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hacd-1 Hydroxy-Acyl-CoA Dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 178638, updated on 23-Nov-2023

Summary

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Gene symbol
hacd-1
Gene description
Hydroxy-Acyl-CoA Dehydrogenase
Primary source
WormBase:WBGene00019978
Locus tag
CELE_R09B5.6
See related
AllianceGenome:WB:WBGene00019978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (1460369..1461613)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glyco_18 domain-containing protein Neighboring gene Solute carrier family 40 member Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. Svensk E, et al. PLoS Genet, 2013. PMID 24068966, Free PMC Article
  2. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert S, et al. Genes Dev, 2006 May 1. PMID 16651656, Free PMC Article
  3. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article
  4. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hydroxy-Acyl-CoA Dehydrogenase
NP_503421.1
  • Product from WormBase gene class hacd;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1460369..1461613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071020.10 → NP_503421.1  Hydroxy-Acyl-CoA Dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503421.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44608
    Conserved Domains (3) summary
    COG1250
    Location:13 → 299
    FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    pfam00725
    Location:202 → 299
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:13 → 200
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
Nucleotide Protein
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