Mpdz multiple PDZ domain crumbs cell polarity complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpdzprovided by MGI
Official Full Name: multiple PDZ domain crumbs cell polarity complex componentprovided by MGI
Primary source: MGI:MGI:1343489
See related: Ensembl:ENSMUSG00000028402 AllianceGenome:MGI:1343489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MUPP1; B930003D11Rik
Summary: Predicted to enable protein C-terminus binding activity. Involved in dendrite development and intracellular protein transport. Acts upstream of or within cell adhesion. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and bicellular tight junction. Part of subapical complex. Is active in synapse. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to human MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 10.3), limb E14.5 (RPKM 8.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C3; 4 38.0 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (81196736..81361112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (81278499..81442897, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos.
Title: PATJ and MPDZ are required for trophectoderm lineage specification in early mouse embryos.
The authors show by magnetic resonance imaging that contrast medium penetrates into the brain ventricles of mice carrying a Mpdz loss-of-function mutation, whereas none is detected in the ventricles of normal mice, implying that the permeability of the choroid plexus epithelial cell monolayer is abnormally high.
Title: Murine MPDZ-linked hydrocephalus is caused by hyperpermeability of the choroid plexus.
Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling.
Title: MPDZ promotes DLL4-induced Notch signaling during angiogenesis.
This work provides a relevant hydrocephalus mouse model and demonstrates that Mpdz is essential to maintain integrity of the ependyma.
Title: Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice.
Variants of the multiple PDZ domain gene Mpdz may contribute to the observed inter-strain variability in opioid tolerance and opioid-induced hyperalgesia by virtue of changes in the level of their expression.
Title: The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia.
MUPP1-PDZ4 domain contained three alpha-helices and six beta-strands in the core. The GLGI motif, L562/A564 on the beta-strand B, and H605/V608/L612 on the alpha-helix B formed a PDZ binding pocket which could bind to the C-terminal of the binding partners.
Title: Biochemical and structural characterization of MUPP1-PDZ4 domain from Mus musculus.
Increased MPDZ expression decreased the severity of ethanol withdrawal, while decreased MPDZ expression increased ethanol withdrawal severity. Decreased MPDZ expression was associated with increased voluntary ethanol consumption.
Title: Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.
neurexin 1 interaction with multi-PDZ domain protein MUPP1
Title: Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1.
Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the caudolateral substantia nigra pars reticulata is crucially involved in risk for alcohol withdrawal.
Title: Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal.
regulates odor responses and activation kinetics of olfactory sensory neurons
Title: The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mpdz (e-PCR), detects polymorphism
- UniSTS:143902

RH135979 (e-PCR)
- UniSTS:209975

D4Mit173 (e-PCR), detects polymorphism
- UniSTS:142465

D4Nds7 (e-PCR), detects polymorphism
- UniSTS:142479

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of subapical complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: multiple PDZ domain protein

Names: multi-PDZ domain protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305284.1 → NP_001292213.1 multiple PDZ domain protein isoform 1

See identical proteins and their annotated locations for NP_001292213.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).

Source sequence(s)

AF326531, AK019164, AK160603, AL670939, CR352325

Consensus CDS

CCDS89768.1

UniProtKB/TrEMBL

B2RQR2, D3YUX2

Related

ENSMUSP00000152533.2, ENSMUST00000220807.2

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1151 → 1242

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1564 → 1625

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
NM_001305286.1 → NP_001292215.1 multiple PDZ domain protein isoform 3

See identical proteins and their annotated locations for NP_001292215.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.

Source sequence(s)

AF326531, AK019164, AK160603, AL670939, CR352325

Consensus CDS

CCDS89767.1

UniProtKB/TrEMBL

D3YUX2

Related

ENSMUSP00000102879.3, ENSMUST00000107258.9

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1137 → 1228

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1517 → 1578

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
NM_010820.3 → NP_034950.2 multiple PDZ domain protein isoform 2

See identical proteins and their annotated locations for NP_034950.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AF326531, AK019164, AK160603, AL670939, CR352325

Consensus CDS

CCDS18292.1

UniProtKB/Swiss-Prot

B7ZNA1, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBX6, Q8VBY0, Q9Z1K3

UniProtKB/TrEMBL

D3YUX2

Related

ENSMUSP00000099894.4, ENSMUST00000102830.10

Conserved Domains (4) summary

pfam09045
Location:6 → 63

L27_2; L27_2

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1137 → 1228

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:1550 → 1611

MPDZ_u10; Unstructured region 10 on multiple PDZ protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

81196736..81361112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537644.5 → XP_006537707.1 multiple PDZ domain protein isoform X2

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1127 → 1218

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1540 → 1601

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006537649.5 → XP_006537712.1 multiple PDZ domain protein isoform X8

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1094 → 1185

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1507 → 1568

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163794.1 → XP_036019687.1 multiple PDZ domain protein isoform X14

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1862 → 1945

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1441 → 1502

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163792.1 → XP_036019685.1 multiple PDZ domain protein isoform X12

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1098 → 1189

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1478 → 1539

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163789.1 → XP_036019682.1 multiple PDZ domain protein isoform X7

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1098 → 1189

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1511 → 1572

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163790.1 → XP_036019683.1 multiple PDZ domain protein isoform X10

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1112 → 1203

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1492 → 1553

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006537647.5 → XP_006537710.1 multiple PDZ domain protein isoform X5

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1112 → 1203

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1525 → 1586

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_011249940.4 → XP_011248242.1 multiple PDZ domain protein isoform X3

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1119 → 1210

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1532 → 1593

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163793.1 → XP_036019686.1 multiple PDZ domain protein isoform X13

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1897 → 1980

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1476 → 1537

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163788.1 → XP_036019681.1 multiple PDZ domain protein isoform X6

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1133 → 1224

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1513 → 1574

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006537643.5 → XP_006537706.1 multiple PDZ domain protein isoform X1

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1133 → 1224

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1546 → 1607

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163791.1 → XP_036019684.1 multiple PDZ domain protein isoform X11

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1901 → 1984

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1480 → 1541

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006537646.5 → XP_006537709.1 multiple PDZ domain protein isoform X4

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1151 → 1242

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1531 → 1592

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_006537650.5 → XP_006537713.1 multiple PDZ domain protein isoform X9

UniProtKB/TrEMBL

D3YUX2

Conserved Domains (4) summary

smart00228
Location:375 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1915 → 1998

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09045
Location:6 → 63

L27_2

pfam16667
Location:1494 → 1555

MPDZ_u10; Unstructured region 10 on multiple PDZ protein
XM_036163795.1 → XP_036019688.1 multiple PDZ domain protein isoform X15

Conserved Domains (3) summary

smart00228
Location:716 → 800

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:274 → 365

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16667
Location:654 → 715

MPDZ_u10; Unstructured region 10 on multiple PDZ protein