mylpf in Genome Data Viewer
Location:
7 F3; 7 69.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126808071..126813459)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127208848..127214288)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The fast skeletal muscle myosin light chain is differentially expressed in smooth muscle cells of OVA-challenged mouse trachea. Kim HY, et al. Mol Cells, 2008 Feb 29. PMID 18319617
  2. Construction of recombinant plasmids containing rat muscle actin and myosin light chain DNA sequences. Katcoff D, et al. Proc Natl Acad Sci U S A, 1980 Feb. PMID 6928693, Free PMC Article
  3. MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Bajaj G, et al. Biochem Biophys Res Commun, 2010 Jul 16. PMID 20510202, Free PMC Article
  4. Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development. Wang Y, et al. FASEB J, 2007 Jul. PMID 17356007
  5. Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. Kazuki Y, et al. Biochem Biophys Res Commun, 2004 Apr 30. PMID 15063784

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicated that sine oculis homeobox 1 (Six1) overexpression could significantly promote the expression of fast-type muscle genes Atp2a1, Srl, and Mylpf.
    Title: Overexpression of Six1 gene suppresses proliferation and enhances expression of fast-type muscle genes in C2C12 myoblasts.
  2. Data suggest that the overexpression of fast skeletal muscle myosin light chain in murine asthma may be associated with the changes of bronchial smooth muscle.
    Title: The fast skeletal muscle myosin light chain is differentially expressed in smooth muscle cells of OVA-challenged mouse trachea.
  3. Therefore, we suggest that Chr 21 gene(s) distal from the ETS2 locus reduce mouse mlc2a and PEBP expression in DS model mice and DS.
    Title: Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.
  4. RLC-f is necessary for skeletal muscle formation. The lack of skeletal muscle formation observed in RLC-f null mice indicates the total dependence of skeletal muscle development on the presence of RLC-f during embryogenesis.
    Title: Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myosin regulatory light chain 11
Names
MLC2F
fast skeletal myosin light chain 2
myosin light chain 11
myosin light chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347655.1 → NP_001334584.1  myosin regulatory light chain 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS85420.1
    UniProtKB/TrEMBL
    A0A0U1RP93
    Related
    ENSMUSP00000145886.2, ENSMUST00000206772.2
    Conserved Domains (1) summary
    COG5126
    Location:1 → 134
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_016754.5 → NP_058034.1  myosin regulatory light chain 11 isoform 1

    See identical proteins and their annotated locations for NP_058034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122537
    Consensus CDS
    CCDS40140.1
    UniProtKB/Swiss-Prot
    P97457
    UniProtKB/TrEMBL
    Q545G1
    Related
    ENSMUSP00000032910.7, ENSMUST00000032910.13
    Conserved Domains (1) summary
    COG5126
    Location:15 → 154
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126808071..126813459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97457.3 GenPept UniProtKB/Swiss-Prot:P97457

Gene LinkOut

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