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Mnt max binding protein [ Mus musculus (house mouse) ]

Gene ID: 17428, updated on 25-Apr-2024

Summary

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Official Symbol
Mntprovided by MGI
Official Full Name
max binding proteinprovided by MGI
Primary source
MGI:MGI:109150
See related
Ensembl:ENSMUSG00000000282 AllianceGenome:MGI:109150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rox; bHLHd3
Summary
Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cell aging; negative regulation of apoptotic signaling pathway; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.8), adrenal adult (RPKM 10.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 45.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74721651..74736551)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74830806..74845725)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40198 Neighboring gene STARR-seq mESC enhancer starr_29970 Neighboring gene STARR-seq mESC enhancer starr_29971 Neighboring gene STARR-positive B cell enhancer ABC_E3000 Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene predicted gene, 57584 Neighboring gene STARR-positive B cell enhancer ABC_E8879 Neighboring gene STARR-positive B cell enhancer ABC_E11484 Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 20S rRNA accumulation Neighboring gene serine racemase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Toyo-oka K, et al. Cancer Res, 2006 Jun 1. PMID 16740691
  2. Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells. Dezfouli S, et al. Mol Cell Biol, 2006 Mar. PMID 16507988, Free PMC Article
  3. Evidence of mnt-myc antagonism revealed by mnt gene deletion. Hurlin PJ, et al. Cell Cycle, 2004 Feb. PMID 14712062
  4. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. Walker W, et al. J Cell Biol, 2005 May 9. PMID 15866886, Free PMC Article
  5. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Nilsson JA, et al. Mol Cell Biol, 2004 Feb. PMID 14749372, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
    Title: MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
  2. Although mnt heterozygosity clearly slowed lymphomagenesis in vavP-MYC10 and Emu-myc mice, the change(s) in cellular properties responsible for this effect remain to be identified.
    Title: Mnt modulates Myc-driven lymphomagenesis.
  3. results redefine the physiological relationship between Mnt and Myc and requirements for Myc-driven oncogenesis
    Title: A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
  4. Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
    Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
  5. The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.
    Title: Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
  6. Mnt represses Myc target genes and Myc functions as an oncogene by relieving Mnt-mediated repression
    Title: Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.
  7. There is a unique negative regulatory role for Mnt in governing key Myc functions associated with cell proliferation and tumorigenesis.
    Title: Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.
  8. Loss of protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects.
    Title: Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.
  9. Mnt may serve a general role as a Myc antagonist.[Review]
    Title: Evidence of mnt-myc antagonism revealed by mnt gene deletion.
  10. These results demonstrate that Mnt-Myc antagonism plays a fundamental role in regulating cell cycle entry and proliferation.
    Title: Mnt-Max to Myc-Max complex switching regulates cell cycle entry.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
max-binding protein MNT
Names
myc antagonist MNT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010813.3 → NP_034943.3  max-binding protein MNT

    See identical proteins and their annotated locations for NP_034943.3

    Status: VALIDATED

    Source sequence(s)
    AW491765, BC054534, CA327080
    Consensus CDS
    CCDS25037.1
    UniProtKB/Swiss-Prot
    O08789, P97349, Q6GTJ3
    UniProtKB/TrEMBL
    Q3UGG9
    Related
    ENSMUSP00000000291.3, ENSMUST00000000291.9
    Conserved Domains (1) summary
    cd11402
    Location:222 → 298
    bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74721651..74736551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532402.5 → XP_006532465.1  max-binding protein MNT isoform X1

    UniProtKB/TrEMBL
    Q3UGG9
    Conserved Domains (2) summary
    pfam10944
    Location:267 → 325
    DUF2630; Protein of unknown function (DUF2630)
    cd11402
    Location:221 → 284
    bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

  2. XM_006532403.4 → XP_006532466.1  max-binding protein MNT isoform X2

  3. XM_036156377.1 → XP_036012270.1  max-binding protein MNT isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08789.2 GenPept UniProtKB/Swiss-Prot:O08789

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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