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Myf6 myogenic factor 6 [ Mus musculus (house mouse) ]

Gene ID: 17878, updated on 9-Dec-2024

Summary

Official Symbol
Myf6provided by MGI
Official Full Name
myogenic factor 6provided by MGI
Primary source
MGI:MGI:97253
See related
Ensembl:ENSMUSG00000035923 AllianceGenome:MGI:97253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRF4; bHLHc4; herculin
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Acts upstream of or within several processes, including regulation of DNA-templated transcription; skeletal muscle cell differentiation; and somitogenesis. Predicted to be located in cytosol; mitotic spindle; and nucleoplasm. Is expressed in several structures, including esophagus; ganglia; limb; paraxial mesenchyme; and skeletal musculature. Used to study alveolar rhabdomyosarcoma. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to human MYF6 (myogenic factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in mammary gland adult (RPKM 1.9), limb E14.5 (RPKM 1.2) and 7 other tissues See more
Orthologs
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Genomic context

See Myf6 in Genome Data Viewer
Location:
10 D1; 10 55.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (107328709..107330584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (107492848..107494723, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene lin-7 homolog A, crumbs cell polarity complex component Neighboring gene STARR-seq mESC enhancer starr_27782 Neighboring gene STARR-seq mESC enhancer starr_27784 Neighboring gene myogenic factor 5 Neighboring gene STARR-seq mESC enhancer starr_27785 Neighboring gene protein tyrosine phosphatase receptor type Q Neighboring gene STARR-seq mESC enhancer starr_27787 Neighboring gene otogelin-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (8)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within muscle tissue morphogenesis PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of myoblast differentiation  
involved_in positive regulation of skeletal muscle fiber development  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
involved_in skeletal muscle cell differentiation  
acts_upstream_of_or_within skeletal muscle cell differentiation PubMed 
acts_upstream_of_or_within skeletal muscle tissue development PubMed 
acts_upstream_of_or_within skeletal muscle tissue development PubMed 
acts_upstream_of_or_within skeletal muscle tissue development PubMed 
involved_in skeletal muscle tissue regeneration  
acts_upstream_of_or_within somitogenesis PubMed 
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in mitotic spindle  
located_in mitotic spindle  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 

General protein information

Preferred Names
myogenic factor 6
Names
muscle-specific regulatory factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008657.3NP_032683.1  myogenic factor 6

    See identical proteins and their annotated locations for NP_032683.1

    Status: VALIDATED

    Source sequence(s)
    AC155168
    Consensus CDS
    CCDS24162.1
    UniProtKB/Swiss-Prot
    P15375
    UniProtKB/TrEMBL
    Q0VEJ7
    Related
    ENSMUSP00000047529.4, ENSMUST00000044210.5
    Conserved Domains (2) summary
    pfam00010
    Location:94145
    HLH; Helix-loop-helix DNA-binding domain
    pfam01586
    Location:393
    Basic; Myogenic Basic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    107328709..107330584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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