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Msmb beta-microseminoprotein [ Mus musculus (house mouse) ]

Gene ID: 17695, updated on 5-Mar-2024

Summary

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Official Symbol
Msmbprovided by MGI
Official Full Name
beta-microseminoproteinprovided by MGI
Primary source
MGI:MGI:97166
See related
Ensembl:ENSMUSG00000021907 AllianceGenome:MGI:97166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIP; PSP94; beta-MSP
Summary
Predicted to be located in extracellular region. Is expressed in anterior prostate gland; prostate gland dorsolateral lobe; testis; and ventral prostate gland. Used to study prostate cancer. Orthologous to human MSMB (microseminoprotein beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31863980..31880284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32142023..32158327)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36333 Neighboring gene diphthamine biosynthesis 3 Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_36334 Neighboring gene STARR-seq mESC enhancer starr_36335 Neighboring gene predicted gene, 57612 Neighboring gene STARR-seq mESC enhancer starr_36337 Neighboring gene STARR-seq mESC enhancer starr_36339 Neighboring gene predicted gene, 41127 Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene nuclear receptor coactivator 4 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High milk consumption does not affect prostate tumor progression in two mouse models of benign and neoplastic lesions. Bernichtein S, et al. PLoS One, 2015. PMID 25938513, Free PMC Article
  2. Bub1 up-regulation and hyperphosphorylation promote malignant transformation in SV40 tag-induced transgenic mouse models. Guo C, et al. Mol Cancer Res, 2006 Dec. PMID 17189386
  3. Histopathological characteristics of a novel knock-in mouse prostate cancer model. Wu G, et al. Braz J Med Biol Res, 2006 Jun. PMID 16751981
  4. Application of Gleason analogous grading system and flow cytometry DNA analysis in a novel knock-in mouse prostate cancer model. Wu G, et al. Postgrad Med J, 2006 Jan. PMID 16397079, Free PMC Article
  5. Establishment of a serum tumor marker for preclinical trials of mouse prostate cancer models. Huizen IV, et al. Clin Cancer Res, 2005 Nov 1. PMID 16278416

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Establishment and characterization of PSP94 antibodies contribute to the potential for PSP94 as a new vector gene for prostate cancer gene therapy
    Title: Mouse PSP94 expression is prostate tissue-specific as demonstrated by a comparison of multiple antibodies against recombinant proteins.
  2. knock-in mutation provides model for prostatic neoplasm
    Title: A novel knock-in prostate cancer model demonstrates biology similar to that of human prostate cancer and suitable for preclinical studies.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-microseminoprotein
Names
PSP-94
beta-inhibin
prostate secreted seminal plasma protein
prostate secretory protein of 94 amino acids
prostatic inhibin protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020597.3 → NP_065622.1  beta-microseminoprotein precursor

    See identical proteins and their annotated locations for NP_065622.1

    Status: VALIDATED

    Source sequence(s)
    AC154532
    Consensus CDS
    CCDS36862.1
    UniProtKB/Swiss-Prot
    O08540
    Related
    ENSMUSP00000022464.7, ENSMUST00000022464.14
    Conserved Domains (1) summary
    pfam05825
    Location:21 → 113
    PSP94; Beta-microseminoprotein (PSP-94)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31863980..31880284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315907.2 → XP_017171396.1  beta-microseminoprotein isoform X1

    Conserved Domains (1) summary
    pfam05825
    Location:96 → 188
    PSP94; Beta-microseminoprotein (PSP-94)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08540.1 GenPept UniProtKB/Swiss-Prot:O08540

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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