Mast2 microtubule associated serine/threonine kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mast2provided by MGI
Official Full Name: microtubule associated serine/threonine kinase 2provided by MGI
Primary source: MGI:MGI:894676
See related: Ensembl:ENSMUSG00000003810 AllianceGenome:MGI:894676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtssk; MAST205
Summary: Enables several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Involved in protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Located in microtubule cytoskeleton. Is expressed in central nervous system; lung epithelium; retina; and testis. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 24.2), CNS E18 (RPKM 23.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.1 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116163957..116321420, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116306760..116464223, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAST205 regulates NHE3 activity and, although the precise mechanism is yet to be determined, MAST205 appears to inhibit NHE3 activity through a phosphorylation-dependent mechanism.
Title: Coexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.
MAST205 is part of the macrophage lipopolysaccharide signal transduction pathway leading to activation of NF-kappa B.
Title: Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma receptor control IL-12 p40 synthesis and NF-kappa B activation.
MAST205 functions as a scaffolding protein controlling TRAF6 activity and, therefore, plays an important role in regulating inflammatory responses.
Title: Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235008

Mast2 (e-PCR), detects polymorphism
- UniSTS:527420

MARC_14431-14432:1010078425:1 (e-PCR)
- UniSTS:267667

D4Mit200 (e-PCR), detects polymorphism
- UniSTS:129981

AU048167 (e-PCR)
- UniSTS:109805

RH65021 (e-PCR)
- UniSTS:33279

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatid differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 2

Names: microtubule associated testis specific serine/threonine protein kinase

NP_001036208.1

EC 2.7.11.1

NP_001355990.1

EC 2.7.11.1

NP_001355991.1

EC 2.7.11.1

NP_032667.2

EC 2.7.11.1

XP_006502897.1

EC 2.7.11.1

XP_006502898.1

EC 2.7.11.1

XP_006502899.1

EC 2.7.11.1

XP_006502902.1

EC 2.7.11.1

XP_030109157.1

EC 2.7.11.1

XP_036019689.1

EC 2.7.11.1

XP_036019690.1

EC 2.7.11.1

XP_036019691.1

EC 2.7.11.1

XP_036019692.1

EC 2.7.11.1

XP_036019693.1

EC 2.7.11.1

XP_036019694.1

EC 2.7.11.1

XP_036019695.1

EC 2.7.11.1

XP_036019696.1

EC 2.7.11.1

XP_036019697.1

EC 2.7.11.1

XP_036019698.1

EC 2.7.11.1

XP_036019699.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042743.2 → NP_001036208.1 microtubule-associated serine/threonine-protein kinase 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

BC060703, BY597795, CB246117, CJ182836

Consensus CDS

CCDS38850.1

UniProtKB/Swiss-Prot

Q60592, Q6P9M1, Q8CHD1

UniProtKB/TrEMBL

B1AST7, E9Q1Q1

Related

ENSMUSP00000102093.3, ENSMUST00000106484.9

Conserved Domains (4) summary

smart00220
Location:520 → 793

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1110 → 1191

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:519 → 798

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 483

DUF1908; Domain of unknown function (DUF1908)
NM_001369061.1 → NP_001355990.1 microtubule-associated serine/threonine-protein kinase 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AL627394, AL669953, AL670603

UniProtKB/Swiss-Prot

Q60592, Q6P9M1, Q8CHD1

Conserved Domains (3) summary

cd00992
Location:1110 → 1191

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:519 → 798

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 483

DUF1908; Domain of unknown function (DUF1908)
NM_001369062.1 → NP_001355991.1 microtubule-associated serine/threonine-protein kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL627394, AL669953, AL670603

UniProtKB/Swiss-Prot

Q60592, Q6P9M1, Q8CHD1

Conserved Domains (3) summary

cd00992
Location:1103 → 1184

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:512 → 791

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 476

DUF1908; Domain of unknown function (DUF1908)
NM_008641.3 → NP_032667.2 microtubule-associated serine/threonine-protein kinase 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

