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Mov10 Mov10 RISC complex RNA helicase [ Mus musculus (house mouse) ]

Gene ID: 17454, updated on 3-Apr-2024

Summary

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Official Symbol
Mov10provided by MGI
Official Full Name
Mov10 RISC complex RNA helicaseprovided by MGI
Primary source
MGI:MGI:97054
See related
Ensembl:ENSMUSG00000002227 AllianceGenome:MGI:97054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mov-10
Summary
Predicted to enable 5'-3' RNA helicase activity and RNA binding activity. Involved in negative regulation of transposition, RNA-mediated and regulation of neuron projection arborization. Located in cytosol and nucleus. Is expressed in brain; gut; sensory organ; testis; and turbinate bone primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human MOV10 (Mov10 RISC complex RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 17.0), small intestine adult (RPKM 14.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.87 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104702144..104725935, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104794828..104818619, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response. Yang X, et al. PLoS Pathog, 2022 Feb. PMID 35157734, Free PMC Article
  2. Unwinding the roles of RNA helicase MOV10. Nawaz A, et al. Wiley Interdiscip Rev RNA, 2022 Mar. PMID 34327836, Free PMC Article
  3. Interaction of several related GC-box- and GT-box-binding proteins with the intronic enhancer is required for differential expression of the gb110 gene in embryonal carcinoma cells. Hamann L, et al. Mol Cell Biol, 1994 Sep. PMID 8065313, Free PMC Article
  4. Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the proviral genome. Schnieke A, et al. J Virol, 1983 Feb. PMID 6834466, Free PMC Article
  5. Infectivity and structure of molecular clones obtained from two genetically transmitted Moloney leukemia proviral genomes. Harbers K, et al. Nucleic Acids Res, 1982 Apr 24. PMID 6281733, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice.
    Title: The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice.
  2. Unwinding the roles of RNA helicase MOV10.
    Title: Unwinding the roles of RNA helicase MOV10.
  3. Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.
    Title: Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.
  4. FMRP and MOV10 regulate Dicer1 expression and dendrite development.
    Title: FMRP and MOV10 regulate Dicer1 expression and dendrite development.
  5. Mov10 is essential for normal neuronal development and brain function. Mov10 preferentially binds RNAs involved in actin binding, neuronal projection, and cytoskeleton. This is a completely new and critically important function for Mov10 in neuronal development.
    Title: Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated gene silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in retrotransposon silencing by mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative helicase MOV-10
Names
moloney leukemia virus 10 protein
NP_001156912.2
NP_001156913.1
NP_001397354.1
NP_001397355.1
NP_001397356.1
NP_001397357.1
NP_032645.2
XP_006501163.1
XP_006501164.1
XP_030108315.1
XP_036018811.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163440.2 → NP_001156912.2  putative helicase MOV-10 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171110
    Consensus CDS
    CCDS51033.1
    UniProtKB/Swiss-Prot
    P23249, Q9DC64
    Related
    ENSMUSP00000126897.2, ENSMUST00000166979.8

  2. NM_001163441.2 → NP_001156913.1  putative helicase MOV-10 isoform b

    See identical proteins and their annotated locations for NP_001156913.1

    Status: VALIDATED

    Source sequence(s)
    AC171110
    Consensus CDS
    CCDS38579.1
    UniProtKB/Swiss-Prot
    P23249, Q9DC64
    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Related
    ENSMUSP00000128246.2, ENSMUST00000168015.8
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  3. NM_001410425.1 → NP_001397354.1  putative helicase MOV-10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171110

  4. NM_001410426.1 → NP_001397355.1  putative helicase MOV-10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171110

  5. NM_001410427.1 → NP_001397356.1  putative helicase MOV-10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171110

  6. NM_001410428.1 → NP_001397357.1  putative helicase MOV-10 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171110

  7. NM_008619.3 → NP_032645.2  putative helicase MOV-10 isoform b

    See identical proteins and their annotated locations for NP_032645.2

    Status: VALIDATED

    Source sequence(s)
    AC171110
    Consensus CDS
    CCDS38579.1
    UniProtKB/Swiss-Prot
    P23249, Q9DC64
    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Related
    ENSMUSP00000002297.6, ENSMUST00000002297.12
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104702144..104725935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252455.1 → XP_030108315.1  putative helicase MOV-10 isoform X2

    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Conserved Domains (2) summary
    cd18808
    Location:679 → 884
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:443 → 678
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  2. XM_036162918.1 → XP_036018811.1  putative helicase MOV-10 isoform X2

    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Conserved Domains (2) summary
    cd18808
    Location:679 → 884
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:443 → 678
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  3. XM_006501100.1 → XP_006501163.1  putative helicase MOV-10 isoform X1

    See identical proteins and their annotated locations for XP_006501163.1

    UniProtKB/Swiss-Prot
    P23249, Q9DC64
    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

  4. XM_006501101.4 → XP_006501164.1  putative helicase MOV-10 isoform X1

    See identical proteins and their annotated locations for XP_006501164.1

    UniProtKB/Swiss-Prot
    P23249, Q9DC64
    UniProtKB/TrEMBL
    D3Z3E8, Q3TFC0, Q3UD86
    Conserved Domains (2) summary
    cd18808
    Location:735 → 940
    SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
    cd18038
    Location:499 → 734
    DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

RNA

  1. XR_375493.4 RNA Sequence

    Related
    ENSMUST00000106774.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23249.2 GenPept UniProtKB/Swiss-Prot:P23249

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