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Myh8 myosin, heavy polypeptide 8, skeletal muscle, perinatal [ Mus musculus (house mouse) ]

Gene ID: 17885, updated on 11-Apr-2024

Summary

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Official Symbol
Myh8provided by MGI
Official Full Name
myosin, heavy polypeptide 8, skeletal muscle, perinatalprovided by MGI
Primary source
MGI:MGI:1339712
See related
Ensembl:ENSMUSG00000055775 AllianceGenome:MGI:1339712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MHCp; Myhsp; Myhs-p; MyHC-pn; 4832426G23Rik
Summary
This gene encodes a myosin heavy chain. The encoded protein forms a hexamer with two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. This gene is located in a cluster of related genes on chromosome 11. [provided by RefSeq, Jun 2013]
Expression
Biased expression in limb E14.5 (RPKM 10.6), lung adult (RPKM 9.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 40.59 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67167950..67199460)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67277124..67308634)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG) Neighboring gene STARR-seq mESC enhancer starr_29799 Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene predicted gene, 40029 Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 31459

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression. Xing Y, et al. J Am Heart Assoc, 2023 Apr 4. PMID 36942752, Free PMC Article
  2. Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line. Cox RD, et al. Dev Biol, 1991 Jan. PMID 1985022
  3. Calpain-6 deficiency promotes skeletal muscle development and regeneration. Tonami K, et al. PLoS Genet, 2013. PMID 23935533, Free PMC Article
  4. Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development. Usami A, et al. Anat Histol Embryol, 2003 Aug. PMID 12919077
  5. Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle. Weydert A, et al. J Biol Chem, 1983 Nov 25. PMID 6196357

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
    Title: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to Govern Hypoxia-Inducible Factor-1α Expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4211

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-8
Names
Beta-MHC antisense
myHC-perinatal
myosin heavy chain 8
myosin heavy chain, skeletal muscle, perinatal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177369.3 → NP_796343.2  myosin-8

    See identical proteins and their annotated locations for NP_796343.2

    Status: REVIEWED

    Source sequence(s)
    AL596129
    Consensus CDS
    CCDS24857.1
    UniProtKB/Swiss-Prot
    P13542, Q5SX36
    UniProtKB/TrEMBL
    B2RWW8
    Related
    ENSMUSP00000019625.6, ENSMUST00000019625.12
    Conserved Domains (6) summary
    cl22853
    Location:102 → 769
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:90 → 769
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:849 → 1926
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:38 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam06273
    Location:1042 → 1099
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    cl19764
    Location:1375 → 1550
    COG6; Conserved oligomeric complex COG6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67167950..67199460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156398.1 → XP_036012291.1  myosin-8 isoform X1

    UniProtKB/TrEMBL
    B2RWW8
    Conserved Domains (3) summary
    pfam01576
    Location:849 → 1955
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:37 → 75
    Myosin_N; Myosin N-terminal SH3-like domain
    cl22853
    Location:102 → 769
    Motor_domain; Myosin and Kinesin motor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13542.2 GenPept UniProtKB/Swiss-Prot:P13542

Gene LinkOut

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