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Cd200 CD200 molecule [ Mus musculus (house mouse) ]

Gene ID: 17470, updated on 21-Apr-2024

Summary

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Official Symbol
Cd200provided by MGI
Official Full Name
CD200 moleculeprovided by MGI
Primary source
MGI:MGI:1196990
See related
Ensembl:ENSMUSG00000022661 AllianceGenome:MGI:1196990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OX2; Mox2
Summary
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Involved in negative regulation of cell population proliferation; negative regulation of macrophage activation; and negative regulation of neuroinflammatory response. Located in cell surface. Is expressed in several structures, including anterior naris; aorta; bone; nervous system; and retina. Used to study autoimmune disease. Orthologous to human CD200 (CD200 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 82.1), whole brain E14.5 (RPKM 45.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 29.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45202474..45229419, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45382111..45409060, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40916 Neighboring gene STARR-seq mESC enhancer starr_40917 Neighboring gene predicted gene, 30636 Neighboring gene STARR-positive B cell enhancer ABC_E7454 Neighboring gene predicted gene, 30760 Neighboring gene STARR-positive B cell enhancer mm9_chr16:45390029-45390330 Neighboring gene CD200 molecule like 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene ankyrin repeat domain 35 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD200 -dependent and -independent immune-modulatory functions of neural stem cells. Arad T, et al. Stem Cell Res, 2021 Oct. PMID 34634761
  2. Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke. Al Mamun A, et al. Stroke, 2021 Oct. PMID 34353112, Free PMC Article
  3. The CD200 Regulates Inflammation in Mice Independently of TNF-α Production. Tonecka K, et al. Int J Mol Sci, 2021 May 19. PMID 34069671, Free PMC Article
  4. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Kassiteridi C, et al. Circ Res, 2021 Jul 9. PMID 33975450, Free PMC Article
  5. CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages. Li D, et al. Int Immunopharmacol, 2020 Jan. PMID 31835080

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain endothelial CD200 signaling protects brain against ischemic damage.
    Title: Brain endothelial CD200 signaling protects brain against ischemic damage.
  2. Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
    Title: Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
  3. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
    Title: Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
  4. The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
    Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
  5. Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
    Title: Neuronal CD200 Signaling Is Protective in the Acute Phase of Ischemic Stroke.
  6. CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
    Title: CD200 -dependent and -independent immune-modulatory functions of neural stem cells.
  7. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
    Title: CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis.
  8. CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
    Title: CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
  9. The CD200 Regulates Inflammation in Mice Independently of TNF-alpha Production.
    Title: The CD200 Regulates Inflammation in Mice Independently of TNF-α Production.
  10. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
    Title: CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding involved in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in heterotypic cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macrophage migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuroinflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of arginase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
OX-2 membrane glycoprotein
Names
CD200 antigen
MRC OX-2 antigen
antigen identified by monoclonal antibody MRC OX-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358443.1 → NP_001345372.1  OX-2 membrane glycoprotein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC117686, AC117783
    Conserved Domains (2) summary
    pfam00047
    Location:69 → 155
    ig; Immunoglobulin domain
    cl11960
    Location:1 → 64
    Ig; Immunoglobulin domain

  2. NM_010818.3 → NP_034948.3  OX-2 membrane glycoprotein isoform 1 precursor

    See identical proteins and their annotated locations for NP_034948.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC054759, CN665640
    Consensus CDS
    CCDS49860.1
    UniProtKB/Swiss-Prot
    O54816, O54901, Q9JHD5
    UniProtKB/TrEMBL
    Q80VX2
    Related
    ENSMUSP00000130518.2, ENSMUST00000163230.8
    Conserved Domains (2) summary
    cd05846
    Location:44 → 140
    Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
    pfam00047
    Location:143 → 229
    ig; Immunoglobulin domain

RNA

  1. NR_189160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117686, AC117783

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45202474..45229419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316890.3 → XP_017172379.1  OX-2 membrane glycoprotein isoform X1

    Conserved Domains (1) summary
    pfam00047
    Location:47 → 133
    ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54901.1 GenPept UniProtKB/Swiss-Prot:O54901

Gene LinkOut

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