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Usp34 ubiquitin specific peptidase 34 [ Mus musculus (house mouse) ]

Gene ID: 17847, updated on 5-Mar-2024

Summary

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Official Symbol
Usp34provided by MGI
Official Full Name
ubiquitin specific peptidase 34provided by MGI
Primary source
MGI:MGI:109473
See related
Ensembl:ENSMUSG00000056342 AllianceGenome:MGI:109473
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Murr2; A530081C03Rik
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and protein K48-linked deubiquitination. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.8), CNS E14 (RPKM 10.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Usp34 in Genome Data Viewer
Location:
11 A3.2; 11 14.29 cM
Exon count:
80
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23256433..23440560)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23303185..23490560)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28906 Neighboring gene predicted gene, 24398 Neighboring gene STARR-seq mESC enhancer starr_28907 Neighboring gene STARR-seq mESC enhancer starr_28908 Neighboring gene STARR-positive B cell enhancer ABC_E729 Neighboring gene exportin 1 Neighboring gene STARR-seq mESC enhancer starr_28911 Neighboring gene RIKEN cDNA 1700030C12 gene Neighboring gene STARR-positive B cell enhancer ABC_E9818 Neighboring gene predicted gene, 22753 Neighboring gene STARR-seq mESC enhancer starr_28912 Neighboring gene RIKEN cDNA 1700093K21 gene Neighboring gene STARR-seq mESC enhancer starr_28914 Neighboring gene STARR-seq mESC enhancer starr_28915 Neighboring gene AHA1, activator of heat shock protein ATPase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells. Oh E, et al. Cell Signal, 2017 Aug. PMID 28499884
  2. Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling. Li Q, et al. J Bone Miner Res, 2020 Aug. PMID 32212276
  3. Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry. Dai J, et al. J Proteome Res, 2007 Jan. PMID 17203969
  4. Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling. Guo YC, et al. EMBO J, 2018 Oct 15. PMID 30181118, Free PMC Article
  5. Mouse U2af1-rs1 is a neomorphic imprinted gene. Nabetani A, et al. Mol Cell Biol, 1997 Feb. PMID 9001233, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-kappaB Signaling.
    Title: Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
  2. data indicate that USP34 is required for osteogenic differentiation and bone formation.
    Title: Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.
  3. the role of USP34 on epithelial-mesenchymal (EMT) induction and its effects on mammary epithelial stem cells, was investigated.
    Title: Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 34
Names
U2af1-rs1 region 2
deubiquitinating enzyme 34
ubiquitin specific protease 34
ubiquitin thioesterase 34
ubiquitin thiolesterase 34
ubiquitin-specific-processing protease 34
NP_001177330.2
XP_006514628.1
XP_006514629.1
XP_006514630.1
XP_017169806.1
XP_030101492.1
XP_030101493.1
XP_036012290.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190401.2 → NP_001177330.2  ubiquitin carboxyl-terminal hydrolase 34

    See identical proteins and their annotated locations for NP_001177330.2

    Status: INFERRED

    Source sequence(s)
    AL672004, AL672049, AL772359, AL928722
    Consensus CDS
    CCDS56763.1
    UniProtKB/Swiss-Prot
    A2AF26, A2AF27, A2AF77, Q3UF93, Q3UPN0, Q6P563, Q6ZQ93, Q7TMJ6, Q8CCH0
    UniProtKB/TrEMBL
    F6WJB7
    Related
    ENSMUSP00000137430.2, ENSMUST00000180046.8
    Conserved Domains (2) summary
    cd02659
    Location:1929 → 2278
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1931 → 2273
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23256433..23440560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514566.4 → XP_006514629.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X2

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1918 → 2267
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_006514565.3 → XP_006514628.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X1

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1930 → 2279
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  3. XM_006514567.3 → XP_006514630.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X4

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1930 → 2279
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  4. XM_017314317.3 → XP_017169806.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X5

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1929 → 2278
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  5. XM_036156397.1 → XP_036012290.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X3

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (2) summary
    cd02659
    Location:1892 → 2241
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12030
    Location:2359 → 2692
    DUF3517; Domain of unknown function (DUF3517)

  6. XM_030245632.2 → XP_030101492.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X6

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1731 → 2080
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  7. XM_030245633.2 → XP_030101493.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X7

    UniProtKB/TrEMBL
    F6WJB7
    Conserved Domains (1) summary
    cd02659
    Location:1719 → 2068
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQ93.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ93

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