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Mx2 MX dynamin-like GTPase 2 [ Mus musculus (house mouse) ]

Gene ID: 17858, updated on 27-Feb-2024

Summary

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Official Symbol
Mx2provided by MGI
Official Full Name
MX dynamin-like GTPase 2provided by MGI
Primary source
MGI:MGI:97244
See related
Ensembl:ENSMUSG00000023341 AllianceGenome:MGI:97244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mx-2
Summary
This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to vesicular stomatitis virus, a member of the rhabdovirus family, but not to influenza virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a frameshift that inactivates this gene product. [provided by RefSeq, Jul 2008]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Ubiquitous expression in liver E18 (RPKM 1.6), large intestine adult (RPKM 1.0) and 27 other tissues See more
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Genomic context

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See Mx2 in Genome Data Viewer
Location:
16 C4; 16 57.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97337281..97362101)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97536081..97560901)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41629 Neighboring gene MX dynamin-like GTPase 1 Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene STARR-seq mESC enhancer starr_41630 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41631 Neighboring gene STARR-seq mESC enhancer starr_41632 Neighboring gene transmembrane protease, serine 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97814757-97815058 Neighboring gene STARR-seq mESC enhancer starr_41635 Neighboring gene predicted gene, 41512

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Mx2 protein inhibits hantavirus but not influenza virus replication. Jin HK, et al. Arch Virol, 2001. PMID 11266216
  2. Identification of the murine Mx2 gene: interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus. Jin HK, et al. J Virol, 1999 Jun. PMID 10233954, Free PMC Article
  3. ProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis. Imbert A, et al. Sci Data, 2021 Dec 3. PMID 34862403, Free PMC Article
  4. Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor. Nürnberger C, et al. J Virol, 2016 Dec 1. PMID 27654285, Free PMC Article
  5. INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. LINDENMANN J. Proc Soc Exp Biol Med, 1964 Jun. PMID 14193387

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid has been characterized.
    Title: Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to type I interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to virus TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-induced GTP-binding protein Mx2
Names
myxovirus (influenza virus) resistance 2
myxovirus resistance protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013606.1 → NP_038634.1  interferon-induced GTP-binding protein Mx2

    See identical proteins and their annotated locations for NP_038634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. This variant is not expressed in the mouse reference genome strain.
    Source sequence(s)
    AB029920
    UniProtKB/Swiss-Prot
    Q922L4, Q9WVP9
    Conserved Domains (3) summary
    cd08771
    Location:61 → 333
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    pfam01031
    Location:254 → 539
    Dynamin_M; Dynamin central region
    pfam02212
    Location:567 → 653
    GED; Dynamin GTPase effector domain

RNA

  1. NR_003508.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant is expressed by the mouse reference genome strain.
    Source sequence(s)
    AI528743, AK143831, CT009632
    Related
    ENSMUST00000188251.7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    97337281..97362101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVP9.2 GenPept UniProtKB/Swiss-Prot:Q9WVP9

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