BC060703, BU055783, BU610780, BU701350, BU706282, BY597795, CB246117, CF743521, CJ182836, CK633885, CN696803

Consensus CDS

CCDS38849.1

UniProtKB/Swiss-Prot

Q60592, Q6P9M1, Q8CHD1

UniProtKB/TrEMBL

B1AST8, E9QLW6

Related

ENSMUSP00000003908.6, ENSMUST00000003908.12

Conserved Domains (4) summary

smart00220
Location:513 → 786

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00992
Location:1103 → 1184

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:512 → 791

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 476

DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

116163957..116321420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502836.5 → XP_006502899.1 microtubule-associated serine/threonine-protein kinase 2 isoform X5

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:959 → 1040

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_006502835.5 → XP_006502898.1 microtubule-associated serine/threonine-protein kinase 2 isoform X4

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:966 → 1047

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:375 → 654

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:58 → 339

DUF1908; Domain of unknown function (DUF1908)
XM_030253297.2 → XP_030109157.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_006502834.3 → XP_006502897.1 microtubule-associated serine/threonine-protein kinase 2 isoform X1

UniProtKB/TrEMBL

A0A668KL31

Related

ENSMUSP00000159199.2, ENSMUST00000239177.2

Conserved Domains (3) summary

cd00992
Location:1024 → 1105

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:433 → 712

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:116 → 397

DUF1908; Domain of unknown function (DUF1908)
XM_036163803.1 → XP_036019696.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_036163800.1 → XP_036019693.1 microtubule-associated serine/threonine-protein kinase 2 isoform X8

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:952 → 1033

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:361 → 640

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 325

DUF1908; Domain of unknown function (DUF1908)
XM_036163797.1 → XP_036019690.1 microtubule-associated serine/threonine-protein kinase 2 isoform X3

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:1017 → 1098

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:426 → 705

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:116 → 390

DUF1908; Domain of unknown function (DUF1908)
XM_036163796.1 → XP_036019689.1 microtubule-associated serine/threonine-protein kinase 2 isoform X2

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:1017 → 1098

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:426 → 705

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:116 → 390

DUF1908; Domain of unknown function (DUF1908)
XM_036163802.1 → XP_036019695.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_036163798.1 → XP_036019691.1 microtubule-associated serine/threonine-protein kinase 2 isoform X6

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:959 → 1040

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_036163806.1 → XP_036019699.1 microtubule-associated serine/threonine-protein kinase 2 isoform X11

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_036163805.1 → XP_036019698.1 microtubule-associated serine/threonine-protein kinase 2 isoform X11

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_036163799.1 → XP_036019692.1 microtubule-associated serine/threonine-protein kinase 2 isoform X7

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:959 → 1040

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_036163801.1 → XP_036019694.1 microtubule-associated serine/threonine-protein kinase 2 isoform X9

UniProtKB/TrEMBL

A0A668KL31, A0A668KLF8

Related

ENSMUSP00000159270.2, ENSMUST00000239239.2

Conserved Domains (3) summary

cd00992
Location:952 → 1033

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:361 → 640

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 325

DUF1908; Domain of unknown function (DUF1908)
XM_036163804.1 → XP_036019697.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10

UniProtKB/TrEMBL

A0A668KL31

Conserved Domains (3) summary

cd00992
Location:810 → 891

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:219 → 498

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:1 → 183

DUF1908; Domain of unknown function (DUF1908)
XM_006502839.1 → XP_006502902.1 microtubule-associated serine/threonine-protein kinase 2 isoform X12

UniProtKB/TrEMBL

Q9DBV8

Conserved Domains (3) summary

smart00133
Location:2 → 31

S_TK_X; Extension to Ser/Thr-type protein kinases

cd00992
Location:317 → 398

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02163
Location:347 → 455

Peptidase_M50; Peptidase family M50