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Gbp4 guanylate binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 17472, updated on 11-Apr-2024

Summary

Official Symbol
Gbp4provided by MGI
Official Full Name
guanylate binding protein 4provided by MGI
Primary source
MGI:MGI:97072
See related
Ensembl:ENSMUSG00000079363 AllianceGenome:MGI:97072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpa2; GBP-4; Mag-2; Mpa-2
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to interferon-gamma; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 15.2), bladder adult (RPKM 6.1) and 10 other tissues See more
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Genomic context

See Gbp4 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105263633..105287452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105115767..105139586, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene guanylate-binding protein 8 Neighboring gene STARR-seq mESC enhancer starr_13847 Neighboring gene guanylate-binding protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E1304 Neighboring gene predicted gene, 53274 Neighboring gene predicted gene 9640

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4245

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanylate-binding protein 4
Names
GTP-binding protein 4
guanine nucleotide-binding protein 4
guanylate nucleotide binding protein 4
guanylate-binding protein 4 homolog
macrophage activation 2
NP_001242934.1
NP_001346008.1
NP_001346009.1
NP_001346010.1
NP_001346011.1
NP_032646.2
XP_006534867.1
XP_006534868.1
XP_011247713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256005.1NP_001242934.1  guanylate-binding protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001242934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3.
    Source sequence(s)
    EF494423
    Consensus CDS
    CCDS57368.1
    UniProtKB/Swiss-Prot
    A0A0G2JDT5, A0A0G2JEJ5, A0A0G2JGT4, A4UUI3, B9EJ74, Q61594
    UniProtKB/TrEMBL
    Q5DTF3
    Related
    ENSMUSP00000098522.4, ENSMUST00000100962.8
    Conserved Domains (2) summary
    pfam02841
    Location:289582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001359079.1NP_001346008.1  guanylate-binding protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:302595
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:29300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001359080.1NP_001346009.1  guanylate-binding protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:153446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001359081.1NP_001346010.1  guanylate-binding protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:153446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001359082.1NP_001346011.1  guanylate-binding protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AC123697, AC144914
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:153446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_008620.4NP_032646.2  guanylate-binding protein 4 isoform 2

    See identical proteins and their annotated locations for NP_032646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2) is shorter at the N-terminus compared to isoform 3. Variants 2, 4, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    EF494424
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:153446
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105263633..105287452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534805.4XP_006534868.1  guanylate-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534868.1

    UniProtKB/Swiss-Prot
    A0A0G2JDT5, A0A0G2JEJ5, A0A0G2JGT4, A4UUI3, B9EJ74, Q61594
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:289582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006534804.4XP_006534867.1  guanylate-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006534867.1

    UniProtKB/Swiss-Prot
    A0A0G2JDT5, A0A0G2JEJ5, A0A0G2JGT4, A4UUI3, B9EJ74, Q61594
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:289582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011249411.4XP_011247713.1  guanylate-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011247713.1

    UniProtKB/Swiss-Prot
    A0A0G2JDT5, A0A0G2JEJ5, A0A0G2JGT4, A4UUI3, B9EJ74, Q61594
    UniProtKB/TrEMBL
    Q5DTF3
    Conserved Domains (2) summary
    pfam02841
    Location:289582
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16287
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases