U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow [ Mus musculus (house mouse) ]

Gene ID: 17906, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Myl2provided by MGI
Official Full Name
myosin, light polypeptide 2, regulatory, cardiac, slowprovided by MGI
Primary source
MGI:MGI:97272
See related
Ensembl:ENSMUSG00000013936 AllianceGenome:MGI:97272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MLC-2; Mlc2v; Mylpc; MLC-2v; Gm32672; MLC-2s/v
Summary
Predicted to enable actin monomer binding activity and calcium ion binding activity. Involved in heart development and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including cardiac muscle contraction; heart development; and muscle cell fate specification. Located in myofibril. Is expressed in several structures, including diaphragm; embryo mesoderm; eye; heart; and triceps surae muscle. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward heart adult (RPKM 1539.2) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5; 5 F
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122230787..122251536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122092724..122113473)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52785 Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC118568726 Neighboring gene predicted gene, 52786 Neighboring gene VISTA enhancer mm77 Neighboring gene STARR-seq mESC enhancer starr_14271 Neighboring gene STARR-positive B cell enhancer ABC_E3613 Neighboring gene coiled-coil domain containing 63 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595403-122595586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122595588-122595697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122634438-122634667 Neighboring gene STARR-seq mESC enhancer starr_14277 Neighboring gene protein phosphatase 1 catalytic subunit gamma Neighboring gene STARR-positive B cell enhancer ABC_E9650 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:122685188-122685492 Neighboring gene hydrogen voltage-gated channel 1 Neighboring gene tectonic family member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin. Rasicci DV, et al. J Gen Physiol, 2021 Jul 5. PMID 33891674, Free PMC Article
  2. Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca(2+) sensitivity. Zhang J, et al. FEBS J, 2021 Aug. PMID 33548158, Free PMC Article
  3. Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain. Huang W, et al. Arch Biochem Biophys, 2016 Jul 1. PMID 26906074, Free PMC Article
  4. RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis. Duan X, et al. Cell Cycle, 2016. PMID 26701676, Free PMC Article
  5. Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Tarigopula M, et al. Cardiovasc Res, 2015 Jul 15. PMID 26045475, Free PMC Article

See all (386) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2.
    Title: FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2.
  2. Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons.
    Title: Brain-derived neurotrophic factor regulates LYN kinase-mediated myosin light chain kinase activation to modulate nonmuscle myosin II activity in hippocampal neurons.
  3. Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin.
    Title: Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin.
  4. Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca(2+) sensitivity.
    Title: Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca(2+) sensitivity.
  5. Cardiac MLC2 kinase is localized to the Z-disc and interacts with alpha-actinin2.
    Title: Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2.
  6. Myosin II-deficient necrotic cells are impaired in their ability to stimulate DNGR-1 or to serve as substrates for Conventional type 1 dendritic cells cross-presentation to CD8(+) T cells.
    Title: Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens.
  7. transgenic mouse models of hypertrophic cardiomyopathy may be caused by mutations in myosin regulatory light chain
    Title: Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.
  8. MLC2 phosphorylation regulates actin-based cytokinesis in mouse oocytes, and this regulation may be mediated via a RhoA-MLC2-actin pathway.
    Title: RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis.
  9. Treatment of mice with an AT1R biased ligand, acting via beta-arrestin signalling, is able to induce an increase in cardiac contractility associated with an increase in ventricular myosin light chain-2 phosphorylation
    Title: Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.
  10. Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
    Title: Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cardiac muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in muscle cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of the force of heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cardiac myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in contractile muscle fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Names
myosin light chain 2v
myosin light chain, phosphorylatable, cardiac ventricles

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384326.1 → NP_001371255.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140353
    UniProtKB/Swiss-Prot
    P51667, Q6P8P4, Q9QVP3
    UniProtKB/TrEMBL
    E9Q8Y0
    Related
    ENSMUSP00000107380.2, ENSMUST00000111751.8
    Conserved Domains (1) summary
    COG5126
    Location:14 → 163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  2. NM_001384327.1 → NP_001371256.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. NM_001384328.1 → NP_001371257.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. NM_001384329.1 → NP_001371258.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. NM_001384330.1 → NP_001371259.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  6. NM_001384331.1 → NP_001371260.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140353
    Conserved Domains (1) summary
    COG5126
    Location:1 → 144
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  7. NM_010861.4 → NP_034991.3  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform 1

    See identical proteins and their annotated locations for NP_034991.3

    Status: VALIDATED

    Source sequence(s)
    AC140353, AK002367, BX529018
    Consensus CDS
    CCDS39252.1
    UniProtKB/Swiss-Prot
    P51667, Q6P8P4, Q9QVP3
    UniProtKB/TrEMBL
    E9Q8Y0
    Related
    ENSMUSP00000014080.7, ENSMUST00000014080.13
    Conserved Domains (1) summary
    COG5126
    Location:14 → 163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122230787..122251536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51667.3 GenPept UniProtKB/Swiss-Prot:P51667

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous