mt-Co2 cytochrome c oxidase II, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Co2provided by MGI
Official Full Name: cytochrome c oxidase II, mitochondrialprovided by MGI
Primary source: MGI:MGI:102503
See related: AllianceGenome:MGI:102503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX2
Summary: Predicted to enable copper ion binding activity and oxidoreductase activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in ATP synthesis coupled electron transport; positive regulation of cellular biosynthetic process; and positive regulation of necrotic cell death. Located in mitochondrion. Is expressed in embryo; epiblast; heart; liver; and metanephros. Orthologous to several human genes including MTCO2P12 (MT-CO2 pseudogene 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (7013..7696)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (7013..7696)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TT-10 may elevate YAP and repair mouse uterine damage resulting from the inhibition effect of ibuprofen on COX2-PGE2 and YAP.
Title: TT-10 may elevate YAP and repair mouse uterine damage resulting from the inhibition effect of ibuprofen on COX2-PGE2 and YAP.
BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
Title: BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
Tested the roles of COX-2 and EP receptors in VEGF-C and -D production by a highly metastatic COX-2 expressing murine breast cancer cell line C3L5.
Title: Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model.
Rickettsia conorii infection of susceptible mice, therefore, results in selective regulation of the expression of HO-1 and COX-2 in a manner dependent on the target host tissue's cellular environment and the propensity of infection with rickettsiae.
Title: Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis.
Data suggest that physical exercise attenuates age-related changes in mitochondrial COX biogenesis and p53 activity targeting SCO2 and mitochondria, and thereby induces antisenescent and protective effects in cardiac muscle.
Title: Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.
Cytochrome c oxidase subunit II is inactivated by mutant SOD1 in motor neurons; this inactivation requires nitric oxide.
Title: Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide.
GILZ inhibits COX-2 expression by blocking NF-kappaB nuclear translocation.
Title: Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression.
COX-2-dependent production of PGD2 followed by eosinophil recruitment into the airways via a CRTH2 receptor are the major pathogenetic factors responsible for the dsRNA-induced enhancement of airway inflammation and responsiveness.
Title: Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation.
co-ordinated post-translational modifications of p65 and histone H3 involving phosphorylation and acetylation drive COX-2-dependent transcriptional activation of the MMP-9 gene in response to challenge of macrophages with M. avium.
Title: Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification.
renal calcineurin isoforms are subject to normal developmental regulation and they may play a role in postnatal kidney development via interaction with COX-2
Title: Developmental regulation of calcineurin isoforms in the rodent kidney: association with COX-2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk25g03.x1 (e-PCR)
- UniSTS:200706

RH136459 (e-PCR)
- UniSTS:210445

RH125504 (e-PCR)
- UniSTS:162322

RH136229 (e-PCR)
- UniSTS:210223

RH136241 (e-PCR)
- UniSTS:210235

RH136529 (e-PCR)
- UniSTS:210511

NoName (e-PCR)
- UniSTS:234086

NoName (e-PCR)
- UniSTS:234087

NoName (e-PCR)
- UniSTS:234088

RH136597 (e-PCR)
- UniSTS:210577

RH136345 (e-PCR)
- UniSTS:210335

PMC307645P1 (e-PCR)
- UniSTS:272585

RH136391 (e-PCR)
- UniSTS:210381

RH136413 (e-PCR)
- UniSTS:210403

RH136419 (e-PCR)
- UniSTS:210409

Homology

Orthologs from OrthoDB

COII; COXII

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in respirasome	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	ISO Inferred from Sequence Orthology more info