U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hsp-110 Heat shock protein 110 [ Caenorhabditis elegans ]

Gene ID: 176195, updated on 25-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
hsp-110
Gene description
Heat shock protein 110
Primary source
WormBase:WBGene00016250
Locus tag
CELE_C30C11.4
See related
AllianceGenome:WB:WBGene00016250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in determination of adult lifespan; protein folding; and response to topologically incorrect protein. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to several human genes including HSPA4 (heat shock protein family A (Hsp70) member 4) and HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (8443910..8446909, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich) domain-bearing protein 96 Neighboring gene DDRGK domain-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Duplication of hsp-110 Is Implicated in Differential Success of Globodera Species under Climate Change. Jones LM, et al. Mol Biol Evol, 2018 Oct 1. PMID 29955862, Free PMC Article
  2. The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species. Tittelmeier J, et al. EMBO J, 2020 Jul 1. PMID 32449565, Free PMC Article
  3. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nillegoda NB, et al. Nature, 2015 Aug 13. PMID 26245380, Free PMC Article
  4. A genetic screening strategy identifies novel regulators of the proteostasis network. Silva MC, et al. PLoS Genet, 2011 Dec. PMID 22242008, Free PMC Article
  5. Expression profile of heat shock response factors during hookworm larval activation and parasitic development. Gelmedin V, et al. Mol Biochem Parasitol, 2015 Jul. PMID 26296769, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The HSP110/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species.
    Title: The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to topologically incorrect protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Heat shock protein 110
NP_498868.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8443910..8446909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066467.7 → NP_498868.1  Heat shock protein 110 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05036
    Conserved Domains (2) summary
    cd10228
    Location:2 → 387
    HSPA4_like_NDB; Nucleotide-binding domain of 105/110 kDa heat shock proteins including HSPA4 and similar proteins
    pfam00012
    Location:3 → 650
    HSP70; Hsp70 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05036.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous