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Mstn myostatin [ Mus musculus (house mouse) ]

Gene ID: 17700, updated on 11-Apr-2024

Summary

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Official Symbol
Mstnprovided by MGI
Official Full Name
myostatinprovided by MGI
Primary source
MGI:MGI:95691
See related
Ensembl:ENSMUSG00000026100 AllianceGenome:MGI:95691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cmpt; Gdf8
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]
Expression
Biased expression in mammary gland adult (RPKM 4.7), limb E14.5 (RPKM 3.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Mstn in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53100799..53107238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53061640..53068079)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907 Neighboring gene STARR-seq mESC enhancer starr_00910 Neighboring gene predicted gene, 24349 Neighboring gene RIKEN cDNA 1700019A02 gene Neighboring gene PMS1 homolog 1, mismatch repair system component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Divergent effects of myostatin inhibition on cardiac and skeletal muscles in a mouse model of pressure overload. Shi C, et al. Am J Physiol Heart Circ Physiol, 2023 Jul 1. PMID 37294894
  2. Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle. Wang X, et al. Int J Mol Sci, 2022 Dec 11. PMID 36555347, Free PMC Article
  3. Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle. Gu M, et al. Int J Mol Sci, 2022 Nov 8. PMID 36430183, Free PMC Article
  4. [Mstn knockdown promotes intramuscular fatty acid metabolism by β oxidation via the up-regulation of Cpt1b]. Guo Y, et al. Sheng Wu Gong Cheng Xue Bao, 2022 Aug 25. PMID 36002433
  5. Myostain is involved in ginsenoside Rb1-mediated anti-obesity. Li HS, et al. Pharm Biol, 2022 Dec. PMID 35639355, Free PMC Article

See all (354) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice.
    Title: Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice.
  2. Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
    Title: Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain.
  3. The effect of modification of DNA interference on myostatin gene expression in mice.
    Title: The effect of modification of DNA interference on myostatin gene expression in mice.
  4. Myostatin and the Heart.
    Title: Myostatin and the Heart.
  5. GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.
    Title: GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury.
  6. Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
    Title: Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
  7. Divergent effects of myostatin inhibition on cardiac and skeletal muscles in a mouse model of pressure overload.
    Title: Divergent effects of myostatin inhibition on cardiac and skeletal muscles in a mouse model of pressure overload.
  8. Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction.
    Title: Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction.
  9. Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
    Title: Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle.
  10. Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle.
    Title: Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle.
Submit: New GeneRIF Correction See all GeneRIFs (258)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124261, MGC124262, MGC124263

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast migration involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of skeletal muscle tissue growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle satellite cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
growth/differentiation factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010834.3 → NP_034964.1  growth/differentiation factor 8 preproprotein

    See identical proteins and their annotated locations for NP_034964.1

    Status: REVIEWED

    Source sequence(s)
    AK132415, AK142222
    Consensus CDS
    CCDS14950.1
    UniProtKB/Swiss-Prot
    O08689
    UniProtKB/TrEMBL
    Q0VGH1, Q3ZAS9, Q540E2
    Related
    ENSMUSP00000027269.6, ENSMUST00000027269.7
    Conserved Domains (2) summary
    pfam00688
    Location:37 → 250
    TGFb_propeptide; TGF-beta propeptide
    cd19388
    Location:269 → 376
    TGF_beta_GDF8; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    53100799..53107238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08689.1 GenPept UniProtKB/Swiss-Prot:O08689

Gene LinkOut

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