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Irag1 inositol 1,4,5-triphosphate receptor associated 1 [ Mus musculus (house mouse) ]

Gene ID: 17540, updated on 21-Apr-2024

Summary

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Official Symbol
Irag1provided by MGI
Official Full Name
inositol 1,4,5-triphosphate receptor associated 1provided by MGI
Primary source
MGI:MGI:1338023
See related
Ensembl:ENSMUSG00000005611 AllianceGenome:MGI:1338023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irag; Ris1; Mrvi1
Summary
This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Expression
Biased expression in bladder adult (RPKM 34.2), subcutaneous fat pad adult (RPKM 20.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.9 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110467464..110582116, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110868257..110982909, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene ring finger protein 141 Neighboring gene STARR-positive B cell enhancer ABC_E2250 Neighboring gene STARR-seq mESC enhancer starr_19833 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene STARR-seq mESC enhancer starr_19834 Neighboring gene predicted gene 16336 Neighboring gene STARR-seq mESC enhancer starr_19835 Neighboring gene STARR-seq mESC enhancer starr_19836 Neighboring gene STARR-positive B cell enhancer ABC_E9701 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene eukaryotic translation initiation factor 4, gamma 2 Neighboring gene predicted gene, 23262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly. Majer M, et al. Int J Mol Sci, 2021 May 21. PMID 34064290, Free PMC Article
  2. IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension. Biswas S, et al. Cells, 2020 Oct 13. PMID 33066124, Free PMC Article
  3. IRAG and novel PKG targeting in the cardiovascular system. Schlossmann J, et al. Am J Physiol Heart Circ Physiol, 2011 Sep. PMID 21666108
  4. InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases. Masuda W, et al. J Biol Chem, 2010 Nov 26. PMID 20876535, Free PMC Article
  5. Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation. Schinner E, et al. Platelets, 2011. PMID 21244222

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IRAG1 Deficient Mice Develop PKG1beta Dependent Pulmonary Hypertension.
    Title: IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension.
  2. cGKIbeta signaling via IRAG is essential for regulation of smooth muscle tone and of intracellular calcium by NO and by atrial natriuretic peptide.
    Title: IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
  3. conclude that cGMP-dependent relaxation of hormone receptor-triggered smooth muscle contraction essentially depends on the interaction of cGKI-IRAG with IP(3)RI
    Title: IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase.
  4. Reports use of non-AUG (CUG) translation initiation codon in one of the transcript variants of MRVI1 gene in mouse and human.
    Title: Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol 1,4,5-triphosphate receptor associated 1
Names
JAW1-related protein MRVI1
MRV integration site 1
inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
murine retrovirus integration site 1 protein
protein MRVI1
retroviral integration site 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194464.3 → NP_919446.2  inositol 1,4,5-triphosphate receptor associated 1

    See identical proteins and their annotated locations for NP_919446.2

    Status: REVIEWED

    Source sequence(s)
    AC159206, AC184052, AK020536, AK141821
    Consensus CDS
    CCDS21749.1
    UniProtKB/Swiss-Prot
    Q3U069, Q9R2C5, Q9WUX5
    Related
    ENSMUSP00000005751.7, ENSMUST00000005751.13
    Conserved Domains (1) summary
    pfam05781
    Location:272 → 856
    MRVI1; MRVI1 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110467464..110582116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507416.3 → XP_006507479.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

    See identical proteins and their annotated locations for XP_006507479.1

    UniProtKB/Swiss-Prot
    Q3U069, Q9R2C5, Q9WUX5
    Related
    ENSMUSP00000114578.2, ENSMUST00000125758.8
    Conserved Domains (1) summary
    pfam05781
    Location:272 → 856
    MRVI1; MRVI1 protein

  2. XM_006507415.4 → XP_006507478.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X2

    See identical proteins and their annotated locations for XP_006507478.1

    UniProtKB/Swiss-Prot
    Q3U069, Q9R2C5, Q9WUX5
    Conserved Domains (1) summary
    pfam05781
    Location:272 → 856
    MRVI1; MRVI1 protein

  3. XM_036152758.1 → XP_036008651.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

    UniProtKB/TrEMBL
    Q3UR44
    Conserved Domains (1) summary
    pfam05781
    Location:24 → 608
    MRVI1; MRVI1 protein

  4. XM_006507418.5 → XP_006507481.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X3

    UniProtKB/TrEMBL
    Q3UR44
    Conserved Domains (1) summary
    pfam05781
    Location:24 → 608
    MRVI1; MRVI1 protein

  5. XM_011241686.1 → XP_011239988.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U069, Q9R2C5, Q9WUX5
    Related
    ENSMUSP00000120045.2, ENSMUST00000127935.8
    Conserved Domains (2) summary
    pfam05781
    Location:289 → 873
    MRVI1; MRVI1 protein
    cl19857
    Location:122 → 213
    DUF2126; Putative amidoligase enzyme (DUF2126)

  6. XM_011241687.4 → XP_011239989.1  inositol 1,4,5-triphosphate receptor associated 1 isoform X4

    Conserved Domains (1) summary
    pfam05781
    Location:337 → 490
    MRVI1; MRVI1 protein

RNA

  1. XR_869664.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010826.5: Suppressed sequence

    Description
    NM_010826.5: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUX5.2 GenPept UniProtKB/Swiss-Prot:Q9WUX5

Gene LinkOut

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