Map1a microtubule-associated protein 1 A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map1aprovided by MGI
Official Full Name: microtubule-associated protein 1 Aprovided by MGI
Primary source: MGI:MGI:1306776
See related: Ensembl:ENSMUSG00000027254 AllianceGenome:MGI:1306776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mtap1; moth1; Mtap-1; Mtap1a; 6330416M19Rik
Summary: Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and negative regulation of protein localization to microtubule. Acts upstream of or within photoreceptor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and photoreceptor outer segment. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 53.8), frontal lobe adult (RPKM 50.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.37 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (121119608..121141313)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (121289590..121310832)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model.
Title: Phosphorylation of MAP 1A regulates hyperphosphorylation of Tau in Alzheimer's disease model.
Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia.
Title: Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia.
Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain.
Title: Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain.
Mutant mice lacking MAP1A exhibited reduced synaptic plasticity.
Title: Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.
Although MAP1A and MAP1B protein levels are not affected in the tulp1-/- retina, they are no longer localized to the outer segment of photoreceptors.
Title: Interaction of tubby-like protein-1 (Tulp1) and microtubule-associated protein (MAP) 1A and MAP1B in the mouse retina.
The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A, MAP1B, and MAP1S) and alpha1-syntrophin is direct and occurs through the pleckstrin homology domain 2 (PH2).
Title: The light chains of microtubule-associated proteins MAP1A and MAP1B interact with α1-syntrophin in the central and peripheral nervous system.
It was demonstrated that the gene Mtap1a modifies retinal degeneration in Tub(tub/tub) and Tulp1(tm1Pjn/tm1Pjn) mice.
Title: An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.
Data indicate that protective alleles of Mtap1a are not sufficient to rescue DW/J-Pou1f1dw/dw mutant hearing.
Title: A modifier gene alleviates hypothyroidism-induced hearing impairment in Pou1f1dw dwarf mice.
there is a novel interaction between the C-terminal tail of the BKCa channel and the light chain of MAP1A, which enables channel association with and modulation by the cytoskeleton
Title: Direct interaction between BKCa potassium channel and microtubule-associated protein 1A.
Microtubule-associated protein light chain 2 interacts with the intracellular C-terminal tail of stargazin.
Title: Microtubule-associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

QTL (2) 1 citation
Spontaneous (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

stSG627752 (e-PCR)
- UniSTS:457801

D2Mit445 (e-PCR), detects polymorphism
- UniSTS:129355

AI853608 (e-PCR)
- UniSTS:165199

MDB0962 (e-PCR)
- UniSTS:125041

AI711500 (e-PCR)
- UniSTS:243922

D2Dcr65 (e-PCR), detects polymorphism
- UniSTS:507624

G36396 (e-PCR)
- UniSTS:28670

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal anchor activity	IDA Inferred from Direct Assay more info	PubMed
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein localization to microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal protein transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IDA Inferred from Direct Assay more info	PubMed
involved_in voluntary musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic branch	ISO Inferred from Sequence Orthology more info
located_in dendritic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
NOT located_in distal axon	NAS Non-traceable Author Statement more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in primary dendrite	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: microtubule-associated protein 1A

Names: MAP-1A; modifier of tubby hearing 1; short MAP1A; short microtubule-associated protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173506.1 → NP_001166977.1 microtubule-associated protein 1A isoform 2

See identical proteins and their annotated locations for NP_001166977.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.

Source sequence(s)

AK147474, AK160546, AL845466, BQ175021, CJ116735

Consensus CDS

CCDS50685.1

UniProtKB/Swiss-Prot

A2ARN9, Q3TQM8, Q3TUV8, Q3UHB7, Q9QYR6, Q9QZH9, Q9QZI0, Q9QZI1

Related

ENSMUSP00000106269.2, ENSMUST00000110639.8

Conserved Domains (1) summary

cl23716
Location:46 → 149

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
NM_032393.2 → NP_115769.1 microtubule-associated protein 1A isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF182213, AK147474, AK160546, AL845466, BQ175021

Consensus CDS

CCDS38215.1

UniProtKB/TrEMBL

A2ARP8

Related

ENSMUSP00000092223.4, ENSMUST00000094639.10

Conserved Domains (1) summary

cl23716
Location:284 → 387

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

121119608..121141313

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498872.5 → XP_006498935.1 microtubule-associated protein 1A isoform X1

Conserved Domains (3) summary

PTZ00121
Location:1567 → 1890

PTZ00121; MAEBL; Provisional

PHA03247
Location:2416 → 2863

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1986 → 2355

PHA03307; transcriptional regulator ICP4; Provisional